Provigil® (modafinil) Endurance/Erythropoietic Drug profile and performance enhancing

akn · Jun 20, 2014

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Modafinil, known chemically as
benzhydrylsulphinylacetamide, is a central stimulant
(psychostimulant). It is FDA approved for the treatment of
narcolepsy (a disorder characterized by sudden and
uncontrollable attacks of deep sleep, mental fatigue, or
excessive sleepiness), sleep apnea, and SWSD (Shift Work
Sleep Disorder). It is being investigated for a number of
other uses, including the treatment of Alzheimer’s disease,
depression, and attention deficit disorder. Modafinil belongs
to a group of drugs known as Eugeroics (“good arousal"),
designed to promote a mental state of vigilance and alertness.
One of its known mechanisms is to work as an alpha-1
adrenoceptor agonist, exerting its mood and energy enhancing
effects through the increased release of dopamine in the
CNS. It also results in alterations in local GABA and
glutamate levels.
The use of modafinil as a stimulant has been shown in studies
to have many advantages over amphetamines. To begin with,
it is believed to have a much lower potential for abuse due to
the fact that it produces a lower sense of euphoria. It also
displays lower peripheral CNS stimulation (less side
effects), has minimal effects on blood pressure, produces no
interruptions in normal sleeping patterns (no hangover or
needing “catch-up” sleep), and has an overall greater safety
profile according to clinical trials. This drug is of interest
even to the U.S. military, which is looking at it as an energy
enhancer for pilots and combat soldiers that need to operate
for long periods of time without sleep.This is not as unusual
as it may seem at first, as military combat pilots and soldiers
have used Dexedrine (an amphetamine) extensively in the
past when sleep was inconvenient. Soldiers on modafinil
often report that they maintain excellent cognitive functioning
for up to 40 hours without sleep, and have fewer side effects
than Dexedrine. Modafinil has been tested in recent combat
situations such as in Afghanistan and Iraq, and seems poised
for official acceptance as a battlefield drug.
Recently, modafinil has become a popular drug among
competitive athletes. They use it not simply to “stay awake”
but as a performance enhancing agent with both stimulant and
endurance-increasing properties. This type of use probably
comes as a surprise to those who developed this drug, as
early reports suggested that this was a “mild” alertness drug,
without strong stimulant properties that would improve
athletic performance. Recent studies contradict this
determination. A study conducted in Canada shows a very
strong athletic benefit inherent in modafinil.687 During this
double-blind investigation, a dose of 4 mg per kg of
bodyweight (this equates to 200 mg for a 220lb man) of
modafinil, or placebo, was given to a group of 15 male
volunteers. Three hours after ingestion, aerobic exercise was
conducted on a cycle ergometer at 85% V02max (maximum
aerobic power), and the amount of time until exhaustion was
determined. While taking modafinil, the men were able to
exercise for significantly longer periods of time (~30%), and
had greater oxygen intake at exertion. They also reported
lower subjective ratings of perceived exertion (RPE), which
suggests that the increased performance was in part due to a
significantly less pronounced sensation of fatigue during
exercise.
History:
Modafinil was developed by Lafon Laboratories in France. It
was approved for sale in the United States by the FDA in
1998, where it was introduced under the Provigil® brand
name. Modafinil is also found internationally under this and
several additional trade names including Modiodal®,
Vigil®, Alertec®, and Modasomil®. Although the drug
appears to have a favorable safety record and profile, it was
quickly considered a drug of potential abuse in the U.S. It is
presently classified as a schedule IV controlled substance,
which places modafinil in the same category as Valium and
Xanax. This is intended to limit its diversion for nonmedical
purposes by placing considerable legal penalties on its
possession and importation. The medical applications for the
drug are fairly broad, however, including SWSD, which
refers to sleep disturbances caused by changing- or late-shift
work. Prescriptions for the drug are, likewise, commonly
granted by physicians in general medical practice.
Modafinil quietly became popular among competitive
athletes between 2000 and 2004, before the athletic bodies
were aware of the drug. Its use as a performance-enhancing
agent was revealed to the public during the designer steroid
(BALCO) doping scandal of 2004, however, when it was
disclosed that many of the same athletes who tested positive
for THG also used modafinil.The IOC quickly banned its
use, and with the help of a number of researchers a
methodology for detecting this chemical in the urine was
developed. This test is now implemented as part of the
standard Olympic level drug screening process. Most of the
other international athletic bodies have followed the IOC’s
lead in banning and testing for modafinil. The drug has since
lost all appeal as an “invisible” performance-enhancing
agent, although is still being used by many athletes that are
not subject to random urine testing.
How Supplied:
Modafinil is most commonly supplied in tablets of 100 mg
and 200 mg each.
Structural Characteristics:
Modafinil is a central nervous system stimulant related to
adrafinil. It has the chemical designation 2-
[(diphenylmethyl)sulfinyl]acetamide.
Side Effects:
Side effects associated with modafinil are commonly the
result of its central nervous system stimulating activities, and
may include nervousness, insomnia, shakiness, euphoria,
personality changes, and excitation. The drug may also
produce gastrointestinal disturbances such as nausea,
vomiting, abdominal pain, dry mouth, anorexia, and
headache. Hypertension, heart palpitations, or abnormal
heart rate may also be noticed. In rare instances allergic rash,
increases in alkaline phosphatase, or impaired voluntary
movement have been reported.
Administration:
When used clinically to treat excessive daytime sleepiness
associated with narcolepsy or obstructive sleep apnea, the
recommended dose is typically 200 to 400 mg per day. This
may be given in a single morning application, or in two
divided doses (morning and at midday). When used to
enhance physical performance, the typical effective dose is
in the range of 100-400 mg. This is often given at least 2-3
hours prior to athletic competition. Note that side effects can
be dose dependant. It is often advised to start using modafinil
on the low end of the effective dosage range, and increase by
50-100 mg per application until an optimal level is
determined.
The arenas in which this drug is applied are vast, and
essentially include any sport focused on aerobic activity or
endurance. It may also work well with those athletes focused
on short repeat bursts of strength or speed (anaerobic
activities), such as shot-putting, pole-vaulting, or longjumping.
Modafinil is not a popular drug among
bodybuilders, as it holds little direct value for building
muscle or reducing body fat levels. Some, however, do find
it to be an effective pre-workout stimulant, especially during
periods when fatigue or loss of physical drive may be
noticed subsequent to a busy work or personal schedule.
Availability:
Modafinil is presently available in more than two dozen
countries. The drug is not highly diverted for black market
sale, however, and is not a lucrative target for drug
counterfeiting operations.

By WL

echo419 · Jun 20, 2014

got to get my hands on some of this. I work pretty much everyday and super late twice a week. as a result I'm sleepy or at least dragging ass most of the afternoon. so when it comes time to train it's all I can do to get my ass up and to the gym.

focused1974 · Jun 20, 2014

It is great.

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IronJulius · Jun 20, 2014

i was prescribe it but i felt weird for a week so stopped taking it

IronJulius · Jun 20, 2014

I will say most people love it and its a life saver thats just not my experience

- - - Updated - - -

I posted on here some of my experience while taking it

CR6 · Jun 20, 2014

I posted a comment about Provigil & Nuvigil (modafinil) a few months back in another thread and I can assure you, this is the shit!

I've been on it for almost a year now and haven't experienced any negative side effects. It did make my mouth dry the first few times I took it, but that goes away over time. And it will keep your ass awake at night (at least for me) if you take it after 2-3pm (depending on what time your normally go to bed) It's expensive as shit if your insurance won't cover it. Most ins companies will make you take a sleep study before they will cover it. I usually purchase 3 each at a time as my pharmacy charges 49 bucks for 3 pills, but at the same time I only take it "as needed" and usually a half a pill works perfectly. (although a whole is optimal)
I've taken Ritalin and similar meds in the past and never cared for how that stuff made me feel all jittery and shit. Modafinil simply keeps you sharp & alert and is unlike any stimulant you've ever tried. No come down feeling and non addictive, it just works as IronJ stated. :thumbup:
You shouldn't have to see a sleep Dr to get a script, just ask your primary care Dr. (now getting your ins to cover it is a different story) lol

keith1569 · Jun 21, 2014

I love the stuff I just can't get a script for it. Even when I had sleep work disorder due to my work schedule

focused1974 · Jun 21, 2014

What about buying online?

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Presser · Jun 21, 2014

hmm i wonder if sex is good on it? i use to love sex all amped the fuck up, but that was years ago, before the new borns , long before them actually , but yeah still curious how sex it on this stuff

goodness · Jun 21, 2014

Shit I remember being amped up back in the day. Never could get it up to have sex lmao.

Presser · Jun 21, 2014

goodness said:
Shit I remember being amped up back in the day. Never could get it up to have sex lmao.

lol, yeah sometimes that was an issue, but most of the time it would make me rock mother fucking hard! lol

focused1974 · Jun 21, 2014

LOL!

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CR6 · Jun 21, 2014

Presser said:
hmm i wonder if sex is good on it? i use to love sex all amped the fuck up, but that was years ago, before the new borns , long before them actually , but yeah still curious how sex it on this stuff

It doesn't really affect sex one way or the other. I've never had a problem in the sack while on it, but at the same time it's not going to make you last longer or anything like that. Sorry Presser! LOL

focused1974 said:
What about buying online?
Sent from my iPhone using Tapatalk

You can find a few places online that sell it, although I don't know how reliable they are.

focused1974 · Jun 21, 2014

Provigil :: Sleep disorders - buy Provigil online, Provigil prescription, full description, side effects
Thoughts on this site? They have a guarantee.,,

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Presser · Oct 10, 2015

I think I am gonna ask my doctor for this stuff!

Mountain_Man · Oct 10, 2015

Had a script for it in 99 did not work well for me I still fell asleep at 600 mg

CR6 · Oct 29, 2015

You must have had some bad shit. I can take a half of a 200mg pill and it does the job. A full pill works perfectly. No jitters, no crash, no bad side effects or dependence issues.
Just picked up my refill last night.

Presser · Aug 30, 2016

I see your script is from Mylan, no quality control issues, like some are stronger than others? I found some gereic brands like that before, specifically TEVA

Presser · Aug 31, 2016

took 200mg Modafinil this morning, worked great! Only my 2nd day though, yesterday I did half a tab (100mg) , in anycase, i found myself lost in work this morning, very clear! I also took my usual ECA stack this morning before the Modafinil,

Provigil® (modafinil) Endurance/Erythropoietic Drug profile and performance enhancing

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