Follistatin reviews

Has anyone tried follistatin or any myostatin inhibitors? Everywhere I look they are really expensive so I don't want to blow my money on them if they are a waste of time.

Getting legit could be pain in the ass

That's what I was afraid of

I won't mind trying if someone wants to use me as a giunea pig for there product , write now I have my hands on some Chinese companys folli I'm waiting for my igf-1 to arrive than I'll start both together and update if its any good or bunk

China men are good people

Myo-x by MHP is good stuff loved it got strong as hell

I was thinking peptides. It really works?

Oh yeah they do work , but again whatever u use u have to eat clean and a lot to make good gains ,

akn said:

I won't mind trying if someone wants to use me as a giunea pig for there product , write now I have my hands on some Chinese companys folli I'm waiting for my igf-1 to arrive than I'll start both together and update if its any good or bunk

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Any sponsors reading this ?

I would like to se akn be a Folli tester for this board. As everyone knows every peptide shops sells BS folli, so it would be interesting to see what
company would dare to give u a test.

Tumbs up if you guys agree with akn getting Folli vials to test !

SwedishSteel said:

Any sponsors reading this ?

I would like to se akn be a Folli tester for this board. As everyone knows every peptide shops sells BS folli, so it would be interesting to see what
company would dare to give u a test.

Tumbs up if you guys agree with akn getting Folli vials to test !

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plus i got this baby to compare it with haven't started this folli yet , still waiting for igf-1 lr3 , this follistatin is expensive though like real expensive

I want

Keep us posted with a log bro!


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yup sure mate , if the stuff i have any good ill post a log with folli with in a weeks time u know just waiting for mc igf to arrive so i can plan it all out i like to have all in hand before startin right now just on test prop and tren ace , and hgh too lol hygetropin can vouch for this brand if u get legit stuff this shit is good will lean u up ,

I heard you have to run a lot of it to really get something out of it. Plus isn't content to the flu ?

freakinthegym said:

I heard you have to run a lot of it to really get something out of it. Plus isn't content to the flu ?

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yup ive got like 6 mgs , and there are two types ive got the untagged one fs344/315 , not the tagged one fs317/288 which give the flu like symptoms but hey will know only when i start using it lol hopefully its legit

First, understand that I am talking about what is normally called Follistatin 344 (FS344). FS344 is a particular isoform (version) that is different from FS288. Specifically, FS344 does not bind activin well (which you do not want), but still binds myostatin (which you do want). I would not suggest anyone take FS288, because although it may have the same myostatin inhibition, it could have side effects not present with FS344.

Second, FS344 turns into FS315. The FS344 protein undergoes post-translational modification that removes a 29 amino-acid signal sequence from the amino terminal end (the “front”), turning a 344 amino acid protein into a 315 amino acid protein.

Refs:

FST (follistatin)
Molecular heterogeneity of follistatin, an activ... [J Biol Chem. 1993] - PubMed - NCBI
INHIBITION OF MYOSTATIN WITH EMPHASIS ON FOLLISTATIN AS A THERAPY FOR MUSCLE DISEASE

Note that the signal peptide is cleaved off in the golgi, which is inside the cell that produced the FS in the first place. The point of that is that FS344 is actually, with “normal” FS (that is, FS produced by your body), never found in the blood stream. This is because the signal peptide was cleaved off before secretion, and so FS315 is what ends up in the blood.

I previously mentioned that the FS344->FS315 change occurs by chopping a piece off the amino-terminal (also called N-terminal) end. This is important because the N-terminal end is where myostatin binds. (See The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding : Abstract : The EMBO Journal

Conversely, the other end of the molecule, the carboxy-terminal (also called C-terminal) end, is what, in some forms, binds activin and related cell-surface molecules.

What does that tell us? Making a very broad, and perhaps inaccurate, generalization, if you screw up the N-terminal end of Follistatin, you may disrupt its myostatin binding (bad). If you screw up the C-terminal end of Follistatin, you may disrupt its activin binding (not bad – in fact, we don’t care about that at all, and it’s what we want with the FS344/315 isoform anyway.


So, FS344 and FS315 are related as FS344 generates FS315 (IN CELLS – more on that later). FS288 is not. FS288 has a precursor protein called FS317, instead of FS344. Don’t think that because FS315 and FS317 sound similar that they are. You do not want FS317 or FS288. You want FS344/FS315. And, IMHO, preferably FS315 (but good luck finding that for a reasonable price – it seems like most companies are selling FS344).

sp,e omfo regarding follistatin posted by mc member

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would update all if its any good or bunk

When will start with the follistain?

The package looked good, where did you get it?

Take it easy with the weights when on foli, it will weakens your joint a lot.
Looking forward to see a review

SwedishSteel said:

When will start with the follistain?

The package looked good, where did you get it?

Take it easy with the weights when on foli, it will weakens your joint a lot.
Looking forward to see a review

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That's is the only reason I'm waiting for igf-1 as it would help me with joint and tendon strengthening , I can get my hands on other igf but I only trust MCs and I've got big amount on way
Plan of dosing firsday straight 1 mg bilaterly in both thighs then followed by 100 mcgs ed of folli till 10 days , then would start hitting MC igf-1 lr3 then after break of ten days of folli repeat it for two more rounds
Follistatin I bought from my supplier and I trust my source 100% and the brand gear ive been using for gears and all works good but the peptide line would be the first time so let's hope it is as good as its aas , as soon as I have my MC igf order I'm shooting the folli same day lol too Mich waiting now lol