Aveed (Test U in castor oil)

Cowboy3

New member
Aveed is a relatively new drug in regard to it recently being approved. Its testosterone undecanoate in castor oil to extend the active life. It's 250mg/ml and contains test U, castor oil, and BB. It does not have BA as it is only supplied in 3ml single dose vials. They will not give it to you at the pharmacy, rather they give you shots at the docs office. One starting dose, one 4 weeks later then one every 10 weeks. They say steady state levels are achieved after the third shot and after the first two it one 3cc shot every 10 weeks. The breakdown given in the literature is: "Each single use vial contains 3 mL of 250mg,mL testosterone undecanoate solution in a mixture of 1500mg of benzyl benzoate and 885 mg of refined castor oil." By my calculation this comes out to 1.3cc BB, .9cc castor oil, .8cc test u. This comes out to roughly 43% BB which is well above the standard 20% used by most homebrewers.

Powderguy's recent post about BB and BA says a concentration this high will lead to negative effects. I'm looking to make this shortly but with the addition of BA because I will be using multi-dose vials instead of singles. My question to you all is have you ever tried anything like this and how did it work. I would assume that if it has been approved by the FDA the recipe should work and be safe. I'd love to hear from powderguy on this and anyone who has experience brewing with castor oil or high BB concentrations.
 
Thanks for bring this up. Well here goes a new and confusing topic that I didn't want to bring up because unrefined castor oil can and will kill.
I was afraid to post it in case some used it improperly and found themselves in the ER or worse.
There are scholarly articles on its use and proved well worth it in human trails. This is one of those articles I have in my "Journal of Pharmaceutical Sciences 2014"

"Steroid hormones may be administered parenterally in high concentrations as oil solutions. In this form they exhibit a prolonged action and reduce the number of injections required. To accommodate the demand for increasingly greater concentrations of hormones in solution, castor oil in combination with other suitable oilmiscible solvents, has been found to fulfill a need. The development of several formulations together with the results of animal testing, as well as clinical trials in humans, attest to the acceptability of this oil for the purposes intended. Castor oil can be refined to almost 100 percent sterility however, some human testing has found external testing is required before administration due to severe reactions that have proved fatal in clinical trails. Carrier oils and solvents are nothing new to the industry thus proving carriers can be of any slightly viscus material that has an organic property. Synthetic carriers almost always cause severe scarring on veins and tissue in the surrounding injection area of patients. The theory surrounding Castor Oil is highly refined, super-heated and treated as a solvent is added usually containing a natural solvent such as Benzyl benzoate or other preservative. the addition of an alcohol base solvent breaks castor oil down into a hydrogen based poisonous substance, therefore alcohol based preservatives should never be used. New drugs containing a Castor Oil base are passing initial FDA approved trail runs. This should not be confused with actual approval and fatalities have occurred using a Castor Oil base." End of quote

CASTOR OIL-Is normally safe and used internally as a laxative due to its strong stimulant properties. its usually safe if the source is well known and all ingredients stated on the product and backed by inspection.

WARNING: Castor oil is considered safe in proper doses for conventional uses as a laxative. However, side effects can include abdominal pain or cramping, colic, nausea, vomiting, and diarrhea. Long-term use of castor oil can lead to fluid and electrolyte loss, scarring and death.
Women who are pregnant or breast-feeding should not use castor oil, nor should people with intestinal blockage, acute inflammatory intestinal disease, appendicitis, or abdominal pain. Medicines that are dissolved in or based on castor oil compounds can cause severe allergic reactions, bleeding at the site of administration and death.
Castor beans are extremely poisonous and can kill people or animals if chewed or swallowed or any part is not fully extracted in oil. Also, handling the seeds can lead to allergic reactions and death.

So with that said, you determine if its something you would use.
 
Thanks Powderguy for chiming in, I thought you would have some good info. Is there an alternative to BA to use as a bacteriostat you'd recommend?

What are your thoughts on the high concentration of BB?

Anybody who's brewed with refined castor oil what type of filter membrane did you use?
 
I personally have never brewed with it. I have smelled heated castor oil and it smells putrid.
Most single dosed vials are vacuum sterile air sealed and don't require the preservative microbial solvent. What I recommend is not what you want to hear.

As for the brewing with it, its the same as GSO, Apricot for viscosity so any .45 for a first pass and then a .22 after mixing would do just fine.

I don't recommend castor oil but im sure some one will try it.
 
I was planning on making this for some friends that want it for hrt purposes - 5 shots/yr rather than 26-52. I unfortunately do not have the ability to sterilely vacuum seal vials which is why I was looking for some type of bacteriostat that wouldn't cause issues with the castor oil. If there is a way you know to set this up in an at home operation please shoot me a PM. If not is there an oil similar to castor in that it would increase the lengths of dispersion of the active ingredient to allow for several weeks between shots and still remain at a steady stead physiological level?

Thanks Powderguy for your help on this! I apologize for all the questions, just want to get all my ducks in a line before I move with this.

If I were to give this a go and do small batches in single use vials, filter through .22um then run finished vials through a pressure cooker would you think that would do the job? Also, what about the BB content. As you stated previously BB concentrations as high as those used in Aveed can cause negative effects. It has however been released to the public as a pharmaceutical so I would assume this was looked at inthe clinical trials and it was decided to be reasonably safe and not too painful to create a negative image of the drug. If anyone has any experience brewing with high BB concentration please feel free to chime in here.
 
Any OTC drug that has been approved is because it leaves the body within 24hrs. This is the standard, I like how you said reasonably safe, this is if the BB concentration doesn't cause death they will use it. BB in the system causes pain, inflammation, scarring and can thin the blood. I looked into this more and it has not been approved its in research status but the patent has been filed by the Pharm company.
I personally find it weird that test undec is being used in HRT. The ester only provides so much free test in the body compared to Cyp and Enth esters.
Feel free to chime in here fellas and tell me what you think.
Oh and heres the think and please read the warning-do the benefits outweigh the risks in castor oil--just like I told ya.

http://www.aveedusa.com/
 
Test U is most likely Big Pharma searching for compromise TRT dosing scheme. I have not come across a single article implying this. It is merely intuition from having spoken to many men who do nothing but TRT. You have two kinds of people. Those bothered by pinning. Those not. I believe most of society is still to weary of steroids to suddenly be okay with husbands pinning test cyp twice a week, or once if they listen to a doctor. On the other hand, you have pellet users. I have not heard but only the occasional praise about them. Most speak about long periods of low test. Not enough stability. Test U keeps it at pin but can be done less frequently.

With regard to castor oil, I have no comment but this, "I will never inject anything putrid."
 
Any OTC drug that has been approved is because it leaves the body within 24hrs. This is the standard, I like how you said reasonably safe, this is if the BB concentration doesn't cause death they will use it. BB in the system causes pain, inflammation, scarring and can thin the blood. I looked into this more and it has not been approved its in research status but the patent has been filed by the Pharm company.
I personally find it weird that test undec is being used in HRT. The ester only provides so much free test in the body compared to Cyp and Enth esters.
Feel free to chime in here fellas and tell me what you think.
Oh and heres the think and please read the warning-do the benefits outweigh the risks in castor oil--just like I told ya.

http://www.aveedusa.com/

Powderguy, where did you see that this is still in the research stage and is not available as a prescription? On their website it has links for doctors to register as prescribers for patients to find them as well as info on how doctors can become prescribers.

Also the same formulation but given at 4cc/shot - 1000mg test u has been approved for some time in many other countries under the brand name Nebido. This dose provides a much closer amount of free testosterone to weekly shots of 100mg of cypionate. The only difference I can tell is that Nebido (the higher dose) is available most places outside the US and UK and that Aveed (the lower dose) is approved for the US market.

I ask those questions out of curiosity but all that aside I did go ahead with a batch of this using the recipe for Aveed with the addition of 1%BA. Three people have used it, me being one of them and have had no adverse reactions. My though is to continue using weekly injections of cypionate until the a couple weeks before the third shot which is where patients arrived at a steady state in the studies. I think dropping cyp completely as soon as starting Aveed would be foolish as the cyp would get out of your system before the Aveed could really take full effect (14 weeks). I'll keep you updated on how this goes and if anyone else gives this stuff a go I would love to hear your thoughts/experiences.

Thanks again powderguy for chiming in with some very useful info, I really do appreciate having knowledgeable people around to fill in gaps and bounce ideas off of.
 
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