HackTwat
MuscleChemistry Registered Member
[h=1]Below are a couple of studies done with GHRP-6 that I found quite interesting. This Peptide seems very promising indeed........
Growth hormone responses to GH-releasing peptide (GHRP-6) in hypothyroidism.[/h]Pimentel-Filho FR, Ramos-Dias JC, Ninno FB, Façanha CF, Liberman B, Lengyel AM.
[h=3]Author information [/h]
[h=3]Abstract[/h][h=4]OBJECTIVE:[/h]Both spontaneous and stimulated GH secretion are reduced in patients with hypothyroidism. The mechanisms involved in these alterations are not yet fully understood. GHRP-6 is a synthetic hexapeptide that releases GH both in vivo and in vitro. Its mechanism of action is unknown, but there is evidence that this peptide acts as a functional somatostatin antagonist at pituitary level. The aim of this study was to evaluate the GH response to GHRP-6 in patients with primary hypothyroidism and in normal controls.
[h=4]DESIGN:[/h]Patients with hypothyroidism and normal controls were randomly submitted to 3 tests with GHRH (100 micrograms i.v.), GHRP-6 (1 microgram/kg i.v.) and GHRH + GHRP-6, on separate days.
[h=4]PATIENTS:[/h]Eleven patients with primary hypothyroidism were compared with 10 control subjects.
[h=4]MEASUREMENTS:[/h]GH, TSH and free T4 were measured by immunofluorometric assay and IGF-1 by radioimmunoassay.
[h=4]RESULTS:[/h]Hypothyroid patients had markedly lower peak GH values (mean +/- SE micrograms/l) after GHRH administration (4.1 +/- 0.9) compared to control subjects (24.9 +/- 5.1). After GHRP-6 injection hypothyroid patients had a significantly higher GH release (12.6 +/- 1.9) than that obtained with GHRH, while in control subjects GH values were similar (22.1 +/- 3.6). No significant differences in peak GH responses were observed following the administration of either GHRP-6 alone (controls 22.1 +/- 3.6; patients 12.6 +/- 1.9) or in combination with GHRH (controls 77.4 +/- 15.0; patients 52.8 +/- 10.9), despite the trend to smaller responses in hypothyroid patients.
[h=4]CONCLUSION:[/h]We have shown that patients with primary hypothyroidism have higher GH responses to GHRP-6 than to GHRH, which are markedly blunted. When GHRP-6 was associated with GHRH, a significant increase in the GH response was observed in these patients, which could suggest a role for somatostatin in this process. Our data suggest that thyroid hormones modulate GH release induced by GHRH and GHRP-6 through different mechanisms. However, additional studies are necessary to further elucidate this hypothesis.
[h=1]Growth hormone secretion after the administration of GHRP-6 or GHRH combined with GHRP-6 does not decline in late adulthood.[/h]Micic D, Popovic V, Kendereski A, Macut D, Casanueva FF, Dieguez C.
[h=3]Author information [/h]
[h=3]Abstract[/h][h=4]OBJECTIVE:[/h]Growth hormone (GH) secretion in middle and late adulthood declines with age. However, the precise mechanisms causing this impairment in GH release are unknown. His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6) is a synthetic compound that releases GH in a dose related and specific manner in several species, including man. In order to gain a further insight into disrupted GH secretion in late adulthood, we evaluated GH responses to GHRP-6 or GHRH, administered either alone or in combination, in healthy young and late adulthood groups of subjects.
[h=4]DESIGN:[/h]All subjects underwent three different tests carried out in random order and separated by at least one week. Tests were performed at 0900 h after an overnight fast. GHRH (100 micrograms), GHRP-6 (90 micrograms) either alone or in combination were administered as an i.v. bolus.
[h=4]SUBJECTS:[/h]Groups of healthy young (mean +/- SEM 22 +/- 1.1 years, n = 9) and older adult subjects (59.5 +/- 1.7 years, n = 9) were studied.
[h=4]MEASUREMENTS:[/h]Serum GH levels were measured by radioimmunoassay.
[h=4]RESULTS:[/h]In the group of young adult subjects the combined administration of GHRH and GHRP-6 elicited a greater GH increase than GHRH alone (F = 21.9, P < 0.001) or GHRP-6 alone (F = 6.2, P = 0.01). Similarly, the response to the combined stimuli was also greater than with GHRH alone (F = 21.8, P < 0.001) or GHRP-6 alone (F = 23.9, P < 0.001) in the late adulthood group of subjects. GH responses to GHRH were greater in younger than in older subjects (F = 3.45, P = 0.03). In contrast, GH responses to either GHRP-6 (F = 0.71, P = NS) or combined GHRH plus GHRP-6 administration (F = 0.68, P = NS) were not significantly different between the two groups.
[h=4]CONCLUSIONS:[/h]These data show that GH responses to GHRP-6 are much greater than to GHRH in late adulthood. The marked increase of plasma GH levels observed after administration of GHRP-6 alone or in combination with GHRH indicates that impaired GH secretion in late adulthood is a functional and potentially reversible state.
- - - Updated - - -
What is GHRP-6????
GHRP-6 stands for Growth Hormone Releasing Peptide ? 6. It is a 28-amino-acid peptide, which indicates the human body to begin secreting growth-hormone (GH). It is often used as an energy generator. It affects the Growth Hormone strongly. Its main work is to stimulate hunger by promoting food intake and aid in energy metabolism. It can fulfill the deficient GH, cachexia and can be used to treat eating disorders and obesity. It is a Ghrelin antagonist which fights against Grehlin and this mechanism helps to reduce body fat.
GHRP-6 has become very popular as it enhances your body performance. It helps in increasing strength and muscle mass. It facilitates body fat loss, and helps to rejuvenate strengths of joints, and triggers up liver in secreting IGF-1. GHRP-6 is a synthetic hexapeptide that helps stimulating release of growth hormone. It also helps to stimulate the anterior pituitary gland.
GHRP-6 isn't usually used by women because it makes them gain weight too quickly. If you take the medicine dose 100mcg/day, you won't find the extreme hunger that is caused by a high dose. A 5mg bottle of GHRP-6 is going to last for months and that's enough time to rehab any injury. The doses of GHRP-6 could range from 100mcg/day injected to 500mcg/day.
If you take this medicine post-workout, it helps you to take full advantage of the appetite and anabolic properties it shows. Bodybuilders and athletes use this drug in an effort to build more muscle and burn more fat. Some of them use it post cycles in an effort to re-start their body into producing their own natural GH and IGF.
However, there are several side-effects associated with GHRP-6. One of the most common side effects of GHRP-6 is extreme hunger which it produces within an hour of injection. As it increases your appetite due to a stimulating release of Gherlin, which is released naturally in the lining of stomach which results in gastric emptying.
Growth hormone responses to GH-releasing peptide (GHRP-6) in hypothyroidism.[/h]Pimentel-Filho FR, Ramos-Dias JC, Ninno FB, Façanha CF, Liberman B, Lengyel AM.
[h=3]Author information [/h]
- Division of Endocrinology, Universidade Federal de São Paulo/Escola Paulista de Medicina-UNIFESP/EPM, Brazil.
[h=3]Abstract[/h][h=4]OBJECTIVE:[/h]Both spontaneous and stimulated GH secretion are reduced in patients with hypothyroidism. The mechanisms involved in these alterations are not yet fully understood. GHRP-6 is a synthetic hexapeptide that releases GH both in vivo and in vitro. Its mechanism of action is unknown, but there is evidence that this peptide acts as a functional somatostatin antagonist at pituitary level. The aim of this study was to evaluate the GH response to GHRP-6 in patients with primary hypothyroidism and in normal controls.
[h=4]DESIGN:[/h]Patients with hypothyroidism and normal controls were randomly submitted to 3 tests with GHRH (100 micrograms i.v.), GHRP-6 (1 microgram/kg i.v.) and GHRH + GHRP-6, on separate days.
[h=4]PATIENTS:[/h]Eleven patients with primary hypothyroidism were compared with 10 control subjects.
[h=4]MEASUREMENTS:[/h]GH, TSH and free T4 were measured by immunofluorometric assay and IGF-1 by radioimmunoassay.
[h=4]RESULTS:[/h]Hypothyroid patients had markedly lower peak GH values (mean +/- SE micrograms/l) after GHRH administration (4.1 +/- 0.9) compared to control subjects (24.9 +/- 5.1). After GHRP-6 injection hypothyroid patients had a significantly higher GH release (12.6 +/- 1.9) than that obtained with GHRH, while in control subjects GH values were similar (22.1 +/- 3.6). No significant differences in peak GH responses were observed following the administration of either GHRP-6 alone (controls 22.1 +/- 3.6; patients 12.6 +/- 1.9) or in combination with GHRH (controls 77.4 +/- 15.0; patients 52.8 +/- 10.9), despite the trend to smaller responses in hypothyroid patients.
[h=4]CONCLUSION:[/h]We have shown that patients with primary hypothyroidism have higher GH responses to GHRP-6 than to GHRH, which are markedly blunted. When GHRP-6 was associated with GHRH, a significant increase in the GH response was observed in these patients, which could suggest a role for somatostatin in this process. Our data suggest that thyroid hormones modulate GH release induced by GHRH and GHRP-6 through different mechanisms. However, additional studies are necessary to further elucidate this hypothesis.
[h=1]Growth hormone secretion after the administration of GHRP-6 or GHRH combined with GHRP-6 does not decline in late adulthood.[/h]Micic D, Popovic V, Kendereski A, Macut D, Casanueva FF, Dieguez C.
[h=3]Author information [/h]
- Institute of Endocrinology, University Clinical Center, Belgrade, Yugoslavia.
[h=3]Abstract[/h][h=4]OBJECTIVE:[/h]Growth hormone (GH) secretion in middle and late adulthood declines with age. However, the precise mechanisms causing this impairment in GH release are unknown. His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6) is a synthetic compound that releases GH in a dose related and specific manner in several species, including man. In order to gain a further insight into disrupted GH secretion in late adulthood, we evaluated GH responses to GHRP-6 or GHRH, administered either alone or in combination, in healthy young and late adulthood groups of subjects.
[h=4]DESIGN:[/h]All subjects underwent three different tests carried out in random order and separated by at least one week. Tests were performed at 0900 h after an overnight fast. GHRH (100 micrograms), GHRP-6 (90 micrograms) either alone or in combination were administered as an i.v. bolus.
[h=4]SUBJECTS:[/h]Groups of healthy young (mean +/- SEM 22 +/- 1.1 years, n = 9) and older adult subjects (59.5 +/- 1.7 years, n = 9) were studied.
[h=4]MEASUREMENTS:[/h]Serum GH levels were measured by radioimmunoassay.
[h=4]RESULTS:[/h]In the group of young adult subjects the combined administration of GHRH and GHRP-6 elicited a greater GH increase than GHRH alone (F = 21.9, P < 0.001) or GHRP-6 alone (F = 6.2, P = 0.01). Similarly, the response to the combined stimuli was also greater than with GHRH alone (F = 21.8, P < 0.001) or GHRP-6 alone (F = 23.9, P < 0.001) in the late adulthood group of subjects. GH responses to GHRH were greater in younger than in older subjects (F = 3.45, P = 0.03). In contrast, GH responses to either GHRP-6 (F = 0.71, P = NS) or combined GHRH plus GHRP-6 administration (F = 0.68, P = NS) were not significantly different between the two groups.
[h=4]CONCLUSIONS:[/h]These data show that GH responses to GHRP-6 are much greater than to GHRH in late adulthood. The marked increase of plasma GH levels observed after administration of GHRP-6 alone or in combination with GHRH indicates that impaired GH secretion in late adulthood is a functional and potentially reversible state.
- - - Updated - - -
What is GHRP-6????
GHRP-6 stands for Growth Hormone Releasing Peptide ? 6. It is a 28-amino-acid peptide, which indicates the human body to begin secreting growth-hormone (GH). It is often used as an energy generator. It affects the Growth Hormone strongly. Its main work is to stimulate hunger by promoting food intake and aid in energy metabolism. It can fulfill the deficient GH, cachexia and can be used to treat eating disorders and obesity. It is a Ghrelin antagonist which fights against Grehlin and this mechanism helps to reduce body fat.
GHRP-6 has become very popular as it enhances your body performance. It helps in increasing strength and muscle mass. It facilitates body fat loss, and helps to rejuvenate strengths of joints, and triggers up liver in secreting IGF-1. GHRP-6 is a synthetic hexapeptide that helps stimulating release of growth hormone. It also helps to stimulate the anterior pituitary gland.
GHRP-6 isn't usually used by women because it makes them gain weight too quickly. If you take the medicine dose 100mcg/day, you won't find the extreme hunger that is caused by a high dose. A 5mg bottle of GHRP-6 is going to last for months and that's enough time to rehab any injury. The doses of GHRP-6 could range from 100mcg/day injected to 500mcg/day.
If you take this medicine post-workout, it helps you to take full advantage of the appetite and anabolic properties it shows. Bodybuilders and athletes use this drug in an effort to build more muscle and burn more fat. Some of them use it post cycles in an effort to re-start their body into producing their own natural GH and IGF.
However, there are several side-effects associated with GHRP-6. One of the most common side effects of GHRP-6 is extreme hunger which it produces within an hour of injection. As it increases your appetite due to a stimulating release of Gherlin, which is released naturally in the lining of stomach which results in gastric emptying.
