advanced recipe need optimization

Hello.
First im new there, i read a lot of forum but rarely participate so i will be bref.
I'm french too
i have been doing a couple of recipe. I do a lot of experience on my free time since im in my first years of biochemistry at university.
Now.
My oil recipe is pretty good i use chlorobutanol instead of benzyl alcohol. I use a mini-mixture of eo and benzyl salicylate at really low percentage to only help a little bit to enhance my raw solubility and avoid any pain caused by allergic reaction. I also micronized my raw by precipitation method using solvent and anti-solvent followed by vaccum drying. It help with better assimilation since my crystal are theoricly in amorphous phase so they have a larger wettable area ( aint sure if its the good english term sorry). But it doesnt enhance the solute solubility in my oil. Im using different ratio of castor oil and cottonseed oil to give my finish product a decent viscosity. And i dont have any documentation if a more viscous carrier like castor oil will really absorb more raw than a thinner one. Any evidence on that would be welcome .

I dont have ton of raw so i try to optimise my experience.
Im preparing to start a winny batch . Inhave set up a recipe like the testosterone suspension pharmaceutical company use but i need help. Since my equipment are farrr away from the pharma one, i have to work harder on my excipient-content ( solvent.cosolvent. ph regulator etc.. ) . For now i will use a saline water, potassium citrate and sodium citrate as my solution buffer. I have read a essay recently promoting the use of l-methionine to help stabilize PH over 12 month and more, where a common buffer solution have a decrease in PH after 3 month and after 6 month the PH is already below 2.5 .I will also use really low amount of polysorbate to avoid deflocculating .i would use between 0.10% to 0.75% of polysorbate 80(preferably between 0.15% and 0.25%). I think i will need a a antioxidant if i try my trenbolone base suspension to avoid it to become dark red. My antimicrobial agent should be benzalkonium chloride since its an cationic surfactant (really useful since it help to reduce repulsive charge between my micronized raw). Now i was thinking about the use of a chelating agent to reduce the metal ion in my suspension. I have some nf lecithin that i could possibly use as wetting agent but i dont know how to calculate the percentage needed with the polysorbate 80 to get an HLB between 7-9 since the ps80 have a high hlb value ( and im not willing to buy polysorbate 20 becaude i need to buy a shit load of it to get a decent purity and i dont think i really meed it) . Isotoniticy can be easily achieve with a low level of dextrose in my suspension. Now that i think i have all my basic ingredient, before starting it i wanna be sure and need some good advice or if i have some modification everything is welcome i just want to have a heaven-like winny injection because i really hate any tip of pip or muscle pain ! And i fucking got trenbolone base instead of trenbolone acetate so i have to find a way to use it ahahaha ! Please help me

If you want o simply make test suspension you are way over thinking this my friend. Here's what you need for 20 ml at 100mg/ml
First simple bacteria static water in a sterile vial. I'm guessing on the amount because I didn't look at my recipie but I think its 14.75ml bacteriostatic water or distilled water and. 09% BA

Next you add 2 g raw test no ester into another vial or beakers I find a 30mo vial works easier. Add to that 20% BB, . 6ML polysorbate 80 and heat until liquid but heat until it's melting point. Let it cool. You want to filter it warm but not to exceed max temp of the filter. I use Whatman syringe filters for this. And I filter 1 to 2ml at a time.

I also leave another 30ml vial on the burner just warm and in between dating and filtering I will rest the filter on that empty vial to keep the filter warm so the suspension doesn't crash in it.

The poly80 is a surfactant.

You need to shake vigorously firv20 or 30 seconds after each 1 to 2ml filtered this will not separate. It will stay completely white throughout.


Also how do you like the benzyl salicylate? I've been considering that, and miglylol 840 if I can find it.

Benzyl salicylate is pretty good i can overdose my test prop to 150 mg without any pain . Not any chance of allergy reaction due to low amount ! And your recipe is proven to be wrong sorry all the win depot on the market and all the homebrew have lot of pain. i have read several study stating that the amount of polysorbate 80 you use is waaaaayyyyy too much ! Its supposed to create a micelle not a liposome. I want to develop a really good recipe to lower toxicity level of all your formulation. What you are doing is not water-based... its more like solvent based lollll. With the explanation you gave me i see that you have good understanding of the basic but i dont want to stay in the basic ways and stay with a shitty product ! With putting this much solvent you are creating more pain than avoiding ! And for the melt extrusion, you could easily sterilise your carrier than mix raw material in acetone until its all dissolve, filter the mix directly into the carrier. It will micronize the same way than melt extrusion but will be far easier ( acetone is nonpolar and water will act like an antisolvent that will crash the raw ) after you only have siphonne the supernatant liquid and if you are uncertain with it you can let it evaporate a short time. Thats exactly the ways pharma are doing the testosterone suspension. Personnaly i would not inject hydrochloric acid ( PH approximatly 2.5) . The ways you did your formulation your PH (if you are lucky) will be around 6, and after 3month it will be like 2-3 .... be careful man it really damaged your muscle cell

Actually there is no pain in the method so we all have our opinions yes it's broke down into solvents as an injectable will be but then it's added to a base of water being the majority ~ 75% of the suspension. Make it as you will but I've been a this for 15 years or so and have made this many times. Actually I did write out the recipe incorrect because I will use a small amount of guaiacol as well. No water based solution is simply water based so I guess I miss what you are saying but if your asking how it's made you don't have to take my advice, and I can guarantee it's not shit and is the same as any that make it but if you look in the sticky for recipes you will be fine.

With the benzyl salicylate what percentage?

It was "joke" comparaison. I meant that a suspension is not supposed to have so much solvent... if you look at usp specification for a suspension you will see that your recipe is wayyyss to toxic

It was "joke" comparaison. I meant that a suspension is not supposed to have so much solvent... if you look at usp specification for a suspension you will see that your recipe is wayyyss to toxic