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View Full Version : HGH Bigger/Leaner...but no enhancement???



DecaDent*
07-30-2002, 06:45 PM
This is from this months J Sports Medicine,(well respected publication) says that no published studies to date show that HGH enhances athletic performance in trained athletes. This must come from the same people who say that about AAS.........it certianly doesn't mirror my experience. Maybe the need some volunteers for a real study. :D Anyways heres the abstract,what do y'all think?

Clin J Sport Med 2002 Jul;12(4):250-3 (ISSN: 1050-642X)
Dean H
Section of Pediatric Endocrinology, Department of Pediatrics, University of Manitoba, Winnipeg, Manitoba, Canada.
OBJECTIVE: To conduct a critical appraisal of the literature to address the question of whether human growth hormone (HGH) improves performance in trained athletes. DATA SOURCES: Used PubMed using the search terms of "growth hormone athletes" and the reference lists of previous reviews of the subject. STUDY SELECTION: Randomized double-blind placebo-controlled study of exogenous HGH on muscle power in trained athletes. Only one study matched the search criteria.
CONCLUSION: There is no evidence of increased muscle strength with HGH in trained athletes

BStrongBwell*
07-30-2002, 09:16 PM
hmmm.... I am well trained in statistics (unfortunately, lol) and know that any study can base conclusions on poor and/or incomplete data as part of their statistical analysis.

DecaDent*
07-30-2002, 09:33 PM
Your right BSBW,Scientists and Statasticians can both be twisted little fucks when grant money is at stake.

JizzyFoShizzy
07-31-2002, 08:39 PM
HGH acts on the liver by producing somatomedins, it is these compounds that actually produce the results associated with HGH, not the HGH itself. Physiologcially, the liver is limited in it's ability to produce somatomedis...So unlike test, for example, more is not necessarily better. HGH's main action is in the metabolism of fat and researches beleive it has no effect on muscle tissue. Thing is, it has been shown to increase the effectiveness of other hormones. In addition, HGH unlike test based hormones has a positive effect on soft tissue, namely ligaments and tendons. By strengthening these we are able to push our muscles further then we would have without the HGH. But, I would speculate that someone running HGH only would not see such profound muscle gains as he would see fat loss. On the other hand, if used in combination with another AS it can markedly improve the results obtained.

46and2aheadofme
08-01-2002, 03:48 AM
I'm curious as to the dosage and length of HGH administration in this study.

cybersteffan
08-01-2002, 05:34 AM
Originally posted by DecaDent*
CONCLUSION: There is no evidence of increased muscle strength with HGH in trained athletes

Tell that to Dorain Yates and the others :D

madchemist36
08-01-2002, 05:41 AM
i agree with cyber on that one, fuk all the bb's just ask the king of HGH RONNIE muthafuking COLEMAN. my friend met him last olympia and the one advise he got from ronnie was to take GH.

DecaDent*
08-01-2002, 02:04 PM
Originally posted by JizzyFoShizzy
HGH acts on the liver by producing somatomedins, it is these compounds that actually produce the results associated with HGH, not the HGH itself. Physiologcially, the liver is limited in it's ability to produce somatomedis...So unlike test, for example, more is not necessarily better. HGH's main action is in the metabolism of fat and researches beleive it has no effect on muscle tissue. Thing is, it has been shown to increase the effectiveness of other hormones. In addition, HGH unlike test based hormones has a positive effect on soft tissue, namely ligaments and tendons. By strengthening these we are able to push our muscles further then we would have without the HGH. But, I would speculate that someone running HGH only would not see such profound muscle gains as he would see fat loss. On the other hand, if used in combination with another AS it can markedly improve the results obtained.

Good point Jizzy

Shredded
08-01-2002, 03:11 PM
Ok someone correct me on this. Yes HGH acts on the tendons and ligaments and works better with the additional use of steroids, but I was also told that HGH unlike steroids actually increased the number of muscles cells where steroids only increased there size. Is this not correct? I was also told that this is dosage dependent and that at the lower dosages the main effects were the tendon, ligament and fat changes, while the larger dosages, mainly in the range of 4 iu to 16 iu per day involved a further increase in the quantity of muscle cells and also may require the additional us of insulin.
Right or wrong?

caladin
08-01-2002, 03:23 PM
yea what shredded says!

DecaDent*
08-01-2002, 04:01 PM
That was my understanding as well Shredded,I'm not sure if it's research based conclusions or just anecdotal evidence that makes people say that.especially the dose dependant part you commented on with HGH. I found this study,although it is in dogs,it did show a hypertrophic effect on Type1 and Type 2 muscle fibers that was not dependent on edema. I'm still searching for a good "people" or better yet "athlete" study.



Effect of chronic growth hormone administration on skeletal muscle in dogs.


Administration of growth hormone (GH) results in increased body weight gain in dogs. Increased body weight gain is believed to be a result of the trophic effect of GH on the musculoskeletal system. However, edema is one of the side effects described in man following exogenous GH administration. Thus, the objective of this study was to determine if the expected increased weight gain in GH-treated dogs is a result of increased muscle mass. Porcine growth hormone (pGH), administered subcutaneously to beagle dogs at doses of 0.025, 0.1, and 1 IU/kg/day for 14 wk, resulted in elevated serum GH and insulin-like growth factor-1 (IGF-1) levels (see accompanying paper, Prahalada et al). This was associated with a significant increase in body weight gain and weights of the cranial tibialis muscle in both male and female dogs. The increased muscle mass likely contributed to the significant increase in body weight gain seen in both sexes. Quantitative analysis of skeletal muscle sections stained for ATPase activity showed increases in type I (slow twitch) and type II (fast twitch) myofiber sizes in mid- and high-dose males and in high-dose females. The ratio of type I and type II muscle fibers remained unchanged. Hypertrophic myofibers were enlarged but had a normal histologic and ultrastructural organization when observed by light and transmission electron microscopy. The results of this study have demonstrated that increased muscle mass in pGH-treated dogs is related to hypertrophy of muscle fibers and not due to edema. Exogenous GH administration has an anabolic effect on skeletal muscle in dogs.


Toxicol Pathol 1998 Mar-Apr;26(2):207-12 (ISSN: 0192-6233)
Molon-Noblot S; Laroque P; Prahalada S; Stabinski LG; Hoe CM; Peter CP; Duprat P; van Zwieten MJ
Merck Sharp & Dohme-Chibret Laboratories, Department of Safety Assessment, Riom, France