<center>NFL Point Spreads For Week 1 - Week One NFL Football Point Spread - NFL Spreads 9/4 - 9/8, 2014
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| Date & Time | Favorite | Spread | Underdog |
| 9/4 8:35 ET | At Seattle | -5.5 | Green Bay |
| 9/7 1:00 ET | New Orleans | -3 | At Atlanta |
| 9/7 1:00 ET | At St. Louis | -4 | Minnesota |
| 9/7 1:00 ET | At Pittsburgh | -6.5 | Cleveland |
| 9/7 1:00 ET | At Philadelphia | -10.5 | Jacksonville |
| 9/7 1:00 ET | At NY Jets | -5 | Oakland |
| 9/7 1:00 ET | At Baltimore | -2.5 | Cincinnati |
| 9/7 1:00 ET | At Chicago | -6.5 | Buffalo |
| 9/7 1:00 ET | At Houston | -2.5 | Washington |
| 9/7 1:00 ET | At Kansas City | -4.5 | Tennessee |
| 9/7 1:00 ET | New England | -4.5 | At Miami |
| 9/7 4:25 ET | At Tampa Bay | -1 | Carolina |
| 9/7 4:25 ET | San Francisco | -6 | At Dallas |
| 9/7 8:30 ET | At Denver | -7 | Indianapolis |
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| 9/8 7:10 ET | At Detroit | -4.5 | NY Giants |
| 9/8 10:25 ET | At Arizona | -3 | San Diego |
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