akn
Musclechemistry Member
Q: “What do you think of AOD 9604? I like the idea of promoting fat loss without the possibility of causing GH belly or nerve pain. Is it legit?”
A: AOD-9604 (HGH residues 177-191 with a tyrosine added to the N-terminus) certainly promotes fat loss in rats and mice. So far as is known, it works in them only by increasing the number and activity of beta-3 receptors.
In these species, beta-3 receptors have very high relevance to overall metabolism. In humans, the relevance is not much.
So the mechanism of action is not very promising, but leaves the possibility of at least some effect.
In human cells in vitro (in cell culture as opposed to in a living person), AOD-9604 promoted lipolysis in obese fat cells but not normal fat cells. This also seems not too promising, at least for the non-obese human user.
The company which developed it, Metabolic Pharmaceuticals, did have a small early study done which showed a small amount of fat loss at 1 mg per day but not really any other dosing. Measured effect was less at higher doses. In total the company did at least six studies. According to the lead researcher of five of the studies, Dr Gary Wittert, results were uniformly negative.
In 2007 the company abandoned development of AOD-9604 as a fat loss drug after having spent $50M on it.
I have no direct personal reports on effect of the compound. There have been a few reports put out on the Internet, but I have no better ability to summarize such findings than anyone else and generally don’t go by that, except of course I do give credence when there’s a clear, large body of results. That’s not the case here, and what there is, is certainly not in the direction of this being the next wonder.
Might the stuff have an effect? Maybe. Sometimes a small effect is hard to measure to statistical significance in a formal study.
Is it worth the cost? Almost certainly not.
Is it likely to make a large difference in your fat loss? The evidence is that it will not.
A: AOD-9604 (HGH residues 177-191 with a tyrosine added to the N-terminus) certainly promotes fat loss in rats and mice. So far as is known, it works in them only by increasing the number and activity of beta-3 receptors.
In these species, beta-3 receptors have very high relevance to overall metabolism. In humans, the relevance is not much.
So the mechanism of action is not very promising, but leaves the possibility of at least some effect.
In human cells in vitro (in cell culture as opposed to in a living person), AOD-9604 promoted lipolysis in obese fat cells but not normal fat cells. This also seems not too promising, at least for the non-obese human user.
The company which developed it, Metabolic Pharmaceuticals, did have a small early study done which showed a small amount of fat loss at 1 mg per day but not really any other dosing. Measured effect was less at higher doses. In total the company did at least six studies. According to the lead researcher of five of the studies, Dr Gary Wittert, results were uniformly negative.
In 2007 the company abandoned development of AOD-9604 as a fat loss drug after having spent $50M on it.
I have no direct personal reports on effect of the compound. There have been a few reports put out on the Internet, but I have no better ability to summarize such findings than anyone else and generally don’t go by that, except of course I do give credence when there’s a clear, large body of results. That’s not the case here, and what there is, is certainly not in the direction of this being the next wonder.
Might the stuff have an effect? Maybe. Sometimes a small effect is hard to measure to statistical significance in a formal study.
Is it worth the cost? Almost certainly not.
Is it likely to make a large difference in your fat loss? The evidence is that it will not.
