Sustanon® 100(testosterone blend) anabolic androgenic steroid profile

akn · Jul 13, 2014

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Sustanon® 100 is an oil-based injectable testosterone blend
that contains three different testosterone esters: testosterone
propionate (20 mg); testosterone phenylpropionate (40 mg);
and testosterone isocaproate (40 mg). This product is
manufactured by Organon, and is essentially a lower dosed
version of their Sustanon® 250. Like Sustanon® 250,
Sustanon® 100 makes use of multiple esters of testosterone
to produce a desired slow-acting effect. The different esters
have different levels of oil solubility, and likewise rates of
release from the site of injection. The design is such that the
rapid distribution of testosterone is followed by a sustained
release of hormone. Sustanon® 100 is shorter acting than
Sustanon® 250, as it lacks the longer decanoate ester, and is
usually administered on a biweekly basis. This drug is
ultimately very similar to testosterone cypionate or enanthate,
but with a slightly shorter window of therapeutic effect.
History:
Sustanon® 100 is a modern adaptation of the well-known
injectable testosterone blend Sustanon® 250, both of which
were developed by the international pharmaceutical giant
Organon (now Merck/MSD). Sustanon® 100 is essentially a
lower dosed equivalent of Sustanon® 250, supplying the
same hormone in a similar (though not exact) time-released
fashion. Sustanon® 100 is recommended for the same
medical uses as Sustanon® 250, namely treating male
androgen insufficiency, which can manifest itself with such
symptoms as reduced sex drive, impotence, infertility, and
bone loss. Increased adiposity (fat mass) and reduced lean
mass are also common with patients suffering from low
androgen levels. In addition to these uses, Sustanon® 100 is
also recommended to induce masculinization in female-tomale
transsexuals. Sustanon® 100 is produced only in a
handful of countries at this time, and is not widely available.
How Supplied:
Sustanon® 100 is available in select human drug markets.
All products are supplied in 1 mL glass ampules.
Structural Characteristics:
Sustanon® 100 contains a mixture of three testosterone
compounds, which where modified with the addition of
carboxylic acid esters (propionic, propionic phenyl ester,
and isocaproic acids) at the 17-beta hydroxyl group.
Esterified forms of testosterone are less polar than free
testosterone, and are absorbed more slowly from the area of
injection. Once in the bloodstream, the ester is removed to
yield free (active) testosterone. Esterified forms of
testosterone are designed to prolong the window of
therapeutic effect following administration, allowing for a
less frequent injection schedule compared to injections of
free (unesterified) steroid. Sustanon 100 is designed to
provide a rapid peak in testosterone levels (24-48 hours
after injection), and maintain physiological concentrations
for approximately 14 days.
Side Effects (Estrogenic):
Testosterone is readily aromatized in the body to estradiol
(estrogen). The aromatase (estrogen synthetase) enzyme is
responsible for this metabolism of testosterone. Elevated
estrogen levels can cause side effects such as increased
water retention, body fat gain, and gynecomastia.
Testosterone is considered a moderately estrogenic steroid.
An anti-estrogen such as clomiphene citrate or tamoxifen
citrate may be necessary to prevent estrogenic side effects.
One may alternately use an aromatase inhibitor like
Arimidex® (anastrozole), which more efficiently controls
estrogen by preventing its synthesis. Aromatase inhibitors
can be quite expensive in comparison to anti-estrogens,
however, and may also have negative effects on blood lipids.
Estrogenic side effects will occur in a dose-dependant
manner, with higher doses (above normal therapeutic levels)
of testosterone more likely to require the concurrent use of an
anti-estrogen or aromatase inhibitor. Since water retention
and loss of muscle definition are common with higher doses
of testosterone, this drug is usually considered a poor choice
for dieting or cutting phases of training. Its moderate
estrogenicity makes it more ideal for bulking phases, where
the added water retention will support raw strength and
muscle size, and help foster a stronger anabolic environment.
Side Effects (Androgenic):
Testosterone is the primary male androgen, responsible for
maintaining secondary male sexual characteristics. Elevated
levels of testosterone are likely to produce androgenic side
effects including oily skin, acne, and body/facial hair growth.
Men with a genetic predisposition for hair loss (androgenetic
alopecia) may notice accelerated male pattern balding.
Those concerned about hair loss may find a more
comfortable option in nandrolone decanoate, which is a
comparably less androgenic steroid. Women are warned of
the potential virilizing effects of anabolic/androgenic
steroids, especially with a strong androgen such as
testosterone. These may include deepening of the voice,
menstrual irregularities, changes in skin texture, facial hair
growth, and clitoral enlargement.
In androgen-responsive target tissues such as the skin, scalp,
and prostate, the high relative androgenicity of testosterone is
dependant on its reduction to dihydrotestosterone (DHT).
The 5-alpha reductase enzyme is responsible for this
metabolism of testosterone. The concurrent use of a 5-alpha
reductase inhibitor such as finasteride or dutasteride will
interfere with site-specific potentiation of testosterone
action, lowering the tendency of testosterone drugs to
produce androgenic side effects. It is important to remember
that anabolic and androgenic effects are both mediated via
the cytosolic androgen receptor. Complete separation of
testosterone’s anabolic and androgenic properties is not
possible, even with total 5-alpha reductase inhibition.
Side Effects (Hepatotoxicity):
Testosterone does not have hepatotoxic effects; liver toxicity
is unlikely. One study examined the potential for
hepatotoxicity with high doses of testosterone by
administering 400 mg of the hormone per day (2,800 mg per
week) to a group of male subjects. The steroid was taken
orally so that higher peak concentrations would be reached in
hepatic tissues compared to intramuscular injections. The
hormone was given daily for 20 days, and produced no
significant changes in liver enzyme values including serum
albumin, bilirubin, alanine-amino-transferase, and alkaline
phosphatases.582
Side Effects (Cardiovascular):
Anabolic/androgenic steroids can have deleterious effects on
serum cholesterol. This includes a tendency to reduce HDL
(good) cholesterol values and increase LDL (bad)
cholesterol values, which may shift the HDL to LDL balance
in a direction that favors greater risk of arteriosclerosis. The
relative impact of an anabolic/androgenic steroid on serum
lipids is dependant on the dose, route of administration (oral
vs. injectable), type of steroid (aromatizable or nonaromatizable),
and level of resistance to hepatic metabolism.
Anabolic/androgenic steroids may also adversely affect
blood pressure and triglycerides, reduce endothelial
relaxation, and support left ventricular hypertrophy, all
potentially increasing the risk of cardiovascular disease and
myocardial infarction.
Testosterone tends to have a much less dramatic impact on
cardiovascular risk factors than synthetic steroids. This is
due in part to its openness to metabolism by the liver, which
allows it to have less effect on the hepatic management of
cholesterol. The aromatization of testosterone to estradiol
also helps to mitigate the negative effects of androgens on
serum lipids. In one study, 280 mg per week of testosterone
ester (enanthate) had a slight but not statistically significant
effect on HDL cholesterol after 12 weeks, but when taken
with an aromatase inhibitor a strong (25%) decrease was
seen.583 Studies using 300 mg of testosterone ester
(enanthate) per week for 20 weeks without an aromatase
inhibitor demonstrated only a 13% decrease in HDL
cholesterol, while at 600 mg the reduction reached 21%.584
The negative impact of aromatase inhibition should be taken
into consideration before such drug is added to testosterone
therapy.
Due to the positive influence of estrogen on serum lipids,
tamoxifen citrate or clomiphene citrate are preferred to
aromatase inhibitors for those concerned with cardiovascular
health, as they offer a partial estrogenic effect in the liver.
This allows them to potentially improve lipid profiles and
offset some of the negative effects of androgens. With doses
of 600 mg or less of testosterone per week, the impact on
lipid profile tends to be noticeable but not dramatic, making
an anti-estrogen (for cardioprotective purposes) perhaps
unnecessary. Doses of 600 mg or less per week have also
failed to produce statistically significant changes in
LDL/VLDL cholesterol, triglycerides, apolipoprotein B/CIII,
C-reactive protein, and insulin sensitivity, all indicating a
relatively weak impact on cardiovascular risk factors.585
When used in moderate doses,injectable testosterone esters
are usually considered to be the safest of all
anabolic/androgenic steroids.
To help reduce cardiovascular strain it is advised to
maintain an active cardiovascular exercise program and
minimize the intake of saturated fats, cholesterol, and simple
carbohydrates at all times during active AAS administration.
Supplementing with fish oils (4 grams per day) and a natural
cholesterol/antioxidant formula such as Lipid Stabil or a
product with comparable ingredients is also recommended.
Side Effects (Testosterone Suppression):
All anabolic/androgenic steroids when taken in doses
sufficient to promote muscle gain are expected to suppress
endogenous testosterone production. Testosterone is the
primary male androgen, and offers strong negative feedback
on endogenous testosterone production. Testosterone-based
drugs will, likewise, have a strong effect on the hypothalamic
regulation of natural steroid hormones. Without the
intervention of testosterone-stimulating substances,
testosterone levels should return to normal within 1-4 months
of drug secession. Note that prolonged hypogonadotrophic
hypogonadism can develop secondary to steroid abuse,
necessitating medical intervention
Administration (General):
Testosterone propionate is often regarded as a painful
injection. This is due to the very short carbon chain of the
propionic acid ester, which can be irritating to tissues at the
site of injection. Many sensitive individuals choose to stay
away from this steroid completely, their bodies reacting with
a pronounced soreness and low-grade fever that may last for
a few days after each injection.
Administration (Men):
To treat androgen insufficiency, the prescribing guidelines
for Sustanon® 100 call for a dosage of 100 mg (1 ampule)
every 2 weeks. Although active in the body for a longer time
Sustanon® 100 is usually injected every 7 to 10 days for
muscle-building purposes. This schedule will allow for the
higher doses most commonly applied by athletes, and more
stable elevations in hormone level. The usual dosage among
male athletes is in the range of 200-600 mg per week, taken
in cycles 6 to 12 weeks in length. This level is sufficient for
most users to notice exceptional gains in muscle size and
strength. Testosterone is ultimately very versatile, and can be
combined with many other anabolic/androgenic steroids
depending on the desired effect.
Administration (Women):
Sustanon® 100 is rarely used with women in clinical
medicine. When applied, it is most often used to induce
masculinization in female to male transsexuals. Sustanon®
100 is not recommended for women for physique- or
performance-enhancing purposes due to its strong androgenic
nature, tendency to produce virilizing side effects, and slowacting
characteristics (making blood levels difficult to
control).
Availability:
Sustanon® 100 is less widely distributed on the black market
than Sustanon® 250, due to the fact that source countries
producing this drug are limited. The moderate total amount of
drug contained in each ampule (100 mg) also makes this
product far less desirable to consumers than Sustanon® 250.
Sustanon® 100 is mainly located in the Netherlands, Egypt,
and the United Kingdom

Presser · Jul 15, 2014

good post, i never heard of this 100mg sustanon

Sustanon® 100(testosterone blend) anabolic androgenic steroid profile

akn

Musclechemistry Member

Presser

Admin

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