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View Full Version : Testosterone Gel Administered In Older men for a Period Over 3 Years Was Studied Against Placebo given over the same period to study participants



big in vegas
07-17-2018, 09:41 AM
Hold on to your hats, You wont believe this new 2017 published study! on Testosterone effects over 3 years in older adult makes!

Apparently When Men Are given Testosterone gel They outperform their studied counterparts who were given a placebo. Not just outperform, but significantly greater in exercise, muscle mass, and power.

Oh my Gosh , who knew?











Effects of Testosterone Supplementation for 3 Years on Muscle Performance and Physical Function in Older Men.
Storer TW (https://www.ncbi.nlm.nih.gov/pubmed/?term=Storer%20TW%5BAuthor%5D&cauthor=true&cauthor_uid=27754805)1, Basaria S (https://www.ncbi.nlm.nih.gov/pubmed/?term=Basaria%20S%5BAuthor%5D&cauthor=true&cauthor_uid=27754805)1, Traustadottir T (https://www.ncbi.nlm.nih.gov/pubmed/?term=Traustadottir%20T%5BAuthor%5D&cauthor=true&cauthor_uid=27754805)2,3, Harman SM (https://www.ncbi.nlm.nih.gov/pubmed/?term=Harman%20SM%5BAuthor%5D&cauthor=true&cauthor_uid=27754805)2,4, Pencina K (https://www.ncbi.nlm.nih.gov/pubmed/?term=Pencina%20K%5BAuthor%5D&cauthor=true&cauthor_uid=27754805)1, Li Z (https://www.ncbi.nlm.nih.gov/pubmed/?term=Li%20Z%5BAuthor%5D&cauthor=true&cauthor_uid=27754805)1, Travison TG (https://www.ncbi.nlm.nih.gov/pubmed/?term=Travison%20TG%5BAuthor%5D&cauthor=true&cauthor_uid=27754805)1,5, Miciek R (https://www.ncbi.nlm.nih.gov/pubmed/?term=Miciek%20R%5BAuthor%5D&cauthor=true&cauthor_uid=27754805)6,7, Tsitouras P (https://www.ncbi.nlm.nih.gov/pubmed/?term=Tsitouras%20P%5BAuthor%5D&cauthor=true&cauthor_uid=27754805)2,8, Hally K (https://www.ncbi.nlm.nih.gov/pubmed/?term=Hally%20K%5BAuthor%5D&cauthor=true&cauthor_uid=27754805)1, Huang G (https://www.ncbi.nlm.nih.gov/pubmed/?term=Huang%20G%5BAuthor%5D&cauthor=true&cauthor_uid=27754805)1, Bhasin S (https://www.ncbi.nlm.nih.gov/pubmed/?term=Bhasin%20S%5BAuthor%5D&cauthor=true&cauthor_uid=27754805)1.
Author information (https://www.ncbi.nlm.nih.gov/pubmed/27754805#)

AbstractContext:Findings of studies of testosterone's effects on muscle strength and physical function in older men have been inconsistent; its effects on muscle power and fatigability have not been studied.
Objective:To determine the effects of testosterone administration for 3 years in older men on muscle strength, power, fatigability, and physical function.
Design, Setting, and Participants:This was a double-blind, placebo-controlled, randomized trial of healthy men ≥60 years old with total testosterone levels of 100 to 400 ng/dL or free testosterone levels <50 pg/mL.
Interventions:Random assignment to 7.5 g of 1% testosterone or placebo gel daily for 3 years.
Outcome Measures:Loaded and unloaded stair-climbing power, muscle strength, power, and fatigability in leg press and chest press exercises, and lean mass at baseline, 6, 18, and 36 months.
Results:The groups were similar at baseline. Testosterone administration for 3 years was associated with significantly greater performance in unloaded and loaded stair-climbing power than placebo (mean estimated between-group difference, 10.7 W [95% confidence interval (CI), -4.0 to 25.5], P = 0.026; and 22.4 W [95% CI, 4.6 to 40.3], P = 0.027), respectively. Changes in chest-press strength (estimated mean difference, 16.3 N; 95% CI, 5.5 to 27.1; P < 0.001) and power (mean difference 22.5 W; 95% CI, 7.5 to 37.5; P < 0.001), and leg-press power were significantly greater in men randomized to testosterone than in those randomized to placebo. Lean body mass significantly increased more in the testosterone group.
Conclusion:Compared with placebo, testosterone replacement in older men for 3 years was associated with modest but significantly greater improvements in stair-climbing power, muscle mass, and power. Clinical meaningfulness of these treatment effects and their impact on disability in older adults with functional limitations remains to be studied.
TRIAL REGISTRATION:ClinicalTrials.gov NCT00287586 (http://clinicaltrials.gov/show/NCT00287586).
Copyright © 2017 by the Endocrine Society



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