Hydrodiuril® (hydrochlorthiazide) diuretic profile and use in contest prep

akn · Jun 19, 2014

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Hydrochlorothiazide is a diuretic from the thiazide family,

used medically for the treatment of edemas and hypertension.
This drug acts by reducing the reabsorption of electrolytes,
thereby increasing the excretion of sodium, potassium,
chloride, and consequently water. In comparison to other
diuretics, Hydrodiuril is stronger than the potassium sparing
agent Aldactone® (spironolactone), but weaker then the loop
agent Lasix (furosemide). While potassium excretion is much
less pronounced than that seen with Lasix, the use of a
potassium supplement (or a potassium rich diet) may still be
necessary with this product. This is usually dependent on the
dose and duration in which the drug is administered. Calcium
excretion may also be pronounced with thiazides, but again,
are weaker in this regard than Lasix.
The use of diuretics has been increasingly popular in a
number of athletic disciplines. For starters, these drugs are
very popular among bodybuilders who use them to shed
subcutaneous water before a competition. The ability to have
a winning physique often relies heavily on the definition that
can result from diuretic use. The highly defined, super hard
and shredded look common today in this sport is nearly
impossible to achieve without the use of these drugs. Many
athletes competing in sports with weight categories also
utilize diuretics. Wrestlers and boxers, for example, might
use diuretics to compete in a heavier weight class than would
be dictated by an earlier weigh-in measurement. Given that
the weight-in is usually done a day (or many hours) before a
competition, the athlete can reduce water weight with
diuretics, yet have enough time to restore fluids and
bodyweight before the event. The result can be a shift of one
or more weight categories, which can be a formidable
advantage in these types sports.
History:
Hydrochlorothiazide was developed during the 1950s. Given
the widespread nature of diseases associated with high blood
pressure and edema, the drug found a very large market, and
quickly achieved large-scale acceptance and distribution.
Hydrochlorothiazide became a fundamental form of therapy
in this area of medicine, where it remains widely available
today. Hydrochlorothiazide preparations are available in
virtually all developed nations, and appear in literally
hundreds of different brand name and generic products.
Single-ingredient preparations (where hydrochlorothiazide is
the only active drug) are far outnumbered by multi-ingredient
preparations, where the drug is often mixed with other

actives that focus on diuresis or blood pressure management.
How Supplied:
Hydrochlorothiazide is most commonly supplied in tablets of
25 mg and 50 mg.
Structural Characteristics:
Spironolactone is an aldosterone antagonist and diuretic. It
has the chemical designation 17-hydroxy-7alphamercapto- 3-
oxo-17alpha-pregn-4-ene-21-carboxylic acid y-lactone
acetate.
Warnings (Dehydration, Death):
The misuse of diuretic drugs for physique- or performanceenhancing
purposes is characterized as a high-risk practice.
Diuretics may produce a life-threatening level of dehydration
and electrolyte imbalance when administered without proper
medical supervision. Many deaths have been associated with
the misuse of these drugs.
Side Effects:
Hydrochlorthiazide use may be associated with electrolyte
imbalance. This may include potassium and sodium
deficiency, as well as hypochloremic alkalosis (an increase
in blood bicarbonate due to significant chloride loss). Signs
of electrolyte imbalance include dry mouth, thirst, weakness,
lethargy, drowsiness, restlessness, muscle pain, muscle
cramping, seizures, reduced urine volume, low blood
pressure, and gastrointestinal disturbances. Other side effects
may include reduced appetite, nausea, vomiting, constipation,
diarrhea, inflammation of salivary gland(s), headache,
dizziness, sensitivity to light, low blood pressure upon
standing, skin irritation, impotence, visual disturbances,
jaundice, pancreatitis, and inflammation of the lung(s).
Additionally, some rare side effects characterized as
hypersensitivity reactions have been reported including skin
rash, fever, shock, pulmonary edema, and respiratory
distress.
Administration:
When used medically to treat hypertension, the usual initial
dose in adults is 25 mg daily given as a single dose. The
dose may be increased to 50 mg daily, often in two doses of
25 mg. Note that daily doses above 50 mg are often
associated with marked reductions in serum potassium.
Athletes and bodybuilders typically use this drug (off-label)
for very brief periods (several days) of water adjustment. A
common practice is to administer this drug once per day,
after the morning meal. The athlete will monitor the level of
water lost throughout the day, and adjust the dosage for the
following day if necessary. The usual starting dosage is one
50 mg tablet. The user will adjust the effect by adding a 25
mg or 50 mg tablet each subsequent day. This practice is only
followed for three or four days, until an optimal dosage is
calculated. The total daily dosage will rarely exceed 100-
200 mg (doses above 100 mg per day in a clinical setting are
not commonly recommended).
If the application of hydrochlorothiazide is not producing the
desired effect, many bodybuilders/athletes will choose to
add another diuretic (mild) before moving to the stronger
loop agents. A combination of a potassium sparing diuretic
like Aldactone® (spironolactone) and Hydrodiuril is
regarded as particularly useful by many, and is believed to
slightly balance out the calcium and potassium loss
associated with the use of hydrochlorothiazide. The dosage
of each agent would be reduced considerably, usually
starting with a 25 mg/25 mg application and working
upwards.
It is important to note that the overuse of diuretics, aside
from being potentially very dangerous, may result in too
much water loss. This can lead to flat, “deflated” looking
muscles. A higher diuretic dosage, likewise, does not always
equate to increased definition and muscularity. It is usually
regarded as good advice by those in the athletic community
to become familiar with the practice of using diuretics before
using them during competition time. Otherwise, the user may
be left to make frantic dosage adjustments at the last minute,
which can be a dangerous and ineffective practice.
Availability:
Hydrochlorothiazide is widely manufactured in both single
ingredient and multi-ingredient drug preparations. Low cost
and wide scale availability make this a poor financial target
for counterfeiting.

By WL

Presser · Jan 11, 2016

<h1>Hydrochlorothiazide</h1> i do not know anyone who has used this for pre contest prep recently. How readily available is this diuretic?

Hydrodiuril® (hydrochlorthiazide) diuretic profile and use in contest prep

akn

Musclechemistry Member

Presser

Admin

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