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View Full Version : Synovex® (testosterone propionate & estradiol) steroid blend implant profile



akn
07-10-2014, 09:28 PM
<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves/> <w:TrackFormatting/> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF/> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> <w:SplitPgBreakAndParaMark/> <w:DontVertAlignCellWithSp/> <w:DontBreakConstrainedForcedTables/> <w:DontVertAlignInTxbx/> <w:Word11KerningPairs/> <w:CachedColBalance/> <w:UseFELayout/> </w:Compatibility> <w:DoNotOptimizeForBrowser/> <m:mathPr> <m:mathFont m:val="Cambria Math"/> <m:brkBin m:val="before"/> <m:brkBinSub m:val="&#45;-"/> <m:smallFrac m:val="off"/> <m:dispDef/> <m:lMargin m:val="0"/> <m:rMargin m:val="0"/> <m:defJc m:val="centerGroup"/> <m:wrapIndent m:val="1440"/> <m:intLim m:val="subSup"/> <m:naryLim m:val="undOvr"/> </m:mathPr></w:WordDocument> </xml><![endif]--> Description
Synovex is a blended-ingredient steroid implant preparation,
which is available only as a veterinary item for use in
cattle.The implant comes in the form of small pellets, which
are pushed into the ear of an animal with a very large implant
gun. Once implanted, the pellets slowly dissolve, providing
an extended release of steroids for many weeks. The
hormone content of Synovex is mixed, with each pellet
containing 25 mg testosterone propionate and 2.5 mg
estradiol benzoate. This 10:1 ratio has been demonstrated to
provide an added anabolic/weight gaining effect in feed
animals, improving the value of the livestock. Given its
estrogen content, Synovex is clearly not an ideal steroid for
humans. Most athletes have only become attracted to this
product out of sheer desperation for legitimate anabolics, as
cattle implants like this are not regulated as controlled
substances in the U.S. to spite their steroid content.
Otherwise, a pure testosterone propionate product would be
much more appropriate.
History:
Testosterone propionate plus estrogen implant pellets were
first approved by the U.S. Food and Drug administration for
use in heifers in 1958.591 Diethylstilbestrol, a potent estrogen
often used to increase animal carcass weight, had been
approved four years earlier for use in cattle, however, and
would remain the leading product for many years. Syntex
introduced their version of testosterone/estrogen pellets
(Synovex) during the early 1970’s, as part of the company’s
new Animal Health division. This was during a time a time
when diethylstilbestrol was getting a great deal of negative
publicity. Synovex became a huge seller when the FDA
banned the use of diethylstilbestrol in 1973, the product
quickly capturing more than 50% of the market for growthpromoting
implants. The popularity of Synovex soon caught
the attention of other companies, a number of which soon
started making their own blended testosterone/estrogen
implants. Popular brand names in the U.S. have included FTO
(Upjohn), Heifer-oid (Boehringer), and Implus (Upjohn).
Synovex and other testosterone/estrogen pellets remain
widely available in the U.S. and abroad today, although are
not highly popular with athletes given their estrogen content.
How Supplied:
Synovex contains 25 mg of testosterone propionate and 2.5
mg of estradiol benzoate in a small sterile implantation
pellet. The number of pellets in each cartridge dose will vary
depending on the intended target animal. Implants denoted
“H” for heifer will carry the most; in the case of U.S.
Synovex-H it is 80 pellets (10 doses consisting each of 8
pellets). We will see a slightly lower pellet count in the “S”
implants (steer) and “C” (calf ) cartridges.
Structural Characteristics:
Testosterone propionate is a modified form of testosterone,
where a carboxylic acid ester (propionic acid) has been
attached to the 17-beta hydroxyl group to slow the release of
testosterone from the area of implantation. This preparation
also contains an ester (benzoic acid) of estradiol.
Side Effects (Estrogenic):
Testosterone is readily aromatized in the body to estradiol
(estrogen). Additionally, this preparation contains an active
estrogen. Elevated estrogen levels can cause side effects
such as increased water retention, body fat gain, and
gynecomastia. This steroid preparation is considered to be
highly estrogenic. An anti-estrogen such as clomiphene
citrate or tamoxifen citrate may be necessary to prevent
estrogenic side effects. One may alternately use an aromatase
inhibitor like Arimidex® (anastrozole), although it will not
have an affect on the additional estrogen present in the
preparation. Since water retention and loss of muscle
definition are common with highly estrogenic steroid
products, this drug is usually considered a poor choice for
dieting or cutting phases of training. It would only be
appropriate during bulking phases, where the added water
retention will support raw strength and muscle size, and help
foster a stronger anabolic environment.
Side Effects (Androgenic):
Testosterone is the primary male androgen, responsible for
maintaining secondary male sexual characteristics. Elevated
levels of testosterone are likely to produce androgenic side
effects including oily skin, acne, and body/facial hair growth.
Men with a genetic predisposition for hair loss (androgenetic
alopecia) may notice accelerated male pattern balding.
Those concerned about hair loss may find a more
comfortable option in nandrolone decanoate, which is a
comparably less androgenic steroid. Women are warned of
the potential virilizing effects of anabolic/androgenic
steroids, especially with a strong androgen such as
testosterone. These may include deepening of the voice,
menstrual irregularities, changes in skin texture, facial hair
growth, and clitoral enlargement.
Side Effects (Hepatotoxicity):
Testosterone and estrogen do not have hepatotoxic effects;
liver toxicity is unlikely.
Side Effects (Cardiovascular):
Anabolic/androgenic steroids can have deleterious effects on
serum cholesterol. This includes a tendency to reduce HDL
(good) cholesterol values and increase LDL (bad)
cholesterol values, which may shift the HDL to LDL balance
in a direction that favors greater risk of arteriosclerosis. The
relative impact of an anabolic/androgenic steroid on serum
lipids is dependant on the dose, route of administration (oral
vs. injectable), type of steroid (aromatizable or nonaromatizable),
and level of resistance to hepatic metabolism.
Testosterone tends to have a much less dramatic impact on
cardiovascular risk factors than synthetic steroids. This is
due in part to its openness to metabolism by the liver, which
allows it to have less effect on the hepatic management of
cholesterol. The aromatization of testosterone to estradiol
also helps to mitigate the negative effects of androgens on
serum lipids. The added estrogen in this product may further
help to offset some of the androgenic effect on lipid values,
and the preparation may, therefore, have a weaker impact on
cholesterol than a comparably dosed straight testosterone
product. Anabolic/androgenic steroids may also adversely
affect blood pressure and triglycerides, reduce endothelial
relaxation, and support left ventricular hypertrophy, all
potentially increasing the risk of cardiovascular disease and
myocardial infarction.
Side Effects (Testosterone Suppression):
All anabolic/androgenic steroids when taken in doses
sufficient to promote muscle gain are expected to suppress
endogenous testosterone production. Testosterone is the
primary male androgen, and offers strong negative feedback
on endogenous testosterone production. The added estrogen
will also provide negative-feedback suppression. This
preparation should have a strong effect on the hypothalamic
regulation of natural steroid hormones. Without the
intervention of testosterone stimulating substances,
testosterone levels should return to normal within 1-4 months
of drug secession. Note that prolonged hypogonadotrophic
hypogonadism can develop secondary to steroid abuse,
necessitating medical intervention.
To help reduce cardiovascular strain it is advised to
maintain an active cardiovascular exercise program and
minimize the intake of saturated fats, cholesterol, and simple
carbohydrates at all times during active AAS administration.
Supplementing with fish oils (4 grams per day) and a natural
cholesterol/antioxidant formula such as Lipid Stabil or a
product with comparable ingredients is also recommended.
Administration (General):
Synovex implant pellets were not designed for human
consumption. To make use of these pellets, they must be
converted into another (more suitable) delivery form. To do
this, an athlete will typically grind them up and rub them on
the skin in a 50/50 mixture of DMSO and water to facilitate
transdermal delivery. Alternately, one may mix up a
homebrew injection with the pellets. This is done by grinding
them into a fine powder and introducing the powder into
filtered oil or an oil-based steroid. One should remember
that the practice of preparing Synovex for injection is not
going to be sterile, and as such could be potentially
dangerous. Note that some methods have additionally been
published for removing the estrogen from the pellets, to make
the drug more comfortable to use. They generally involve the
use of highly flammable materials, take a number of different
steps to complete, and leave some estrogen when the process
is over, however, usually making the process more trouble
than it is worth.
Administration (Men):
Synovex is not approved for use in humans. Prescribing
guidelines are unavailable. When used for physique- or
performance-enhancing purposes (very rarely), the dose is
calculated based on the route of administration. When given
by transdermal delivery, a bioavailability rate of no more
than 10% is assumed. A daily dosage of 4 pellets (100 mg)
would, therefore, provide the equivalent of 70 mg per week
of testosterone propionate (as given by injection). When
given by injection a dose of 100 mg every second or third
day is most common. The drug is generally taken for no more
than 8 weeks, and is used almost exclusively during bulking
phases of training. Those who have experimented with this
product have been generally disappointed with the results, as
the added estrogen has often resulted in rapid gynecomastia,
noticeable body fat accumulation, and severe water retention.
In many cases the water retained has caused an unsightly
bloated look (extreme loss of definition).
Administration (Women):
Synovex is not approved for use in humans. Prescribing
guidelines are unavailable. Synovex is not recommended for
women for physique- or performance-enhancing purposes
due to its strong androgenic nature and tendency to produce
virilizing side effects.
Availability:
Synovex is rarely found on the black market, given that the
product is in poor demand and generally can be obtained
through legitimate Agricultural or Veterinary supply stores.
No counterfeits have ever been known to exist.

By WL
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