akn
Musclechemistry Member
<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves/> <w:TrackFormatting/> <wunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <woNotPromoteQF/> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <wontGrowAutofit/> <w:SplitPgBreakAndParaMark/> <wontVertAlignCellWithSp/> <wontBreakConstrainedForcedTables/> <wontVertAlignInTxbx/> <w:Word11KerningPairs/> <w:CachedColBalance/> <w:UseFELayout/> </w:Compatibility> <woNotOptimizeForBrowser/> <m:mathPr> <m:mathFont m:val="Cambria Math"/> <m:brkBin m:val="before"/> <m:brkBinSub m:val="--"/> <m:smallFrac m:val="off"/> <m:dispDef/> <m:lMargin m:val="0"/> <m:rMargin m:val="0"/> <m:defJc m:val="centerGroup"/> <m:wrapIndent m:val="1440"/> <m:intLim m:val="subSup"/> <m:naryLim m:val="undOvr"/> </m:mathPr></w:WordDocument> </xml><![endif]--> [FONT="] Description[/FONT]
[FONT="]Synovex is a blended-ingredient steroid implant preparation,[/FONT]
[FONT="]which is available only as a veterinary item for use in[/FONT]
[FONT="]cattle.The implant comes in the form of small pellets, which[/FONT]
[FONT="]are pushed into the ear of an animal with a very large implant[/FONT]
[FONT="]gun. Once implanted, the pellets slowly dissolve, providing[/FONT]
[FONT="]an extended release of steroids for many weeks. The[/FONT]
[FONT="]hormone content of Synovex is mixed, with each pellet[/FONT]
[FONT="]containing 25 mg testosterone propionate and 2.5 mg[/FONT]
[FONT="]estradiol benzoate. This 10:1 ratio has been demonstrated to[/FONT]
[FONT="]provide an added anabolic/weight gaining effect in feed[/FONT]
[FONT="]animals, improving the value of the livestock. Given its[/FONT]
[FONT="]estrogen content, Synovex is clearly not an ideal steroid for[/FONT]
[FONT="]humans. Most athletes have only become attracted to this[/FONT]
[FONT="]product out of sheer desperation for legitimate anabolics, as[/FONT]
[FONT="]cattle implants like this are not regulated as controlled[/FONT]
[FONT="]substances in the U.S. to spite their steroid content.[/FONT]
[FONT="]Otherwise, a pure testosterone propionate product would be[/FONT]
[FONT="]much more appropriate.[/FONT]
[FONT="]History:[/FONT]
[FONT="]Testosterone propionate plus estrogen implant pellets were[/FONT]
[FONT="]first approved by the U.S. Food and Drug administration for[/FONT]
[FONT="]use in heifers in 1958.591 Diethylstilbestrol, a potent estrogen[/FONT]
[FONT="]often used to increase animal carcass weight, had been[/FONT]
[FONT="]approved four years earlier for use in cattle, however, and[/FONT]
[FONT="]would remain the leading product for many years. Syntex[/FONT]
[FONT="]introduced their version of testosterone/estrogen pellets[/FONT]
[FONT="](Synovex) during the early 1970’s, as part of the company’s[/FONT]
[FONT="]new Animal Health division. This was during a time a time[/FONT]
[FONT="]when diethylstilbestrol was getting a great deal of negative[/FONT]
[FONT="]publicity. Synovex became a huge seller when the FDA[/FONT]
[FONT="]banned the use of diethylstilbestrol in 1973, the product[/FONT]
[FONT="]quickly capturing more than 50% of the market for growthpromoting[/FONT]
[FONT="]implants. The popularity of Synovex soon caught[/FONT]
[FONT="]the attention of other companies, a number of which soon[/FONT]
[FONT="]started making their own blended testosterone/estrogen[/FONT]
[FONT="]implants. Popular brand names in the U.S. have included FTO[/FONT]
[FONT="](Upjohn), Heifer-oid (Boehringer), and Implus (Upjohn).[/FONT]
[FONT="]Synovex and other testosterone/estrogen pellets remain[/FONT]
[FONT="]widely available in the U.S. and abroad today, although are[/FONT]
[FONT="]not highly popular with athletes given their estrogen content.[/FONT]
[FONT="]How Supplied:[/FONT]
[FONT="]Synovex contains 25 mg of testosterone propionate and 2.5[/FONT]
[FONT="]mg of estradiol benzoate in a small sterile implantation[/FONT]
[FONT="]pellet. The number of pellets in each cartridge dose will vary[/FONT]
[FONT="]depending on the intended target animal. Implants denoted[/FONT]
[FONT="]“H” for heifer will carry the most; in the case of U.S.[/FONT]
[FONT="]Synovex-H it is 80 pellets (10 doses consisting each of 8[/FONT]
[FONT="]pellets). We will see a slightly lower pellet count in the “S”[/FONT]
[FONT="]implants (steer) and “C” (calf ) cartridges.[/FONT]
[FONT="]Structural Characteristics:[/FONT]
[FONT="]Testosterone propionate is a modified form of testosterone,[/FONT]
[FONT="]where a carboxylic acid ester (propionic acid) has been[/FONT]
[FONT="]attached to the 17-beta hydroxyl group to slow the release of[/FONT]
[FONT="]testosterone from the area of implantation. This preparation[/FONT]
[FONT="]also contains an ester (benzoic acid) of estradiol.[/FONT]
[FONT="]Side Effects (Estrogenic):[/FONT]
[FONT="]Testosterone is readily aromatized in the body to estradiol[/FONT]
[FONT="](estrogen). Additionally, this preparation contains an active[/FONT]
[FONT="]estrogen. Elevated estrogen levels can cause side effects[/FONT]
[FONT="]such as increased water retention, body fat gain, and[/FONT]
[FONT="]gynecomastia. This steroid preparation is considered to be[/FONT]
[FONT="]highly estrogenic. An anti-estrogen such as clomiphene[/FONT]
[FONT="]citrate or tamoxifen citrate may be necessary to prevent[/FONT]
[FONT="]estrogenic side effects. One may alternately use an aromatase[/FONT]
[FONT="]inhibitor like Arimidex® (anastrozole), although it will not[/FONT]
[FONT="]have an affect on the additional estrogen present in the[/FONT]
[FONT="]preparation. Since water retention and loss of muscle[/FONT]
[FONT="]definition are common with highly estrogenic steroid[/FONT]
[FONT="]products, this drug is usually considered a poor choice for[/FONT]
[FONT="]dieting or cutting phases of training. It would only be[/FONT]
[FONT="]appropriate during bulking phases, where the added water[/FONT]
[FONT="]retention will support raw strength and muscle size, and help[/FONT]
[FONT="]foster a stronger anabolic environment.[/FONT]
[FONT="]Side Effects (Androgenic):[/FONT]
[FONT="]Testosterone is the primary male androgen, responsible for[/FONT]
[FONT="]maintaining secondary male sexual characteristics. Elevated[/FONT]
[FONT="]levels of testosterone are likely to produce androgenic side[/FONT]
[FONT="]effects including oily skin, acne, and body/facial hair growth.[/FONT]
[FONT="]Men with a genetic predisposition for hair loss (androgenetic[/FONT]
[FONT="]alopecia) may notice accelerated male pattern balding.[/FONT]
[FONT="]Those concerned about hair loss may find a more[/FONT]
[FONT="]comfortable option in nandrolone decanoate, which is a[/FONT]
[FONT="]comparably less androgenic steroid. Women are warned of[/FONT]
[FONT="]the potential virilizing effects of anabolic/androgenic[/FONT]
[FONT="]steroids, especially with a strong androgen such as[/FONT]
[FONT="]testosterone. These may include deepening of the voice,[/FONT]
[FONT="]menstrual irregularities, changes in skin texture, facial hair[/FONT]
[FONT="]growth, and clitoral enlargement.[/FONT]
[FONT="]Side Effects (Hepatotoxicity):[/FONT]
[FONT="]Testosterone and estrogen do not have hepatotoxic effects;[/FONT]
[FONT="]liver toxicity is unlikely.[/FONT]
[FONT="]Side Effects (Cardiovascular):[/FONT]
[FONT="]Anabolic/androgenic steroids can have deleterious effects on[/FONT]
[FONT="]serum cholesterol. This includes a tendency to reduce HDL[/FONT]
[FONT="](good) cholesterol values and increase LDL (bad)[/FONT]
[FONT="]cholesterol values, which may shift the HDL to LDL balance[/FONT]
[FONT="]in a direction that favors greater risk of arteriosclerosis. The[/FONT]
[FONT="]relative impact of an anabolic/androgenic steroid on serum[/FONT]
[FONT="]lipids is dependant on the dose, route of administration (oral[/FONT]
[FONT="]vs. injectable), type of steroid (aromatizable or nonaromatizable),[/FONT]
[FONT="]and level of resistance to hepatic metabolism.[/FONT]
[FONT="]Testosterone tends to have a much less dramatic impact on[/FONT]
[FONT="]cardiovascular risk factors than synthetic steroids. This is[/FONT]
[FONT="]due in part to its openness to metabolism by the liver, which[/FONT]
[FONT="]allows it to have less effect on the hepatic management of[/FONT]
[FONT="]cholesterol. The aromatization of testosterone to estradiol[/FONT]
[FONT="]also helps to mitigate the negative effects of androgens on[/FONT]
[FONT="]serum lipids. The added estrogen in this product may further[/FONT]
[FONT="]help to offset some of the androgenic effect on lipid values,[/FONT]
[FONT="]and the preparation may, therefore, have a weaker impact on[/FONT]
[FONT="]cholesterol than a comparably dosed straight testosterone[/FONT]
[FONT="]product. Anabolic/androgenic steroids may also adversely[/FONT]
[FONT="]affect blood pressure and triglycerides, reduce endothelial[/FONT]
[FONT="]relaxation, and support left ventricular hypertrophy, all[/FONT]
[FONT="]potentially increasing the risk of cardiovascular disease and[/FONT]
[FONT="]myocardial infarction.[/FONT]
[FONT="]Side Effects (Testosterone Suppression):[/FONT]
[FONT="]All anabolic/androgenic steroids when taken in doses[/FONT]
[FONT="]sufficient to promote muscle gain are expected to suppress[/FONT]
[FONT="]endogenous testosterone production. Testosterone is the[/FONT]
[FONT="]primary male androgen, and offers strong negative feedback[/FONT]
[FONT="]on endogenous testosterone production. The added estrogen[/FONT]
[FONT="]will also provide negative-feedback suppression. This[/FONT]
[FONT="]preparation should have a strong effect on the hypothalamic[/FONT]
[FONT="]regulation of natural steroid hormones. Without the[/FONT]
[FONT="]intervention of testosterone stimulating substances,[/FONT]
[FONT="]testosterone levels should return to normal within 1-4 months[/FONT]
[FONT="]of drug secession. Note that prolonged hypogonadotrophic[/FONT]
[FONT="]hypogonadism can develop secondary to steroid abuse,[/FONT]
[FONT="]necessitating medical intervention.[/FONT]
[FONT="]To help reduce cardiovascular strain it is advised to[/FONT]
[FONT="]maintain an active cardiovascular exercise program and[/FONT]
[FONT="]minimize the intake of saturated fats, cholesterol, and simple[/FONT]
[FONT="]carbohydrates at all times during active AAS administration.[/FONT]
[FONT="]Supplementing with fish oils (4 grams per day) and a natural[/FONT]
[FONT="]cholesterol/antioxidant formula such as Lipid Stabil or a[/FONT]
[FONT="]product with comparable ingredients is also recommended.[/FONT]
[FONT="]Administration (General):[/FONT]
[FONT="]Synovex implant pellets were not designed for human[/FONT]
[FONT="]consumption. To make use of these pellets, they must be[/FONT]
[FONT="]converted into another (more suitable) delivery form. To do[/FONT]
[FONT="]this, an athlete will typically grind them up and rub them on[/FONT]
[FONT="]the skin in a 50/50 mixture of DMSO and water to facilitate[/FONT]
[FONT="]transdermal delivery. Alternately, one may mix up a[/FONT]
[FONT="]homebrew injection with the pellets. This is done by grinding[/FONT]
[FONT="]them into a fine powder and introducing the powder into[/FONT]
[FONT="]filtered oil or an oil-based steroid. One should remember[/FONT]
[FONT="]that the practice of preparing Synovex for injection is not[/FONT]
[FONT="]going to be sterile, and as such could be potentially[/FONT]
[FONT="]dangerous. Note that some methods have additionally been[/FONT]
[FONT="]published for removing the estrogen from the pellets, to make[/FONT]
[FONT="]the drug more comfortable to use. They generally involve the[/FONT]
[FONT="]use of highly flammable materials, take a number of different[/FONT]
[FONT="]steps to complete, and leave some estrogen when the process[/FONT]
[FONT="]is over, however, usually making the process more trouble[/FONT]
[FONT="]than it is worth.[/FONT]
[FONT="]Administration (Men):[/FONT]
[FONT="]Synovex is not approved for use in humans. Prescribing[/FONT]
[FONT="]guidelines are unavailable. When used for physique- or[/FONT]
[FONT="]performance-enhancing purposes (very rarely), the dose is[/FONT]
[FONT="]calculated based on the route of administration. When given[/FONT]
[FONT="]by transdermal delivery, a bioavailability rate of no more[/FONT]
[FONT="]than 10% is assumed. A daily dosage of 4 pellets (100 mg)[/FONT]
[FONT="]would, therefore, provide the equivalent of 70 mg per week[/FONT]
[FONT="]of testosterone propionate (as given by injection). When[/FONT]
[FONT="]given by injection a dose of 100 mg every second or third[/FONT]
[FONT="]day is most common. The drug is generally taken for no more[/FONT]
[FONT="]than 8 weeks, and is used almost exclusively during bulking[/FONT]
[FONT="]phases of training. Those who have experimented with this[/FONT]
[FONT="]product have been generally disappointed with the results, as[/FONT]
[FONT="]the added estrogen has often resulted in rapid gynecomastia,[/FONT]
[FONT="]noticeable body fat accumulation, and severe water retention.[/FONT]
[FONT="]In many cases the water retained has caused an unsightly[/FONT]
[FONT="]bloated look (extreme loss of definition).[/FONT]
[FONT="]Administration (Women):[/FONT]
[FONT="]Synovex is not approved for use in humans. Prescribing[/FONT]
[FONT="]guidelines are unavailable. Synovex is not recommended for[/FONT]
[FONT="]women for physique- or performance-enhancing purposes[/FONT]
[FONT="]due to its strong androgenic nature and tendency to produce[/FONT]
[FONT="]virilizing side effects.[/FONT]
[FONT="]Availability:[/FONT]
[FONT="]Synovex is rarely found on the black market, given that the[/FONT]
[FONT="]product is in poor demand and generally can be obtained[/FONT]
[FONT="]through legitimate Agricultural or Veterinary supply stores.[/FONT]
[FONT="]No counterfeits have ever been known to exist.[/FONT]
[FONT="] [/FONT]
[FONT="]By WL[/FONT][FONT="][/FONT]
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[FONT="]Synovex is a blended-ingredient steroid implant preparation,[/FONT]
[FONT="]which is available only as a veterinary item for use in[/FONT]
[FONT="]cattle.The implant comes in the form of small pellets, which[/FONT]
[FONT="]are pushed into the ear of an animal with a very large implant[/FONT]
[FONT="]gun. Once implanted, the pellets slowly dissolve, providing[/FONT]
[FONT="]an extended release of steroids for many weeks. The[/FONT]
[FONT="]hormone content of Synovex is mixed, with each pellet[/FONT]
[FONT="]containing 25 mg testosterone propionate and 2.5 mg[/FONT]
[FONT="]estradiol benzoate. This 10:1 ratio has been demonstrated to[/FONT]
[FONT="]provide an added anabolic/weight gaining effect in feed[/FONT]
[FONT="]animals, improving the value of the livestock. Given its[/FONT]
[FONT="]estrogen content, Synovex is clearly not an ideal steroid for[/FONT]
[FONT="]humans. Most athletes have only become attracted to this[/FONT]
[FONT="]product out of sheer desperation for legitimate anabolics, as[/FONT]
[FONT="]cattle implants like this are not regulated as controlled[/FONT]
[FONT="]substances in the U.S. to spite their steroid content.[/FONT]
[FONT="]Otherwise, a pure testosterone propionate product would be[/FONT]
[FONT="]much more appropriate.[/FONT]
[FONT="]History:[/FONT]
[FONT="]Testosterone propionate plus estrogen implant pellets were[/FONT]
[FONT="]first approved by the U.S. Food and Drug administration for[/FONT]
[FONT="]use in heifers in 1958.591 Diethylstilbestrol, a potent estrogen[/FONT]
[FONT="]often used to increase animal carcass weight, had been[/FONT]
[FONT="]approved four years earlier for use in cattle, however, and[/FONT]
[FONT="]would remain the leading product for many years. Syntex[/FONT]
[FONT="]introduced their version of testosterone/estrogen pellets[/FONT]
[FONT="](Synovex) during the early 1970’s, as part of the company’s[/FONT]
[FONT="]new Animal Health division. This was during a time a time[/FONT]
[FONT="]when diethylstilbestrol was getting a great deal of negative[/FONT]
[FONT="]publicity. Synovex became a huge seller when the FDA[/FONT]
[FONT="]banned the use of diethylstilbestrol in 1973, the product[/FONT]
[FONT="]quickly capturing more than 50% of the market for growthpromoting[/FONT]
[FONT="]implants. The popularity of Synovex soon caught[/FONT]
[FONT="]the attention of other companies, a number of which soon[/FONT]
[FONT="]started making their own blended testosterone/estrogen[/FONT]
[FONT="]implants. Popular brand names in the U.S. have included FTO[/FONT]
[FONT="](Upjohn), Heifer-oid (Boehringer), and Implus (Upjohn).[/FONT]
[FONT="]Synovex and other testosterone/estrogen pellets remain[/FONT]
[FONT="]widely available in the U.S. and abroad today, although are[/FONT]
[FONT="]not highly popular with athletes given their estrogen content.[/FONT]
[FONT="]How Supplied:[/FONT]
[FONT="]Synovex contains 25 mg of testosterone propionate and 2.5[/FONT]
[FONT="]mg of estradiol benzoate in a small sterile implantation[/FONT]
[FONT="]pellet. The number of pellets in each cartridge dose will vary[/FONT]
[FONT="]depending on the intended target animal. Implants denoted[/FONT]
[FONT="]“H” for heifer will carry the most; in the case of U.S.[/FONT]
[FONT="]Synovex-H it is 80 pellets (10 doses consisting each of 8[/FONT]
[FONT="]pellets). We will see a slightly lower pellet count in the “S”[/FONT]
[FONT="]implants (steer) and “C” (calf ) cartridges.[/FONT]
[FONT="]Structural Characteristics:[/FONT]
[FONT="]Testosterone propionate is a modified form of testosterone,[/FONT]
[FONT="]where a carboxylic acid ester (propionic acid) has been[/FONT]
[FONT="]attached to the 17-beta hydroxyl group to slow the release of[/FONT]
[FONT="]testosterone from the area of implantation. This preparation[/FONT]
[FONT="]also contains an ester (benzoic acid) of estradiol.[/FONT]
[FONT="]Side Effects (Estrogenic):[/FONT]
[FONT="]Testosterone is readily aromatized in the body to estradiol[/FONT]
[FONT="](estrogen). Additionally, this preparation contains an active[/FONT]
[FONT="]estrogen. Elevated estrogen levels can cause side effects[/FONT]
[FONT="]such as increased water retention, body fat gain, and[/FONT]
[FONT="]gynecomastia. This steroid preparation is considered to be[/FONT]
[FONT="]highly estrogenic. An anti-estrogen such as clomiphene[/FONT]
[FONT="]citrate or tamoxifen citrate may be necessary to prevent[/FONT]
[FONT="]estrogenic side effects. One may alternately use an aromatase[/FONT]
[FONT="]inhibitor like Arimidex® (anastrozole), although it will not[/FONT]
[FONT="]have an affect on the additional estrogen present in the[/FONT]
[FONT="]preparation. Since water retention and loss of muscle[/FONT]
[FONT="]definition are common with highly estrogenic steroid[/FONT]
[FONT="]products, this drug is usually considered a poor choice for[/FONT]
[FONT="]dieting or cutting phases of training. It would only be[/FONT]
[FONT="]appropriate during bulking phases, where the added water[/FONT]
[FONT="]retention will support raw strength and muscle size, and help[/FONT]
[FONT="]foster a stronger anabolic environment.[/FONT]
[FONT="]Side Effects (Androgenic):[/FONT]
[FONT="]Testosterone is the primary male androgen, responsible for[/FONT]
[FONT="]maintaining secondary male sexual characteristics. Elevated[/FONT]
[FONT="]levels of testosterone are likely to produce androgenic side[/FONT]
[FONT="]effects including oily skin, acne, and body/facial hair growth.[/FONT]
[FONT="]Men with a genetic predisposition for hair loss (androgenetic[/FONT]
[FONT="]alopecia) may notice accelerated male pattern balding.[/FONT]
[FONT="]Those concerned about hair loss may find a more[/FONT]
[FONT="]comfortable option in nandrolone decanoate, which is a[/FONT]
[FONT="]comparably less androgenic steroid. Women are warned of[/FONT]
[FONT="]the potential virilizing effects of anabolic/androgenic[/FONT]
[FONT="]steroids, especially with a strong androgen such as[/FONT]
[FONT="]testosterone. These may include deepening of the voice,[/FONT]
[FONT="]menstrual irregularities, changes in skin texture, facial hair[/FONT]
[FONT="]growth, and clitoral enlargement.[/FONT]
[FONT="]Side Effects (Hepatotoxicity):[/FONT]
[FONT="]Testosterone and estrogen do not have hepatotoxic effects;[/FONT]
[FONT="]liver toxicity is unlikely.[/FONT]
[FONT="]Side Effects (Cardiovascular):[/FONT]
[FONT="]Anabolic/androgenic steroids can have deleterious effects on[/FONT]
[FONT="]serum cholesterol. This includes a tendency to reduce HDL[/FONT]
[FONT="](good) cholesterol values and increase LDL (bad)[/FONT]
[FONT="]cholesterol values, which may shift the HDL to LDL balance[/FONT]
[FONT="]in a direction that favors greater risk of arteriosclerosis. The[/FONT]
[FONT="]relative impact of an anabolic/androgenic steroid on serum[/FONT]
[FONT="]lipids is dependant on the dose, route of administration (oral[/FONT]
[FONT="]vs. injectable), type of steroid (aromatizable or nonaromatizable),[/FONT]
[FONT="]and level of resistance to hepatic metabolism.[/FONT]
[FONT="]Testosterone tends to have a much less dramatic impact on[/FONT]
[FONT="]cardiovascular risk factors than synthetic steroids. This is[/FONT]
[FONT="]due in part to its openness to metabolism by the liver, which[/FONT]
[FONT="]allows it to have less effect on the hepatic management of[/FONT]
[FONT="]cholesterol. The aromatization of testosterone to estradiol[/FONT]
[FONT="]also helps to mitigate the negative effects of androgens on[/FONT]
[FONT="]serum lipids. The added estrogen in this product may further[/FONT]
[FONT="]help to offset some of the androgenic effect on lipid values,[/FONT]
[FONT="]and the preparation may, therefore, have a weaker impact on[/FONT]
[FONT="]cholesterol than a comparably dosed straight testosterone[/FONT]
[FONT="]product. Anabolic/androgenic steroids may also adversely[/FONT]
[FONT="]affect blood pressure and triglycerides, reduce endothelial[/FONT]
[FONT="]relaxation, and support left ventricular hypertrophy, all[/FONT]
[FONT="]potentially increasing the risk of cardiovascular disease and[/FONT]
[FONT="]myocardial infarction.[/FONT]
[FONT="]Side Effects (Testosterone Suppression):[/FONT]
[FONT="]All anabolic/androgenic steroids when taken in doses[/FONT]
[FONT="]sufficient to promote muscle gain are expected to suppress[/FONT]
[FONT="]endogenous testosterone production. Testosterone is the[/FONT]
[FONT="]primary male androgen, and offers strong negative feedback[/FONT]
[FONT="]on endogenous testosterone production. The added estrogen[/FONT]
[FONT="]will also provide negative-feedback suppression. This[/FONT]
[FONT="]preparation should have a strong effect on the hypothalamic[/FONT]
[FONT="]regulation of natural steroid hormones. Without the[/FONT]
[FONT="]intervention of testosterone stimulating substances,[/FONT]
[FONT="]testosterone levels should return to normal within 1-4 months[/FONT]
[FONT="]of drug secession. Note that prolonged hypogonadotrophic[/FONT]
[FONT="]hypogonadism can develop secondary to steroid abuse,[/FONT]
[FONT="]necessitating medical intervention.[/FONT]
[FONT="]To help reduce cardiovascular strain it is advised to[/FONT]
[FONT="]maintain an active cardiovascular exercise program and[/FONT]
[FONT="]minimize the intake of saturated fats, cholesterol, and simple[/FONT]
[FONT="]carbohydrates at all times during active AAS administration.[/FONT]
[FONT="]Supplementing with fish oils (4 grams per day) and a natural[/FONT]
[FONT="]cholesterol/antioxidant formula such as Lipid Stabil or a[/FONT]
[FONT="]product with comparable ingredients is also recommended.[/FONT]
[FONT="]Administration (General):[/FONT]
[FONT="]Synovex implant pellets were not designed for human[/FONT]
[FONT="]consumption. To make use of these pellets, they must be[/FONT]
[FONT="]converted into another (more suitable) delivery form. To do[/FONT]
[FONT="]this, an athlete will typically grind them up and rub them on[/FONT]
[FONT="]the skin in a 50/50 mixture of DMSO and water to facilitate[/FONT]
[FONT="]transdermal delivery. Alternately, one may mix up a[/FONT]
[FONT="]homebrew injection with the pellets. This is done by grinding[/FONT]
[FONT="]them into a fine powder and introducing the powder into[/FONT]
[FONT="]filtered oil or an oil-based steroid. One should remember[/FONT]
[FONT="]that the practice of preparing Synovex for injection is not[/FONT]
[FONT="]going to be sterile, and as such could be potentially[/FONT]
[FONT="]dangerous. Note that some methods have additionally been[/FONT]
[FONT="]published for removing the estrogen from the pellets, to make[/FONT]
[FONT="]the drug more comfortable to use. They generally involve the[/FONT]
[FONT="]use of highly flammable materials, take a number of different[/FONT]
[FONT="]steps to complete, and leave some estrogen when the process[/FONT]
[FONT="]is over, however, usually making the process more trouble[/FONT]
[FONT="]than it is worth.[/FONT]
[FONT="]Administration (Men):[/FONT]
[FONT="]Synovex is not approved for use in humans. Prescribing[/FONT]
[FONT="]guidelines are unavailable. When used for physique- or[/FONT]
[FONT="]performance-enhancing purposes (very rarely), the dose is[/FONT]
[FONT="]calculated based on the route of administration. When given[/FONT]
[FONT="]by transdermal delivery, a bioavailability rate of no more[/FONT]
[FONT="]than 10% is assumed. A daily dosage of 4 pellets (100 mg)[/FONT]
[FONT="]would, therefore, provide the equivalent of 70 mg per week[/FONT]
[FONT="]of testosterone propionate (as given by injection). When[/FONT]
[FONT="]given by injection a dose of 100 mg every second or third[/FONT]
[FONT="]day is most common. The drug is generally taken for no more[/FONT]
[FONT="]than 8 weeks, and is used almost exclusively during bulking[/FONT]
[FONT="]phases of training. Those who have experimented with this[/FONT]
[FONT="]product have been generally disappointed with the results, as[/FONT]
[FONT="]the added estrogen has often resulted in rapid gynecomastia,[/FONT]
[FONT="]noticeable body fat accumulation, and severe water retention.[/FONT]
[FONT="]In many cases the water retained has caused an unsightly[/FONT]
[FONT="]bloated look (extreme loss of definition).[/FONT]
[FONT="]Administration (Women):[/FONT]
[FONT="]Synovex is not approved for use in humans. Prescribing[/FONT]
[FONT="]guidelines are unavailable. Synovex is not recommended for[/FONT]
[FONT="]women for physique- or performance-enhancing purposes[/FONT]
[FONT="]due to its strong androgenic nature and tendency to produce[/FONT]
[FONT="]virilizing side effects.[/FONT]
[FONT="]Availability:[/FONT]
[FONT="]Synovex is rarely found on the black market, given that the[/FONT]
[FONT="]product is in poor demand and generally can be obtained[/FONT]
[FONT="]through legitimate Agricultural or Veterinary supply stores.[/FONT]
[FONT="]No counterfeits have ever been known to exist.[/FONT]
[FONT="] [/FONT]
[FONT="]By WL[/FONT][FONT="][/FONT]
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