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View Full Version : Formoterol - First Report? Logging.. Formoterol Review



Area 1255
10-05-2014, 07:19 AM
So I got my hands on the 12-hour long acting beta-agonist inhaler thingy known as formoterol..which in some studies has been shown to decrease myostatin and have a stronger anabolic effect than both clenbuterol and albuterol. It comes with pierceable capsules that you load into an inhaler, but the best way I've found is to inhale one 12mcg capsule , and orally take a half of another - 6 mcg in some water or hold it under your tongue, but don't put the capsule in your mouth, it's hard to break down. just open it up and hold the powder under neath your tongue.
Formoterol treatment downregulates the myostatin ... [Oncol Lett. 2012] - PubMed - NCBI (http://www.ncbi.nlm.nih.gov/pubmed/22740878)


Formoterol treatment downregulates the myostatin system in skeletal muscle of cachectic tumour-bearing rats.

Busquets S (http://www.ncbi.nlm.nih.gov/pubmed?term=Busquets%20S%5BAuthor%5D&cauthor=true&cauthor_uid=22740878)1, Toledo M (http://www.ncbi.nlm.nih.gov/pubmed?term=Toledo%20M%5BAuthor%5D&cauthor=true&cauthor_uid=22740878), Marmonti E (http://www.ncbi.nlm.nih.gov/pubmed?term=Marmonti%20E%5BAuthor%5D&cauthor=true&cauthor_uid=22740878), Orpí M (http://www.ncbi.nlm.nih.gov/pubmed?term=Orp%C3%AD%20M%5BAuthor%5D&cauthor=true&cauthor_uid=22740878), Capdevila E (http://www.ncbi.nlm.nih.gov/pubmed?term=Capdevila%20E%5BAuthor%5D&cauthor=true&cauthor_uid=22740878), Betancourt A (http://www.ncbi.nlm.nih.gov/pubmed?term=Betancourt%20A%5BAuthor%5D&cauthor=true&cauthor_uid=22740878), López-Soriano FJ (http://www.ncbi.nlm.nih.gov/pubmed?term=L%C3%B3pez-Soriano%20FJ%5BAuthor%5D&cauthor=true&cauthor_uid=22740878), Argilés JM (http://www.ncbi.nlm.nih.gov/pubmed?term=Argil%C3%A9s%20JM%5BAuthor%5D&cauthor=true&cauthor_uid=22740878).
Author information (http://www.ncbi.nlm.nih.gov/pubmed/22740878#)



Abstract


Cachexia is a common systemic manifestation. Additionally, myostatin is known to be a negative regulator of skeletal muscle development. The present study aimed to investigate whether formoterol down-regulates the myostatin system in skeletal muscle of tumour-bearing rats. Real-time PCR and Western blotting were used for the analysis. Results showed that rats bearing the Yoshida AH-130 ascites hepatoma, a cachexia-inducing tumour, exhibited marked muscle wasting that affected the mass of the muscles studied. The cachectic animals exhibited a significant increase in the mRNA levels of the myostatin receptor (ActIIB) in gastrocnemius muscles. Notably, the expression of the various forms of follistatin, a protein with the opposite effects to those of myostatin, was significantly reduced as a result of the implantation of the tumour. When the animals were treated with formoterol, a β-agonist with anti-cachectic potential, increases in skeletal muscle weights were observed. The β-agonist significantly increased levels of various follistatin isoforms and significantly decreased the expression levels of the myostatin receptor. In addition, formoterol treatment resulted in a significant decrease of the myostatin protein content of the gastrocnemius muscle. In conclusion, the results presented indicate that certain anabolic actions of formoterol on the skeletal muscle of cachectic animals may be mediated via the myostatin system.

http://aups.org.au/Proceedings/43/41P/41P.pdf

Neuromuscul Disord. (http://www.ncbi.nlm.nih.gov/pubmed/17134898#) 2007 Jan;17(1):47-55. Epub 2006 Nov 28.
Low dose formoterol administration improves muscle function in dystrophic mdx mice without increasing fatigue.

Harcourt LJ (http://www.ncbi.nlm.nih.gov/pubmed?term=Harcourt%20LJ%5BAuthor%5D&cauthor=true&cauthor_uid=17134898)1, Schertzer JD (http://www.ncbi.nlm.nih.gov/pubmed?term=Schertzer%20JD%5BAuthor%5D&cauthor=true&cauthor_uid=17134898), Ryall JG (http://www.ncbi.nlm.nih.gov/pubmed?term=Ryall%20JG%5BAuthor%5D&cauthor=true&cauthor_uid=17134898), Lynch GS (http://www.ncbi.nlm.nih.gov/pubmed?term=Lynch%20GS%5BAuthor%5D&cauthor=true&cauthor_uid=17134898).
Author information (http://www.ncbi.nlm.nih.gov/pubmed/17134898#)



Abstract

The beta(2)-adrenoceptor agonist (beta(2)-agonist), formoterol, has been shown to cause muscle hypertrophy in rats even when administered at the micromolar dose of 25 micro g/kg/day. We investigated whether a similar low dose of formoterol could improve muscle function in the dystrophic mdx mouse. Ten-week-old male mdx and wild-type (C57BL/10) mice were administered formoterol (25 micro g/kg/day, i.p.) for 4 weeks. Formoterol treatment increased extensor digitorum longus (EDL) and soleus muscle mass, increased median muscle fibre size in diaphragm, EDL, and soleus muscles, and increased maximum force producing capacity in skeletal muscles of both wild-type and mdx mice. In contrast to other studies where beta(2)-agonists have been administered to mice and rats, generally at higher doses, low dose formoterol treatment did not increase the fatiguability of EDL, soleus or diaphragm muscles. Although others have found formoterol can decrease ubiquitin mRNA and proteasome activity when administered to tumour bearing rats at high doses (2mg/kg/day), in the present study low dose formoterol treatment did not alter ubiquitin or the E1 and E3 ubiquitin ligases in diaphragm muscles of wild-type or mdx mice, but it did reduce the level of ubiquitinated proteins in diaphragm of wild-type mice. The findings indicate that formoterol has considerably more powerful anabolic effects on skeletal muscle than older generation beta(2)-agonists (like clenbuterol and albuterol), and has considerable therapeutic potential for muscular dystrophies and other neuromuscular disorders where muscle wasting is indicated.






Now I know some they have been skeptical, but I think this report will help lay out everything quite nicely.

Things I noticed so far...


I've been using it straight for a week.


Only need to dose once a morning by the way , 12 hour effect is clean, with a little OCD anxiety....go on.



Absolutely ridiculous and unprovoked motivation to work out, it internalizes the energy to such an extent that you just have to work out.
Eliminates almost all soreness it seems, recovery times are definitely shortened.
Crazy endorphin rush, usually I add in yohimbine with albuterol, but with form there is no need for either, but I do stack it with caffeine.
Seems to be increasing my strength quite a bit. The amount of reps on the bench and with calisthenics is greater on each set.
Very impressed so far... will continue logging.



I can see some serious cutting benefits and some mass gain down the road.

guardianactual
10-05-2014, 08:33 AM
In for ghe ride!

Area 1255
10-08-2014, 10:21 PM
10-8-2014

-Took off yesterday as a rest day, but also I believe as with the studies that perhaps I should cycle 5 day on , 1 or two days off...so as to prevent/minimize beta-adrenergic downregulation.
-I honestly see this as stronger than clen, the effects are very pleasant...and only very mild tachycardia...not enough to be annoying or concerning.
-Definitely is enhancing the pump and vascularity....
-No trouble getting to sleep but I would advise dosing for a morning or afternoon workout because as said before, the 12 hour half life is no joke.

Presser
10-09-2014, 10:06 AM
10-8-2014

-Took off yesterday as a rest day, but also I believe as with the studies that perhaps I should cycle 5 day on , 1 or two days off...so as to prevent/minimize beta-adrenergic downregulation.
-I honestly see this as stronger than clen, the effects are very pleasant...and only very mild tachycardia...not enough to be annoying or concerning.
-Definitely is enhancing the pump and vascularity....
-No trouble getting to sleep but I would advise dosing for a morning or afternoon workout because as said before, the 12 hour half life is no joke.

Only a bodybuilder would make a statement like that lmao, ""ahhh no big deal, just some mild Tachycardia"" lol,

Area 1255
10-09-2014, 10:48 AM
Only a bodybuilder would make a statement like that lmao, ""ahhh no big deal, just some mild Tachycardia"" lol,
Lmao.

burntwookie
10-11-2014, 08:19 PM
Joined this site just to follow this log.

I've been interested in this stuff since June, and read the article on science daily. I wanted to try it, but all I could find were the rotacaps (now sold out at my sources) and didn't know how to dose them.

Procaterol is also part of the 2nd gen b2 agonists.

Looking at this list, it's the strongest:

http://i.imgur.com/sRFmokM.jpg (http://imgur.com/sRFmokM)

Presser
10-12-2014, 08:20 AM
welcome to MC burntwookie

burntwookie
10-12-2014, 10:22 AM
welcome to MC burntwookie

Thank you.

OP, what were your starting measurements?

Area 1255
10-13-2014, 12:06 PM
Thank you.

OP, what were your starting measurements?
Measurements as in dose?
12 mcg inhaled, then 6 mcg diluted in water... i have the capsules plus the inhaler thingy.
It's brand name is "foradil"

- - - Updated - - -

10-13-2014

-Noticing a notable sense of immense focus and mental clarity, almost kinda getting a parallel to masteron in some ways...
-Omega pursuit of goals ; both financial and physical.
-Definite endorphin rush...
-Vascularity is coming out quite nicely, and I am noticing a little toning already and veins coming out massively.
-Especially during curls, pumps are amazing.
-I'm going to try it with arginine nitrate tomorrow and see what happens!

Area 1255
10-15-2014, 04:56 PM
10-15-2014

Ok so the synergy with arginine nitrate went very well! Although I feel like I needed a little more caffeine to balance it out with that, but long story short, this stuff definitely keeps you going all day. I still sip coffee throughout, mainly because of the synergism, but I am finding that I can work fine consuming altogether less coffee. So this is no 3 hour, four hour shit like albuterol, this is something that really lasts the whole day, about 11.5 hours to be exact.
As long as you don't dose it much further than the afternoon, you should still get to sleep fine, in fact, I am still getting to sleep fine altogether, especially after a hard workout day!

Core body workouts, farmer's walk etc... = sleep like a baby at night.

Also should mention that the general consensus is that over time, beta adrenergic agonists also downregulate histamine h1 receptors, so this might be a mechanism in actually helping sleep similar to over the counter sleep aids...in fact, I tested this theory a couple times now, and I don't usually use benadryl to get to sleep, I just wanted to see if using a less dose would hit me harder because of technically significant or theoretical h1 downregulation (aka less histamine h1 receptors) - and cha-ching, I used 10 miligrams of ben and it hit me like 25!

Mind you, this is a couple weeks in after starting the form....

So fellas, keep aware if you attempt this regimen, that the science definitely holds true, you will have increased sensitivity to sleep aids of the antihistamine type while using long acting beta agonists, at least, this is what I have found.

Also , the other benefit due to histamine h1 downregulation should be enhanced vasodilation in general, and this might not happen as much with albuterol, or maybe not even clen....but with this 12 hour shit Is definitely stronger, slightly stronger than clen tbh...


I don't recommend trying to afford this without insurance, it will be hella expensive, it was 45 bucks for a co pay but my second insurance wouldn't push it through. Keep in mind this is legal obtaining of this product, without any insurance this shit would be well over 100 bucks.

Although I've heard other brands maybe around 80 if you get it through the right place.

Area 1255
10-16-2014, 07:12 PM
10-16-2014

Ok fellas, this is def no joke, I stopped a few of my other sups , well to be specific, I ran out of my multi the last couple days and will pick a new one up tomorrow, so before anyone sais that it's because of a special multi or some distorted placebo effect, that's there now. Also no caffeine today and still got a huge buzz from this product including energy to keep going way through and then extra sets til failure. Today was mainly calisthenics but the point remains the same.

So what that means is that form solo is completely competent on it's own....and although I'm not gonna go without a multi for long, mainly because using stims tends to deplete b vitamins and magnesium..but I'm also out of mag which i will be getting tomorrow.

I think that things might be about the same the only difference with caffeine is it almost stretches the feeling of the form to borderline or full euphoria...but an energizing kind.

This is sensible though.

Area 1255
10-18-2014, 09:32 AM
10-18-2014

One sentence describes this product as the days go on, though I did up to 19mcg ....12 inhaled and 7 measured out.
Sentence : Relentless pursuit of goals, pushing myself even harder than ever before is internalized to an extent unprecedented. This is the ultimate preworkout tool.
Goes further beyond assault in that direction, and a little further than clen.

Area 1255
10-22-2014, 02:21 PM
(!) 10-22-2014 (!)

So I am finding that I am indeed getting a little sensitivity to this as I didn't take the two / one rest days and it is evident because I didn't get much of the effects / benefits today or yesterday despite continuing, and also I used less of a dose (8mcg,micrograms,ingested) and yet am getting more side-effects ; anxiety, which I never get, and some tingling as well as tachycardia...this time not so comfortable. So I reckon that this absolutely, like clen, should be cycled...

Overall actually feel a little lethargic today..despite the same amount of caffeine.
Definitely cycle fellas!

Also a buddy of mine tried some and he got crazy sweats and cold hands at only 7mcg ingested...just throwing it out there that everyone has different tolerance/sensitivity to stims!

Just because I can handle a little more (perhaps) than the average stim user doesn't mean that 4mcg won't cause anxiety / tachycardia for some people....

Something to keep in mind...

It seems with form there's a very clear bridge, but yet no so clear..as to what to cross (dose wise) and it's a very fine line indeed.
Specific to the individual.

Area 1255
10-29-2014, 07:56 AM
10-29-2014

Definitely finding that the two day off is necessary..of course, shoulda expected that.
It's been a productive week, although I took an extra day off training due to an unexpected family emergency.
My thoughts on this largely remain the same, and I've definitely got a slight increase in weight and some arm increase and yet have solidified, putting this in light terms; it's anabolic effects simply have to be reminiscent of clen but yet the specific effects, even drying to an extent, not just hardening...on the level of Inhibit-E...
When you combine it with more than 150 mg of caffeine, you will be pissing a few more times than you had planned..at least this is my experience and some other testers I've talked to.
Also continually seeing strength increases, especially on the days I take it with arginine nitrate or cellucor's NO3 - both the pumps and strength is unreal...and they have generally only improved!
Every set now I am pumping out every reps, very impressive!

Any questions feel free to post here, or PM me!

Area 1255
11-04-2014, 09:48 PM
11-4-2014
Took a few days off because of suspected sensitivity / tolerance....
The last couple days have been very productive though and the full fury of form returned with a vengeance!
Definitely seeing a great deal of continued chiseling and definition - even though I'm always pretty lean. (9-10%)
Strength is definitely way up on this, though not so much on the sensitivity days.
Again, cycle.

Interestingly, the tachycardia has not been noticeable at all..in fact, it's been pretty much absent...
I'm guessing the loading phase or initiation was probably my body getting used to the stronger compound, and that I used two different delivery methods.

Area 1255
12-12-2014, 08:10 PM
12-12-2014

Sorry for the lack of updates, my Internet was down for the last week and before that I was taking a trip to see my distant cousins for a few weeks....now that I am back, of the last few days....

I will make some conclusions and summarize my experience with this.

1 week time elapsed if you consider all of the above, but I definitely lean bulked a bit while on this.
Word of a d v i c e , be careful eating too much spicy food while on form, as it seems to amplify the effects of it - both positive and negative...the tachycardia dissipates as you keep using it, but so do the benefits, so you must cycle it similar to clen!

Although I used multiple methods of absorption, inhaling + oral....(powder in water) - the last couple weeks I used it I just suspended an entire capsules worth in water, I didn't attempt transdermalizing it or snorting it, nor did I try injections.....my feeling is that injecting form would be much riskier, and you would presumably have to add bacteriostatic water, which I do not have in stock right now...but I plan on getting more soon .

One other final deal, that I didn't find out til later on, in the last week of use I attempted the combo (on the last two days) of form plus 5 mg Cialis and arginine nitrate as an experiment....and I experienced a 6 hour stiffy that was not painful or too much bother, luckily , didn't go anywhere on these days.


I will have another log coming up soon too.

Area 1255
10-02-2015, 06:53 PM
Btw ladies and gents got extra form if ya need any shoot me a PM I'll give you a bargain price! month supply or more!

Presser
12-04-2015, 09:52 PM
How about bringing more of those articles you write over here! Just got done reading ur blog and links to studies and abstracts etc.. Interesting though I don't think I'd use the formoterol but interesting none the less

Mountain_Man
12-06-2015, 07:19 AM
Very interested in this ESP for the wife thanks for all the great information freind

Area 1255
12-16-2015, 05:54 PM
How about bringing more of those articles you write over here! Just got done reading ur blog and links to studies and abstracts etc.. Interesting though I don't think I'd use the formoterol but interesting none the less

Will do!
Glad to be of help.
I think with a little work - we can plump up the appeal here even more...I have some nice share's planned. :)

ThomasCela
06-09-2016, 05:21 PM
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Dean Destructo
06-09-2016, 05:46 PM
very interesting. Good stuff

Area 1255
06-09-2016, 06:56 PM
very interesting. Good stuff
Indeed it is, also we may have a new member signing up soon to report their experience with form. :)

Presser
06-10-2016, 07:40 AM
good to see some of ur articles revisited

thudgens96
06-10-2016, 07:42 AM
I tried formoterol years ago but had no idea how to use

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