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View Full Version : Oreton (testosterone propionate) anabolic androgenic injectable steroid profile



akn
07-10-2014, 09:37 PM
<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves/> <w:TrackFormatting/> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF/> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> <w:SplitPgBreakAndParaMark/> <w:DontVertAlignCellWithSp/> <w:DontBreakConstrainedForcedTables/> <w:DontVertAlignInTxbx/> <w:Word11KerningPairs/> <w:CachedColBalance/> <w:UseFELayout/> </w:Compatibility> <w:DoNotOptimizeForBrowser/> <m:mathPr> <m:mathFont m:val="Cambria Math"/> <m:brkBin m:val="before"/> <m:brkBinSub m:val="--"/> <m:smallFrac m:val="off"/> <m:dispDef/> <m:lMargin m:val="0"/> <m:rMargin m:val="0"/> <m:defJc m:val="centerGroup"/> <m:wrapIndent m:val="1440"/> <m:intLim m:val="subSup"/> <m:naryLim m:val="undOvr"/> </m:mathPr></w:WordDocument> </xml><![endif]--> Description:
Testosterone propionate is a commonly manufactured
injectable form of the primary male androgen testosterone.
The added propionate ester will slow the rate in which
testosterone is released from the injection site, but only for a
few days. Testosterone propionate is, therefore,
comparatively much faster-acting than other testosterone
esters such as cypionate or enanthate, and requires a much
more frequent dosing schedule. By most accounts
testosterone propionate is an older and cruder form of
injectable testosterone, made obsolete by the slower-acting
and more comfortable esters that were developed subsequent
to it. Still, those who are not bothered by the frequent
injection schedule find testosterone propionate every bit as
acceptable. As an injectable testosterone, it is a powerful
mass-building drug, capable of producing rapid gains in both
muscle size and strength.
History:
Testosterone propionate was first described in 1935, during
a series of experiments that set out to increase the therapeutic
usefulness of testosterone by slowing its release into the
bloodstream.566 Two years later, Schering AG in Germany
would introduce the first testosterone propionate product
under the brand name Testoviron®. Propionate was also the
first commercially available injectable ester of testosterone
on the U.S. prescription drug market, and remained the
dominant form of testosterone globally before 1960. Back
during the early 1950’s, for example, when steroids were
first being experimented with by small numbers of American
athletes, the only readily available anabolic/androgenic
steroids were methyltestosterone, testosterone propionate,
and testosterone suspension. Interesting enough, during this
time testosterone propionate was also available in orally
administered (Buccal) preparations, but they disappeared
from the U.S. market during the 1980’s.
Early prescribing guidelines for testosterone propionate
called for a number of therapeutic uses. It was mainly
applied to cases of male androgen insufficiency, and those
issues normally surrounding low testosterone levels such as
reduced sex drive and impotence in adults, and
cryptorchidism (undescended testicles) in teenagers and
young adults. But it also had such other uses as treating
menopause, menorrhagia (heavy menstrual bleeding),
menstrual tension, chronic cystic mastitis (fibrocystic
breasts), endometriosis, and excessive lactation, covering a
wide range of situations in which the male hormone
testosterone was being applied to female patients. Over the
years these wide guidelines were narrowed by the U.S. Food
& Drug Administration, however, and by the 1980’s,
testosterone propionate was being largely applied only to
male patients.
Testosterone propionate has a long history of availability in
the U.S. and abroad, and remains a very common form of
testosterone on the global market to this day. It must be
emphasized, however, that its ability to remain on the market
is more a product of history than unique application.
Testosterone propionate was the first acceptable ester of
testosterone, and consequently has many decades of history
as a useable therapeutic agent. Many companies have sold it
for decades now, and so long as it is still in demand will
continue to do so. But other (more modern) forms of
testosterone such as enanthate and cypionate are much more
popular today, as they are much slower-acting still, and
allow for far more comfortable administration schedules.
Testosterone propionate is still approved for sale in the
United States, although its ultimate market future here
remains questionable.
Bodybuilders commonly consider propionate to be the
mildest testosterone ester, and the preferred form of this
hormone for dieting/cutting phases of training. Some will go
so far as to say that propionate will harden the physique,
while giving the user less water and fat retention than one
typically expects to see with a testosterone like enanthate,
cypionate or Sustanon. Realistically, however, these
advantages do not hold up to close scrutiny. The propionate
ester is actually removed before the testosterone it carries is
active in the body, and ultimately has little effect outside of
slowing steroid release. It all really boils down to how much
testosterone you are getting into your blood with each
particular esterified compound. Otherwise, there are no real
functional differences between them.
How Supplied:
Testosterone propionate is widely available in human and
veterinary drug markets. Composition and dosage may vary
by country and manufacturer, but usually contain 25 mg/ml,
50 mg/ml, or 100 mg/ml of steroid dissolved in oil.

Structural Characteristics:
Testosterone propionate is a modified form of testosterone,
where a carboxylic acid ester (propionic acid) has been
attached to the 17-beta hydroxyl group. Esterified forms of
testosterone are less polar than free testosterone, and are
absorbed more slowly from the area of injection. Once in the
bloodstream, the ester is removed to yield free (active)
testosterone. Esterified forms of testosterone are designed to
prolong the window of therapeutic effect following
administration, allowing for a less frequent injection
schedule compared to injections of free (unesterified)
steroid. The half-life of testosterone propionate is
approximately two days after injection.
Side Effects (Estrogenic):
Testosterone is readily aromatized in the body to estradiol
(estrogen). The aromatase (estrogen synthetase) enzyme is
responsible for this metabolism of testosterone. Elevated
estrogen levels can cause side effects such as increased
water retention, body fat gain, and gynecomastia.
Testosterone is considered a moderately estrogenic steroid.
An anti-estrogen such as clomiphene citrate or tamoxifen
citrate may be necessary to prevent estrogenic side effects.
One may alternately use an aromatase inhibitor like
Arimidex® (anastrozole), which more efficiently controls
estrogen by preventing its synthesis. Aromatase inhibitors
can be quite expensive in comparison to anti-estrogens,
however, and may also have negative effects on blood lipids.
Estrogenic side effects will occur in a dose-dependant
manner, with higher doses (above normal therapeutic levels)
of testosterone propionate more likely to require the
concurrent use of an anti-estrogen or aromatase inhibitor.
Since water retention and loss of muscle definition are
common with higher doses of testosterone, this drug is
usually considered a poor choice for dieting or cutting
phases of training. Its moderate estrogenicity makes it more
ideal for bulking phases, where the added water retention
will support raw strength and muscle size, and help foster a
stronger anabolic environment.
Side Effects (Androgenic):
Testosterone is the primary male androgen, responsible for
maintaining secondary male sexual characteristics. Elevated
levels of testosterone are likely to produce androgenic side
effects including oily skin, acne, and body/facial hair growth.
Men with a genetic predisposition for hair loss (androgenetic
alopecia) may notice accelerated male pattern balding.
Those concerned about hair loss may find a more
comfortable option in nandrolone decanoate, which is a
comparably less androgenic steroid. Women are warned of
the potential virilizing effects of anabolic/androgenic
steroids, especially with a strong androgen such as
testosterone. These may include deepening of the voice,
menstrual irregularities, changes in skin texture, facial hair
growth, and clitoral enlargement.
In androgen-responsive target tissues such as the skin, scalp,
and prostate, the high relative androgenicity of testosterone is
dependant on its reduction to dihydrotestosterone (DHT).
The 5-alpha reductase enzyme is responsible for this
metabolism of testosterone. The concurrent use of a 5-alpha
reductase inhibitor such as finasteride or dutasteride will
interfere with site-specific potentiation of testosterone
action, lowering the tendency of testosterone drugs to
produce androgenic side effects. It is important to remember
that both anabolic and androgenic effects are mediated via
the cytosolic androgen receptor. Complete separation of
testosterone’s anabolic and androgenic properties is not
possible, even with total 5-alpha reductase inhibition.
Side Effects (Hepatotoxicity):
Testosterone does not have hepatotoxic effects; liver toxicity
is unlikely. One study examined the potential for
hepatotoxicity with high doses of testosterone by
administering 400 mg of the hormone per day (2,800 mg per
week) to a group of male subjects. The steroid was taken
orally so that higher peak concentrations would be reached in
hepatic tissues compared to intramuscular injections. The
hormone was given daily for 20 days, and produced no
significant changes in liver enzyme values including serum
albumin, bilirubin, alanine-amino-transferase, and alkaline
phosphatases.567
Side Effects (Cardiovascular):
Anabolic/androgenic steroids can have deleterious effects on
serum cholesterol. This includes a tendency to reduce HDL
(good) cholesterol values and increase LDL (bad)
cholesterol values, which may shift the HDL to LDL balance
in a direction that favors greater risk of arteriosclerosis. The
relative impact of an anabolic/androgenic steroid on serum
lipids is dependant on the dose, route of administration (oral
vs. injectable), type of steroid (aromatizable or nonaromatizable),
and level of resistance to hepatic metabolism.
Anabolic/androgenic steroids may also adversely affect
blood pressure and triglycerides, reduce endothelial
relaxation, and support left ventricular hypertrophy, all
potentially increasing the risk of cardiovascular disease and
myocardial infarction.
Testosterone tends to have a much less dramatic impact on
cardiovascular risk factors than synthetic steroids. This is
due in part to its openness to metabolism by the liver, which
allows it to have less effect on the hepatic management of
cholesterol. The aromatization of testosterone to estradiol
also helps to mitigate the negative effects of androgens on
serum lipids. In one study, 280 mg per week of testosterone
ester (enanthate) had a slight but not statistically significant
effect on HDL cholesterol after 12 weeks, but when taken
with an aromatase inhibitor a strong (25%) decrease was
seen.568 Studies using 300 mg of testosterone ester
(enanthate) per week for twenty weeks without an aromatase
inhibitor demonstrated only a 13% decrease in HDL
cholesterol, while at 600 mg the reduction reached 21%.569
The negative impact of aromatase inhibition should be taken
into consideration before such drug is added to testosterone
therapy.
Due to the positive influence of estrogen on serum lipids,
tamoxifen citrate or clomiphene citrate are preferred to
aromatase inhibitors for those concerned with cardiovascular
health, as they offer a partial estrogenic effect in the liver.
This allows them to potentially improve lipid profiles and
offset some of the negative effects of androgens. With doses
of 600 mg or less of testosterone per week, the impact on
lipid profile tends to be noticeable but not dramatic, making
an anti-estrogen (for cardioprotective purposes) perhaps
unnecessary. Doses of 600 mg or less per week have also
failed to produce statistically significant changes in
LDL/VLDL cholesterol, triglycerides, apolipoprotein B/CIII,
C-reactive protein, and insulin sensitivity, all indicating a
relatively weak impact on cardiovascular risk factors.570
When used in moderate doses, injectable testosterone esters
are usually considered to be the safest of all
anabolic/androgenic steroids.
To help reduce cardiovascular strain it is advised to
maintain an active cardiovascular exercise program and
minimize the intake of saturated fats, cholesterol, and simple
carbohydrates at all times during active AAS administration
Supplementing with fish oils (4 grams per day) and a natural
cholesterol/antioxidant formula such as Lipid Stabil or a
product with comparable ingredients is also recommended.
Side Effects (Testosterone Suppression):
All anabolic/androgenic steroids when taken in doses
sufficient to promote muscle gain are expected to suppress
endogenous testosterone production. Testosterone is the
primary male androgen, and offers strong negative feedback
on endogenous testosterone production. Testosterone-based
drugs will, likewise, have a strong effect on the hypothalamic
regulation of natural steroid hormones. Without the
intervention of testosterone-stimulating substances,
testosterone levels should return to normal within 1-4 months
of drug secession. Note that prolonged hypogonadotrophic
hypogonadism can develop secondary to steroid abuse,
necessitating medical intervention.
Administration (General):
Testosterone propionate is often regarded as a painful
injection. This is due to the very short carbon chain of the
propionic acid ester, which can be irritating to tissues at the
site of injection. Many sensitive individuals choose to stay
away from this steroid completely, their bodies reacting with
a pronounced soreness and low-grade fever that may last for
a few days after each injection. Even the mild soreness that
is experienced by most users can be quite uncomfortable,
especially when you take into account that the drug is being
administered multiple times each week for a number of
consecutive weeks.
Administration (Men):
To treat androgen insufficiency, early prescribing guidelines
recommended a dosage of 25 mg given two to three times per
week. Modern product literature usually recommends 25 mg
to 50 mg given two to three times per week for the same
purpose. The usual dosage among male athletes is in the
range of 50-100 mg per injection, which is given every
second or third day. Similar to other esters of testosterone,
testosterone propionate is commonly used at a weekly
cumulative dosage between 200 mg to 400 mg. This level is
sufficient for most users to notice exceptional gains in muscle
size and strength.
Testosterone propionate is usually incorporated into bulking
phases of training, when added water retention will be of
little consequence, the user more concerned with raw mass
than definition. Some do incorporate this drug into cutting
cycles as well, but typically in lower doses (100-200 mg per
week) and/or when accompanied by an aromatase inhibitor
to keep estrogen levels under control. Testosterone
propionate is a very effective anabolic drug, and is often
used alone with great benefit. Some, however, find a need to
stack it with other anabolic/androgenic steroids for a
stronger effect, in which case an additional 200-400 mg per
week of boldenone undecylenate, methenolone enanthate, or
nandrolone decanoate should provide substantial results with
no significant hepatotoxicity. Testosterone is ultimately very
versatile, and can be combined with many other
anabolic/androgenic steroids to tailor the desired effect.
Administration (Women):
Testosterone propionate is rarely used with women in
clinical medicine. When applied, it is most often used as a
secondary medication during inoperable breast cancer, when
other therapies have failed to produce a desirable effect and
suppression of ovarian function is necessary. Testosterone
propionate is not recommended for women for performanceenhancing
purposes due to its strong androgenic nature and
tendency to produce virilizing side effects. Female
bodybuilders who insist on using testosterone, however,
often choose propionate, as blood levels are easier to control
with this ester compared to cypionate or enanthate. Should
virilization symptoms develop, hormone levels will decline
in a matter of days, instead of weeks, following drug
cessation. The administration schedule is often more
conservative as well, with a small injection (25 mg at most)
given every 5 to 7 days, and cycle duration limited to 6-8
weeks or less.

By WL
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