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Presser
02-28-2015, 11:09 AM
Testosterone enanthate at a dose of 200 mg/week decreases HDL-cholesterol levels in healthy men.
Meriggiola MC1, Marcovina S, Paulsen CA, Bremner WJ.




Abstract<abstracttext>The concept that androgen alone can provide an effective male contraceptive has been tested in a multicentre, multiphase trial by the World Health Organization. Results from this trial showed that an ester of testosterone, testosterone enanthate (TE), administered at a dose of 200 mg/week, has a very high contraceptive efficacy, and suggested that, at least in some populations, androgen alone might provide a viable option for the control of male fertility. It has been claimed that testosterone represents one of the gender-related risk factors for coronary artery disease (CAD) in men. Epidemiological and interventional studies have failed to establish a convincing relationship between testosterone and high density lipoprotein cholesterol (HDL-C). Therefore, there is concern about possible negative effects on lipoprotein asset of an androgen-alone male contraceptive. In this study we analysed the effects of long-term (12 months) administration of TE (200 mg/week) in normal healthy men. Blood samples (six men > 10 h fast = Group 1; 30 men > 4 h fast = Group 2) were drawn from 36 men, monthly before the beginning of the injections (control), every 3 months throughout the study period (treatment), and 1 month after stopping TE injections (recovery). Total cholesterol (chol), triglycerides, HDL-C and LDL-C levels were measured in these samples. Biochemical parameters were also monitored. TE administration induced a significant decrease (15-20%) in HDL-C levels that was of comparable magnitude in men from both groups (fasting and non-fasting) and occurred regardless of basal HDL-C levels. No statistically significant effect on other lipoproteins was detected. Considering all men together, HDL-C levels were decreased in 78% of the men by month 3, 83% by month 6, 94% by month 9 and 97% by month 12 of treatment. In all men the HDL-C decrease was reversible within 1 month of stopping TE administration. It is concluded that: (1) injection of 200 mg TE/week causes a 15-20% decrease in HDL-C in normal men with no effect on other lipoproteins, (2) the suppressive effect of TE is maintained throughout the 1-year-injection period, and a direct relationship between the duration of TE administration and the proportion of men showing decreased HDL-C levels, was observed. (3) The HDL-C decrease was reversible within 1 month of stopping TE administration. These data will be important in designing further studies on male contraception, and in interpreting the relationship between testosterone levels, HDL-C levels and potential cardiovascular risk.</abstracttext>

Minima
02-28-2015, 03:28 PM
That's funny cuz you have all these docs and shit trying to take away trt with injectable because of how bad it is for heart and cholesterol

Presser
02-28-2015, 03:32 PM
i thought hdl was was the good one and ldl was the bad one no?

cloudstrife1218
02-28-2015, 04:16 PM
Low hdl is bad.

cloudstrife1218
02-28-2015, 04:17 PM
You want higher hdl and low ldl

Get_Swole
02-28-2015, 04:21 PM
You want higher hdl and low ldl

+1, HDL good LDL bad, wish it worked the other way. I need to get my bloods done again asap since my HDL was a little low last time I had it checked, wonder if my test prop run has had any significant impact. Of course when I had the bloods drawn I was fat and out of shape, so hopefully it is even better now that I am 8% body fat leaner and in pretty good shape now.

Presser
02-28-2015, 04:43 PM
ok yeah thats what i thought,

Get_Swole
02-28-2015, 06:07 PM
The real question here is do you guys that cruise on 200/250 per week check your cholesterol on a regular basis? If so are you having issues keeping HDL up in normal range without medication?

I will be able to comment on this more in a few months as I will be beginning a cruise myself.

ta2dfreak
03-01-2015, 12:50 PM
What type of supplements or dietary factors can influence higher HDL levels?

cloudstrife1218
03-01-2015, 12:52 PM
Hdl is harder to augment. Ldl is easier to augment through medication.

ta2dfreak
03-01-2015, 12:55 PM
So maintaining healthy HDL is more a matter of genetics than environmental factors? Haven't had blood work done for some time and this thread is making me want to get blood drawn today :)

cloudstrife1218
03-01-2015, 12:57 PM
Hdl is a lifestyle thing. Lower ur sugar, Exercise. That kind of stuff. Quitting smoking helps. But I'm sure there is some med somewhere that can help increase it.

BEASTZ6
03-02-2015, 08:02 PM
You can do a search on Google for ways to increase your HDL naturally.