guardianactual
MuscleChemistry Registered Member
by Jonny Bowden, PhD, CNS
The Case for Supplementation
Ask your typical mainstream doctor about nutritional supplements, and the first thing you're likely to hear is this: "There's no good research showing they work." I've heard this refrain time and time again when I discuss nutritional medicine with my more conservative colleagues.
It's not true.
You or your doctor can go online to the National Institute of Medicine's library, 301 Moved Permanently, put into the search box virtually any vitamin or herb you can think of and, depending on what you choose, hundreds to thousands of citations will pop up. So the problem isn't an absence of research.
The problem is twofold. One, the conventional training of medical doctors in this country is highly biased toward pharmaceuticals. From the time they enter med school, doctors are courted by the pharmaceutical companies in myriad ways, some subtle, some not-so-subtle.
Free lunches, symposiums, honorariums, consulting and lecturing contracts, vacations, perky pharmaceutical reps showing up at offices with the latest studies that show their products in a favorable light, and free samples all create a culture in which pharmaceuticals are the first choice in any treatment plan.
Most docs will tell you these practices have no influence on them or what they choose to prescribe, but the research tells a very different story.2,3
The other part of the problem is that much of the research on vitamins flies beneath the radar. Your overworked doctor barely has time to scan the abstracts of the New England Journal of Medicine every month, let alone dig deeply into the hundreds of studies that are published every year on vitamins and nutrients in journals such as the American Journal of Clinical Nutrition.
The vast majority of doctors in this country get no training whatsoever in nutrition, and those who do receive only the most rudimentary and superficial introduction to the subject. Put this together with the built-in medical school bias in favor of patent medicines, and it's easy to see why doctors often fail to think of natural substances as legitimate tools for keeping people healthy.
The New "Medicine" Cabinet
Many supplements are beneficial for heart health. Here's a short guide to the most important ones. If you're not taking these, perhaps you should be.
Omega-3'S /// The Wellness Molecule
Omega-3's are among the most anti-inflammatory substances on the planet and should be part of everyone's heart-healthy nutrition program. Come to think of it, they should probably be part of everyone's nutrition program, period!
Coenzyme Q10 /// Fuel For The Heart
CoEnzyme Q10 is fuel for the heart. It's made in every cell in the body, and your ability to make it diminishes with age. It's virtually unavailable in any meaningful amount from food. It's also depleted by cholesterol-lowering medications, so if you're on one of those you simply must consider supplementing with Coenzyme Q10 on a daily basis!
D-Ribose /// The Energy Maker
D-Ribose is a five-carbon sugar and one of the components of ATP, the energy molecule the body uses to power all activities. Without D-ribose, there is no ATP; without ATP, there is no energy.
L-Carnitine /// The Energy Transport System
Carnitine acts as a kind of shuttle bus, loading up fatty acids and transporting them into tiny structures within the cell called the mitochondria, where they can be burned for energy. Because the heart receives 60 percent of its energy from fat, it's very important that the body has enough L-carnitine to shuttle the fatty acids into the heart's muscle cells.
Magnesium /// The Great Relaxer
Magnesium supplements are a must for those who want to protect their heart. Magnesium lowers blood pressure, helps control blood sugar and relaxes the lining of the blood vessels. And almost all dietary surveys show that Americans aren't getting nearly enough.
When magnesium is depleted, intracellular calcium rises. Magnesium also inhibits platelet aggregation, an important step toward the development of clots.
Calcium channel blockers like Procardia, Adalat, Plendil, and Cardene widen and relax the blood vessels by affecting the muscle cells found in the arterial walls, which is exactly what magnesium does—splendidly, we might add.
Pantethine /// Your Secret Weapon
Pantethine is a metabolically active—and somewhat more expensive—form of Vitamin B-5, or pantothenic acid. The blood tests of patients with dyslypiemia—meaning their blood cholesterol levels are too high—significantly improve with pantethine. And though it's not seen on a blood test, pantethine also reduces the oxidation of LDL.4
No fewer than 28 clinical trials in humans have shown that pantethine produces significant positive changes in triglycerides, LDL cholesterol, and VLDL, along with increases in HDL cholesterol.5 In all of these trials, virtually no adverse effects were noted. The mean dose of pantethine in these studies was 900 milligrams a day, given as 300 mg three times daily. That appears to be the optimal dose, and it's the one I recommend.
Vitamin C /// Powerful Antioxidant
Vitamin C is one of the most powerful antioxidants in the world, and because heart disease is initiated by oxidative damage caused by free radicals, any help you can get in the antioxidant department is a good thing.
And it's not just theoretical: a large 2011 study in the American Heart Journal found that the lower the level of vitamin C in the blood, the higher the risk for heart failure.6 Take 1,000 to 2,000 mg a day.
Curcumin /// The New Superstar Of Supplements
This extract from the Indian spice turmeric has multiple benefits, not the least of which is that it's highly anti-inflammatory. Scientific research has demonstrated its anti-inflammatory, anti-oxidant, anti-thrombotic, and cardiovascular protective effects.7 It also reduces oxidized LDL cholesterol.8
Resveratrol /// Not Just For Anti-Aging
Resveratrol is the ingredient in red wine that's best known for its "anti-aging" activity. It helps protect the arteries, improves their elasticity, inhibits blood clots, and lowers both oxidized LDL and blood pressure.9 Not a bad resume!
It's both a strong anti-oxidant and a strong anti-inflammatory, inhibiting a number of inflammatory enzymes that can contribute to heart disease. It also inhibits the ability of certain molecules to stick to the walls of the artery, where they can take up residence and contribute to inflammation.10
The recommended dose is 200 mg a day of trans-resveratrol, the active component of resveratrol. Read labels carefully; many won't tell you how much resveratrol is of the trans variety.
Cocoa Flavanols /// Nitric Oxide Booster
Plant chemicals in cocoa known as flavanols help the body synthesize the compound nitric oxide, which is critical for healthy blood flow and healthy blood pressure. Nitric oxide improves platelet function, meaning it makes your blood less sticky. It also makes the lining of the arteries less attractive for white blood cells to attach to and stick around.
Researchers in Germany followed more than 19,000 people for a minimum of 10 years and found that those who ate the highest amount of flavanol-rich dark chocolate had lower blood pressure and a 39 percent lower risk of having a heart attack or stroke compared to those who ate almost no chocolate.11
The Bottom Line
Lowering cholesterol and lowering the risk of heart disease are very far from the same thing.
The former is almost irrelevant. The latter is important, and there's a lot you can do about it that doesn't involve taking prescription drugs for the rest of your life.
The Case for Supplementation
Ask your typical mainstream doctor about nutritional supplements, and the first thing you're likely to hear is this: "There's no good research showing they work." I've heard this refrain time and time again when I discuss nutritional medicine with my more conservative colleagues.
It's not true.
You or your doctor can go online to the National Institute of Medicine's library, 301 Moved Permanently, put into the search box virtually any vitamin or herb you can think of and, depending on what you choose, hundreds to thousands of citations will pop up. So the problem isn't an absence of research.
The problem is twofold. One, the conventional training of medical doctors in this country is highly biased toward pharmaceuticals. From the time they enter med school, doctors are courted by the pharmaceutical companies in myriad ways, some subtle, some not-so-subtle.
Free lunches, symposiums, honorariums, consulting and lecturing contracts, vacations, perky pharmaceutical reps showing up at offices with the latest studies that show their products in a favorable light, and free samples all create a culture in which pharmaceuticals are the first choice in any treatment plan.
Most docs will tell you these practices have no influence on them or what they choose to prescribe, but the research tells a very different story.2,3
The other part of the problem is that much of the research on vitamins flies beneath the radar. Your overworked doctor barely has time to scan the abstracts of the New England Journal of Medicine every month, let alone dig deeply into the hundreds of studies that are published every year on vitamins and nutrients in journals such as the American Journal of Clinical Nutrition.
The vast majority of doctors in this country get no training whatsoever in nutrition, and those who do receive only the most rudimentary and superficial introduction to the subject. Put this together with the built-in medical school bias in favor of patent medicines, and it's easy to see why doctors often fail to think of natural substances as legitimate tools for keeping people healthy.
The New "Medicine" Cabinet
Many supplements are beneficial for heart health. Here's a short guide to the most important ones. If you're not taking these, perhaps you should be.
Omega-3'S /// The Wellness Molecule
Omega-3's are among the most anti-inflammatory substances on the planet and should be part of everyone's heart-healthy nutrition program. Come to think of it, they should probably be part of everyone's nutrition program, period!
Coenzyme Q10 /// Fuel For The Heart
CoEnzyme Q10 is fuel for the heart. It's made in every cell in the body, and your ability to make it diminishes with age. It's virtually unavailable in any meaningful amount from food. It's also depleted by cholesterol-lowering medications, so if you're on one of those you simply must consider supplementing with Coenzyme Q10 on a daily basis!
D-Ribose /// The Energy Maker
D-Ribose is a five-carbon sugar and one of the components of ATP, the energy molecule the body uses to power all activities. Without D-ribose, there is no ATP; without ATP, there is no energy.
L-Carnitine /// The Energy Transport System
Carnitine acts as a kind of shuttle bus, loading up fatty acids and transporting them into tiny structures within the cell called the mitochondria, where they can be burned for energy. Because the heart receives 60 percent of its energy from fat, it's very important that the body has enough L-carnitine to shuttle the fatty acids into the heart's muscle cells.
Magnesium /// The Great Relaxer
Magnesium supplements are a must for those who want to protect their heart. Magnesium lowers blood pressure, helps control blood sugar and relaxes the lining of the blood vessels. And almost all dietary surveys show that Americans aren't getting nearly enough.
When magnesium is depleted, intracellular calcium rises. Magnesium also inhibits platelet aggregation, an important step toward the development of clots.
Calcium channel blockers like Procardia, Adalat, Plendil, and Cardene widen and relax the blood vessels by affecting the muscle cells found in the arterial walls, which is exactly what magnesium does—splendidly, we might add.
Pantethine /// Your Secret Weapon
Pantethine is a metabolically active—and somewhat more expensive—form of Vitamin B-5, or pantothenic acid. The blood tests of patients with dyslypiemia—meaning their blood cholesterol levels are too high—significantly improve with pantethine. And though it's not seen on a blood test, pantethine also reduces the oxidation of LDL.4
No fewer than 28 clinical trials in humans have shown that pantethine produces significant positive changes in triglycerides, LDL cholesterol, and VLDL, along with increases in HDL cholesterol.5 In all of these trials, virtually no adverse effects were noted. The mean dose of pantethine in these studies was 900 milligrams a day, given as 300 mg three times daily. That appears to be the optimal dose, and it's the one I recommend.
Vitamin C /// Powerful Antioxidant
Vitamin C is one of the most powerful antioxidants in the world, and because heart disease is initiated by oxidative damage caused by free radicals, any help you can get in the antioxidant department is a good thing.
And it's not just theoretical: a large 2011 study in the American Heart Journal found that the lower the level of vitamin C in the blood, the higher the risk for heart failure.6 Take 1,000 to 2,000 mg a day.
Curcumin /// The New Superstar Of Supplements
This extract from the Indian spice turmeric has multiple benefits, not the least of which is that it's highly anti-inflammatory. Scientific research has demonstrated its anti-inflammatory, anti-oxidant, anti-thrombotic, and cardiovascular protective effects.7 It also reduces oxidized LDL cholesterol.8
Resveratrol /// Not Just For Anti-Aging
Resveratrol is the ingredient in red wine that's best known for its "anti-aging" activity. It helps protect the arteries, improves their elasticity, inhibits blood clots, and lowers both oxidized LDL and blood pressure.9 Not a bad resume!
It's both a strong anti-oxidant and a strong anti-inflammatory, inhibiting a number of inflammatory enzymes that can contribute to heart disease. It also inhibits the ability of certain molecules to stick to the walls of the artery, where they can take up residence and contribute to inflammation.10
The recommended dose is 200 mg a day of trans-resveratrol, the active component of resveratrol. Read labels carefully; many won't tell you how much resveratrol is of the trans variety.
Cocoa Flavanols /// Nitric Oxide Booster
Plant chemicals in cocoa known as flavanols help the body synthesize the compound nitric oxide, which is critical for healthy blood flow and healthy blood pressure. Nitric oxide improves platelet function, meaning it makes your blood less sticky. It also makes the lining of the arteries less attractive for white blood cells to attach to and stick around.
Researchers in Germany followed more than 19,000 people for a minimum of 10 years and found that those who ate the highest amount of flavanol-rich dark chocolate had lower blood pressure and a 39 percent lower risk of having a heart attack or stroke compared to those who ate almost no chocolate.11
The Bottom Line
Lowering cholesterol and lowering the risk of heart disease are very far from the same thing.
The former is almost irrelevant. The latter is important, and there's a lot you can do about it that doesn't involve taking prescription drugs for the rest of your life.
