Not a fan of secretagogues when you can administer the end result igf-1 directly, however its still one of the better secretagogues among its class and shows elevated igf-1 level in humans with just one dosage for nearly a full day, so below is a quick profile of mk-677 for anyone interested in running a cycle of it if thats all you can get your hands on lol

Ibutamoren or MK677 or GHAR1NE is a non-peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and a growth hormone secretagogue. To learn more about Ibutamoren visit What is GHAR1NE?


  • Generic/Nonproprietary Name: Ibutamoren
  • Developmental Code Names: MK-677, MK-0677, L-163,191
  • Trade/Brand Names: GHAR1NE
  • Chemical Nomenclature: (R)-1′-(2-methylalanyl-O-benzyl-D-seryl)-1-(methylsulfonyl)-1,2-dihydrospiro[indole-3,4′-piperidine]
  • Synonyms: 2-Amino-2-methyl-N-[1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-(phenylmethoxy)propan-2-yl]propanamide
  • Molecular Mass/Weight: 528.662 g/mol
  • Legal Status: Unscheduled (US)
  • Oral Bioavailability: Above 30% (in dogs)
  • Biological Half-Life: 4-6 hours (in beagles); IGF-1 levels remain elevated in humans with a single oral dose for up to 24 hours
  • Methylated: No (Liver Safe)
  • Anabolic/Androgenic Ratio: N/A
  • Common Dosages: 10mg to 30mg daily
  • Common Cycle Length: 1-3 Months
  • Dosing Frequency: 1-2 times daily (Once daily if ‘Cutting’ or ‘Recomping’, Twice daily if ‘Bulking’)
  • Dosage Timing: Before Bed (Before Breakfast as well if ‘Bulking’)
  • Taking on Empty Stomach/With Food: Empty Stomach (Optimally)
  • Sample Cycle: 10/10/10/10/20/20/20/20/30/30/30/30 (in mg/day) {3-Month Cycle}