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View Full Version : Does Masteron (DHT, Drostanolone Propionate) Lower / Decrease Cortisol Levels?



Area 1255
12-19-2016, 09:19 PM
Original Article Link --> https://area1255.blogspot.com/2016/11/does-masteron-dht-drostanolone.html

:::Q:::
"Area, does Masteron have an effect on Cortisol? Does it decrease cortisol levels?"


~Dave Q


:::A:::
Research shows that Dihydrotestosterone inhibits the HPTA stress response by cross-activating estrogen-Receptor beta, this causes a decrease in circulating corticosteroids, strong compounds, like Masteron, tend to have direct blocking action on Cortisol, by acting both at the hypothalamus and by acting on beta-endorphin related pathways [!].


So Yes, Masteron absolutely can lower Cortisol levels.


Perhaps not as much as more ''official'' cortisol blockers, but it does to an extent.


***SOURCES***


Horm Behav. Author manuscript; available in PMC 2013 Jan 1.
Published in final edited form as:
Horm Behav. 2012 Jan; 61(1): 147–155.
Published online 2011 Oct 1. doi: 10.1016/j.yhbeh.2011.09.010
PMCID: PMC3264812
NIHMSID: NIHMS334274
TESTOSTERONE AND SPORT: CURRENT PERSPECTIVES (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264812/)


Drostanolone Propionate : Chemical Database and Readout by PubChem (https://pubchem.ncbi.nlm.nih.gov/compound/drostanolone_propionate#section=2D-Structure)@NIH - National Institutes of Health (https://plus.google.com/110708572999188294877)


J Neurosci. 2006 Feb 1;26(5):1448-56.

The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus. (https://www.ncbi.nlm.nih.gov/pubmed/016452668)

Iron Game
12-20-2016, 04:39 AM
I edited out the Source Sites but thanks for the information.