hGH Human Growth Hormone - What Is hGH?
Human Growth Hormone -
Human Growth Hormone (somatropin) also referred to as rHGH, hGH, or GH) is a protein produced in the pituitary gland that stimulates the liver to produce IGF-1 along with other insulin growth factors, which stimulate growth of bone and muscle. HGH is also instrumental in cell regeneration, immune system support, cardio-vascular health, organ and tissue healing and repair. As we grow into adulthood, hGH is responsible for keeping our muscles from wasting away, supports our healthy immune system responses and regulates aspects of our metabolic functions, dealing with increased fat metabolism and healthy body composition later in life; in additon hGH maintains and repairs our skin and other tissues.
Levels of hGH in our bodies usually peak while we are in adolocence, then begin to taper off during our early 30s; thus by the time we reach or 60s our levels of hGH secretion being produced daily is as low as 10% of what it was during our youth; thus producing the age markers showing decreased hGH levels listed below:
· Increase in fat · Decrease in muscle and lean body structures · Decreased skin texture resulting in a less youthful appearance · Decreased bone density, onset of osteoporosis · Decreased brain function, loss of intellect with aging · Decreased sex drive · Decrease in overall physical and mental well being · Increase in sleep disorders, lower quality of sleep · Depression and fatigue
HGH Therapy can reverse or improve these symptoms in the majority of patients that engage in this therapy. This is why you will often hear references with respect to HGH as “The Fountain of Youth” It can present a better quality of life for those of us aging, as well as provide many other great benefits. HGH (and IGF-1 which is a result of its use) is the only substance that can actually initiate hyperplasia, which equates to new muscle cells. While use of anabolic steroids can cause hypertrophy (the enlargement of existing muscle cells), steroids do not offer the ability to recruit and mature more muscle cells; HGH can. HGH also increases protein synthesis, which can be responsible for hypertrophy. HGH also strengthens and heals connective tissues, cartilage, and tendons. These uses are what make it so attractive to athletes in all sports.
Human growth hormone (hGH - somatropin/somatotropin is one of the most abundant hormones secreted by the anterior lobe of the pituitary gland or otherwise known as the Hypophysis. Once gh or growth hormone is released by the pituitary gland it is quickly taken in by the liver and converted into growth factors, the most important growth factor is the one called IGF-1.
These growth factors are the messengers that carry the signals or messages to the cells of the body. This communication regulates the growth of cells, telling them when to live and when to die. Cellular reproduction slows, unless the cells are prompted by the growth factors of hGH and IFG-1. During the growth and development stage of life, human growth hormone is responsible for proper growth and development of our muscles and bones. However once adulthood is reached hGH slows production which causes our bodies to change as we age, increase in belly fat, sagging skin, increased immune disorders, and that is what we strive to curver; the process of our bodies aging as we grow older. The importance of hGH is that it effects almost every cell of our body and helps to keep the cells and systems healthy.
Healthy levels of hGH account for things such as good muscle/fat ratio, a high libido, good sexual function, energy and endurance, good muscle tone, menopause, improved sleep, increased bone-density, regulates our blood pressure and better overall skin. As we age the function of the pituitary gland releases lower and lower amounts of HGH into the bloodstream for the body to use. Therefore we inject bio-synthetic somatropin which is an exact replica of what our bodies produce, back into the endocrine system to slow and reverse these aging symptoms.
How Does hGH work Systemically?
HGH is short lived, but during its short half-hour activity per burst from the pituitary gland; it exerts itself through direct and indirect effects. Its direct effects are the result of the HGH binding its receptor on target cells (as the chart above). Fat cells (adipocytes) as well as myocytes (muscle cells) have HGH receptors. On fat cells, HGH stimulates them to break down triglyceride and suppresses the fat cells ability to uptake circulating lipids.
Its indirect effects are in the process we described in the section above. When HGH travels to the liver, the result in its pass through the liver is the secretion of IGF-1. When this IGF-1 is secreted, it stimulates proliferation of chondrocytes (cartilage cells), which result in bone growth. It also plays a part in stimulating both the proliferation and differentiation of myoblasts (the precursor to skeletal muscle fibers). IGF-1 also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
HGH stimulates protein anabolism in many tissues. This reflects increased protein synthesis, decreased oxidation of proteins, and increased amino acid uptake. As mentioned above, HGH enhances fat utilization by stimulating triglyceride breakdown and oxidation in fat cells (adipocytes).
HGH can affect the function of other hormones. HGH can suppress the abilities of insulin to stimulate the uptake of glucose in tissues and enhance glucose synthesis in the liver, though administering hGH actually stimulates insulin secretion and can create a state of hyperinsulinemia. This combination can lead to decreased insulin sensitivity, which in turn can lead to hyperglycemia. HGH can also have a slight inhibitory effect on the thyroid, though this varies greatly from individual to individual
hGH - Structure
The major isoform of the human growth hormone is a protein of 191 amino acids and a molecular weight of 22,124 daltons. The structure includes four helices necessary for functional interaction with the GH receptor. It appears that, in structure, GH is evolutionarily homologous to prolactin and chorionic somatomammotropin. Despite marked structural similarities between growth hormone from different species, only human and primate growth hormones have significant effects in humans.
Several molecular isoforms of GH exist in the pituitary gland and are released to blood. In particular, a variant of approximately 20 kDa originated by an alternative splicing is present in a rather constant 1:9 ratio,while recently an additional variant of ~ 23-24 kDa has also been reported in post-exercise states at higher proportions.This variant has not been identified, but it has been suggested to coincide with a 22 kDa glycosilated variant of 23 kDa identified in the pituitary gland.Furthermore, these variants circulate partially bound to a protein (growth hormone-binding protein, GHBP), which is the truncated part of the growth hormone receptor, and an acid-labile subunit (ALS).
Non-medical use of hGH in Athletic Enhancement
Athletes in many sports have used human growth hormone in order to attempt to enhance their athletic performance. Some recent studies have not been able to support claims that human growth hormone can improve the athletic performance of professional male athletes. However a very recent scientific medical journal written here states otherwise. Athletic societies have banned the use of rhGH and will issue sanctions against athletes who are caught using it (thus our questioning; "If it doesn't improve athletic ability, why is it prohibited?"
History of use and manufacture of GH as a drug
The identification, purification and later synthesis of growth hormone is associated with Choh Hao Li. Genentech pioneered the first use of recombinant human growth hormone for human therapy in 1981.
Prior to its production by recombinant DNA technology, growth hormone used to treat deficiencies was extracted from the pituitary glands of cadavers. Attempts to create a wholly synthetic HGH failed. Limited supplies of HGH resulted in the restriction of HGH therapy to the treatment of idiopathic short stature.Furthermore, growth hormone from other primates was found to be inactive in humans.
In 1985, unusual cases of Creutzfeldt-Jacob disease were found in individuals that had received cadaver-derived HGH ten to fifteen years previously. Based on the assumption that infectious prions causing the disease were transferred along with the cadaver-derived HGH, cadaver-derived HGH was removed from the market. In 1985, biosynthetic human growth hormone replaced pituitary-derived human growth hormone for therapeutic use in the U.S. and elsewhere.
As of 2005, recombinant growth hormones available in the United States (and their manufacturers) included Nutropin (Genentech), Humatrope (Lilly), Genotropin (Pfizer), Norditropin (Novo), and Saizen (Merck Serono). In 2006, the U.S. Food and Drug Administration (FDA) approved a version of rHGH called Omnitrope (Sandoz). A sustained-release form of growth hormone, Nutropin Depot (Genentech and Alkermes) was approved by the FDA in 1999, allowing for fewer injections (every 2 or 4 weeks instead of daily); however, the product was discontinued by Genentech/Alkermes in 2004 for financial reasons (Nutropin Depot required significantly more resources to produce than the rest of the Nutropin line.
Patient Education - English
What is the most important information I should know about somatropin?
Before you receive somatropin, tell your doctor about all your past and present medical conditions, especially allergies, trauma, surgery, diabetes, cancer, breathing problems, liver or kidney disease, scoliosis, high blood pressure, pancreas disorder, underactive thyroid, or a brain tumor.
Also tell your doctor about all other medications you use, especially steroids or diabetes medications. Your dosages of these medicines may need to be changed when you start using somatropin. Do not stop using a steroid suddenly or change any of your medication doses without your doctor's advice. If you have Prader-Willi syndrome and are using somatropin, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring.
Call your doctor at once if you have sudden and severe pain or tenderness in your upper stomach, with nausea, vomiting, sweating, fever, fast heartbeat, and yellowing of the skin or eyes. You should also call your doctor promptly if you have vision changes and sudden, severe pain behind your eyes.
What is somatropin?
Somatropin is a form of human growth hormone. Human growth hormone is important in the body for the growth of bones and muscles. Somatropin is used to treat growth failure in children and adults who lack natural growth hormone, and in those with chronic kidney failure, Noonan syndrome, Turner syndrome, short stature at birth with no catch-up growth, and other causes. Somatropin is also used to prevent severe weight loss in people with AIDS, or to treat short bowel syndrome. Somatropin may also be used for other purposes not listed in this medication guide.
What should I discuss with my healthcare provider before using somatropin?
Before you receive somatropin, tell your doctor if you have ever had an allergic reaction to a growth hormone medicine, or to drug preservatives such as benzyl alcohol, metacresol or glycerin.
You should not use this medication if you are allergic to somatropin, or if you have:
diabetic retinopathy (a serious eye condition caused by diabetes) or cancer / or Prader-Willi syndrome and are also overweight or have sleep apnea or severe respiratory (lung) problems.
You should also not use somatropin if you have a serious medical condition after having:
open heart surgery or stomach surgery / trauma or other medical emergency / breathing problems (such as lung failure). If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication.
Before using somatropin, tell your doctor if you have:
liver disease;
kidney disease (or if you are on dialysis);
diabetes;
scoliosis;
high blood pressure (hypertension);
a pancreas disorder (especially in children);
a history of cancer;
carpal tunnel syndrome;
underactive thyroid; or
a brain tumor or lesion.
FDA pregnancy category B. Some brands of somatropin are not expected to harm an unborn baby, including Genotropin, Omnitrope, Saizen, Serostim,Zorbtive and other approved 191 aa versions of rhGH.
FDA pregnancy category C. It is not known whether certain other brands of somatropin will harm an unborn baby, including Humatrope, Norditropin, Nutropihn, and Tev-tropin. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether somatropin passes into breast milk or if it could harm a nursing baby. Do not use somatropin without telling your doctor if you are breast-feeding a baby.
How should I use somatropin?
Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your dose and brand of somatropin, and how often you give it will depend on what you are being treated for. Follow the directions on your prescription label.
Somatropin is injected into a muscle or under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.
Use a different place on your body each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row. Do not inject this medicine into skin or muscle that is red, sore, infected, or injured.
Do not shake the medication bottle or you may ruin the medicine. When mixing somatropin with a diluent (liquid), use a gentle swirling motion. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.
Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.
To be sure this medication is helping your condition and not causing harm, your blood and growth progress will need to be tested on a regular basis. Your eyes may also need to be checked. Visit your doctor regularly. If you are being treated for short bowel syndrome, follow the diet plan created for you by your doctor or nutrition counselor to help control your condition. Somatropin is not a cure for short bowel syndrome.
If you use a form of somatropin that comes in a cartridge for use with an injection pen, use only the pen injection system provided with the somatropin brand you use.
How you store this medicine will depend on what brand you are using and what diluent you are mixing somatropin with. After mixing somatropin, you may need to use it right away or you may be able to store it for later use. Read and carefully follow the instructions provided with your medicine about proper storage of somatropin before and after it has been mixed. Ask your pharmacist if you have any questions about proper storage of your medication.
Throw away any somatropin left over after the expiration date on the label has passed (even though scientific research has confirmed rhGH in a lypholized powder state can last 5 years if refrigerated)
What happens if I miss a dose?
Use the missed dose as soon as you remember or Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose. Call your doctor if you miss more than 3 doses in a row.
What happens if I overdose?
Seek emergency medical attention and call our office and a Poison Help. Overdose can cause tremors or shaking, cold sweats, increased hunger, headache, drowsiness, weakness, dizziness, fast heartbeat, and nausea. Long-term overdose may cause excessive growth.
What should I avoid while using somatropin?
If you use Zorbtive to treat short bowel syndrome, avoid drinking fruit juices or soda beverages. Follow the instructions of your doctor or nutrition counselor about what types of liquids you should drink while using Zorbtive. Avoid drinking alcohol if you have short bowel syndrome. Alcohol can irritate your stomach and could make your condition worse.
What are the possible side effects of somatropin?
If you have Prader-Willi syndrome, call your doctor promptly if you develop signs of lung or breathing problems such as shortness of breath, coughing, or new or increased snoring. Rare cases of serious breathing problems have occurred in patients with Prader-Willi syndrome who use somatropin. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
sudden and severe pain or tenderness in your upper stomach;
nausea, vomiting, sweating, fever, fast heartbeat, yellowing of the skin or eyes;
increased thirst and urination;
sudden and severe pain behind your eyes, vision changes;
swelling in your head, face, hands, or feet; or
numbness or tingling in your wrist, hand, or fingers.
Less serious side effects may include:
headache;
redness, soreness, swelling, skin rash, itching, pain, or bruising where the medicine was injected;
breast swelling;
joint pain, swelling, or stiffness; or
mild nausea, stomach pain, gas.
What other drugs will affect somatropin?
Before using somatropin, tell your doctor if you use insulin or take oral (by mouth) medicine to treat diabetes. Somatropin may affect blood sugar levels and you may need to adjust your dose of the diabetes medication. Do not change the dose of your diabetes medication without your doctor's advice.
Tell your doctor if you use any type of steroid medicine such as cortisone, dexamethasone, methylprednisolone, prednisone, and others. Steroids can make somatropin less effective and your doses may need to be adjusted. Do not stop using a steroid suddenly. Follow your doctor's instructions.
Tell your doctor about all other medications you use, especially cyclosporine (Gengraf, Neoral, Sandimmune), seizure medication, birth control pills, anabolic steroids, or hormone replacement medications for men or women.
This list is not complete and other drugs may interact with somatropin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Therefore we have a hormone that can assist with maintenance and the healing of most of our body's systems, it can create new cartilage, increase bone density, increase muscle cells, assist with protein uptake, decrease oxidation of proteins, and can accelerate the rate at which fat in our bodies is utilized. This is why excitement follows hGH & IGF-1; You may ask "How do I utilize this hormone to my advantage" contact us to dsicuss our exogenous hGH therapy by going to the "Get Started Link" and sign up for brief phone consult. You'll be glad you took this first step, To A Whole New You.
* Human Growth Hormone (hGH) is only available in injectable form. hGH is not available in tablet, capsule, cream or spray form. hGH can only be applied via syringe injected sub-cutaneously.
Clínica Médica
Yacht Club - Marina Del Rey Suite 32-A
Col. Marina Vallarta, Pto. Vallarta
Jal., Mexico 48354
Phone: 800-798.4598
Email: Hgh Medical Clinic
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