Can I Take T3 or T4 Thyroid Hormones at the same time as using Insulin -like Growth Factor-1 (IGF-1) or (LongR3 IGF-1) Long R3 IGF-1 Being the more potent and longer acting making it a favorite among bodybuilders, and All Athletes who may want to pay close attention to this report.
One must always understand there is always a cause and effect, or counter effect when combining two seperate hormones in the body by exogenous and or oral means.
Lets Explore the relationship of the T3 thyroid hormone when taken with or alongside insulin like growth factor-1.
Thyroid Hormone (T3) in conjunction with IGF-1
Danish researchers recently examined this interplay, report in the results in the American Journal of Physiology (32;E840-E845, i995). Most hormones, including growth hormone, thyroid, testosterone and IGF-1, are carried in the blood bound to proteins. Such hormone and protein carriers are considered "storage" forms of the hormone, since only the unbound or "free" hormone can interact with cellular receptors and begin the process associated with that particular hormone.
Using rats as subjects, the researchers administered various doses of thyroid hormone to the animals, then quantified their IGF-1 responses using a newly developed sophisticated test. What they found was that larger doses of thyroid hormone caused an increase in 1GF-1-binding proteins. This, in turn, caused a decrease in the free levels of circulating IGF-1. The amount of thyroid hormone, however, wasn't enough to cause a catabolic or muscle-protein breakdown sequence in the rats.
Since IGF-1 is the main anabolic stimulus behind (G.H.) growth hormone, taking thyroid hormones may inhibit the effects of this hormone in muscle by causing it to become tied up in its blood-binding proteins. HOWEVER....This could also contribute to the general muscle catabolism often seen with the use of exogenous thyroid hormones.
One must always understand there is always a cause and effect, or counter effect when combining two seperate hormones in the body by exogenous and or oral means.
Lets Explore the relationship of the T3 thyroid hormone when taken with or alongside insulin like growth factor-1.
Thyroid Hormone (T3) in conjunction with IGF-1
Danish researchers recently examined this interplay, report in the results in the American Journal of Physiology (32;E840-E845, i995). Most hormones, including growth hormone, thyroid, testosterone and IGF-1, are carried in the blood bound to proteins. Such hormone and protein carriers are considered "storage" forms of the hormone, since only the unbound or "free" hormone can interact with cellular receptors and begin the process associated with that particular hormone.
Using rats as subjects, the researchers administered various doses of thyroid hormone to the animals, then quantified their IGF-1 responses using a newly developed sophisticated test. What they found was that larger doses of thyroid hormone caused an increase in 1GF-1-binding proteins. This, in turn, caused a decrease in the free levels of circulating IGF-1. The amount of thyroid hormone, however, wasn't enough to cause a catabolic or muscle-protein breakdown sequence in the rats.
Since IGF-1 is the main anabolic stimulus behind (G.H.) growth hormone, taking thyroid hormones may inhibit the effects of this hormone in muscle by causing it to become tied up in its blood-binding proteins. HOWEVER....This could also contribute to the general muscle catabolism often seen with the use of exogenous thyroid hormones.
