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View Full Version : Growth factors improve muscle healing. IGF-1 , Long R3 IGF-1 Regeneration Study



gandhisays
08-27-2015, 02:36 PM
Growth factors improve muscle healing in vivo

[*=left]J. Menetrey (http://www.bjj.boneandjoint.org.uk/search?author1=J.+Menetrey&sortspec=date&submit=Submit), MD1 (http://www.bjj.boneandjoint.org.uk/content/82-B/1/131.short#aff-1);
[*=left]C. Kasemkijwattana (http://www.bjj.boneandjoint.org.uk/search?author1=C.+Kasemkijwattana&sortspec=date&submit=Submit), MD1 (http://www.bjj.boneandjoint.org.uk/content/82-B/1/131.short#aff-1);
[*=left]C. S. Day (http://www.bjj.boneandjoint.org.uk/search?author1=C.+S.+Day&sortspec=date&submit=Submit), MD1 (http://www.bjj.boneandjoint.org.uk/content/82-B/1/131.short#aff-1);
[*=left]P. Bosch (http://www.bjj.boneandjoint.org.uk/search?author1=P.+Bosch&sortspec=date&submit=Submit), MD1 (http://www.bjj.boneandjoint.org.uk/content/82-B/1/131.short#aff-1);
[*=left]M. Vogt (http://www.bjj.boneandjoint.org.uk/search?author1=M.+Vogt&sortspec=date&submit=Submit), PhD2 (http://www.bjj.boneandjoint.org.uk/content/82-B/1/131.short#aff-2);
[*=left]F. H. Fu (http://www.bjj.boneandjoint.org.uk/search?author1=F.+H.+Fu&sortspec=date&submit=Submit), MD1 (http://www.bjj.boneandjoint.org.uk/content/82-B/1/131.short#aff-1);
[*=left]M. S. Moreland (http://www.bjj.boneandjoint.org.uk/search?author1=M.+S.+Moreland&sortspec=date&submit=Submit), MD2 (http://www.bjj.boneandjoint.org.uk/content/82-B/1/131.short#aff-2); and
[*=left]J. Huard (http://www.bjj.boneandjoint.org.uk/search?author1=J.+Huard&sortspec=date&submit=Submit), PhD2 (http://www.bjj.boneandjoint.org.uk/content/82-B/1/131.short#aff-2)

+ (http://www.bjj.boneandjoint.org.uk/content/82-B/1/131.short#)Author Affiliations

<address style="margin: 0px; padding: 0px; border: 0px; outline-style: none; font-weight: inherit; font-style: normal; font-size: inherit; font-family: inherit; line-height: inherit; text-align: inherit; vertical-align: baseline; display: inline;">1Department of Orthopaedic Surgery, Musculoskeletal Research Centre, Division of Sports Medicine, Athletic Department.</address>
<address style="margin: 0px; padding: 0px; border: 0px; outline-style: none; font-weight: inherit; font-style: normal; font-size: inherit; font-family: inherit; line-height: inherit; text-align: inherit; vertical-align: baseline; display: inline;">2Department of Orthopaedic Surgery, Musculoskeletal Research Centre Children’s Hospital of Pittsburgh and the University of Pittsburgh, Pitts-burgh, Pennsylvania 15261, USA.</address>



Correspondence should be sent to Dr J. Huard.


AbstractInjury to muscles is very common. We have previously observed that basic fibroblast growth factor (b-FGF), insulin growth factor type 1 (IGF-1) and nerve growth factor (NGF) are potent stimulators of the proliferation and fusion of myoblasts in vitro. We therefore injected these growth factors into mice with lacerations of the gastrocnemius muscle. The muscle regeneration was evaluated at one week by histological staining and quantitative histology. Muscle healing was assessed histologically and the contractile properties were measured one month after injury.Our findings showed that b-FGF, IGF and to a less extent NGF enhanced muscle regeneration in vivo compared with control muscle. At one month, muscles treated with IGF-1 and b-FGF showed improved healing and significantly increased fast-twitch and tetanus strengths. Our results suggest that b-FGF and IGF-1 stimulated muscle healing and may have a considerable effect on the treatment of muscle injuries.


Received March 19, 1998.
Accepted March 5, 1999.



© 2000 British Editorial Society of Bone and Joint Surgery

Presser
01-04-2016, 12:01 PM
bump it up!

Presser
01-30-2019, 12:23 PM
Amen to that! I just posted in another IGF 1 study showing this healing effect of igf 1. Half my bicep tore off the bone in december, maybe more like 30% but it looks like dog shit! And i have been using a shit ton of IGF in my bicep muscle and hoping between that and the surgery that it heals 100%

Presser
03-31-2019, 11:13 PM
Great post