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    Default Increase The Efficiency Of Anavar

    Researchers in Portugal have conducted a study on Oxandrolone’s metabolites when consumed with caffeine. The Portuguese researchers acting on behalf of a doping lab Laboratório de Análises de Dopagem consulted the literature.

    Caffeine has been studied before about its ability to increase the uptake of certain drugs, notably Paracetamol in this study. So they curiously questioned if this effect would be evident in Oxandrolone (Anavar) users.

    The Portuguese researchers gave 0.4mg of Oxandrolone to a subject who consumed three espressos per day. The caffeine content of one espresso is 64mg. For the next forty hours the subject was monitored for the amount of caffeine, Oxandrolone and the inactive Oxandrolone metabolite Epioxandrolone in their urine.





    The experiment was then repeated giving the subject a larger caffeine dosage of 300mg in pill form. The figure above shows that the amount of Oxandrolone and Epioxandrolone rose by a factor of 20 and 15 respectively making its effects more pronounced.

    The researchers concluded that their experiment may show that caffeine causes a considerable improvement in the uptake of Oxandrolone by the body. “Practically this means that similar concentrations/effects may be achieved using lower dosages”, they write. “Other anabolic steroids should also be investigated.”
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    Maybe this is what Matt Porter did lol

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    Another interesting read on anavar. Apparently caffeine and creatine dramatically enhance anavar effects.




    Anavar is a well known steroid used by the fitness and bodybuilding community, but there are a few aspects that*make Anavar a truly unique and special Anabolic steroid.


    Oxandrolone is an orally modified version of Dihydrotestosterone (DHT) its* C 17 Alpha-Alkylated steroid, that means it has been refined and altered to survive the first pass through the liver so it assimilated very quickly and becomes active right away.


    Anavar half life is around 9 hours, so splitting up the dosing is more important to get an even blood*level.


    Why does Anavar have distinct cutting properties.


    First, we need to remember that fat deactivates DHT and it causes DHT's conversion into*5alpha-androstane 3alpha,17beta-diol*and*5alpha-androstane 3beta,17beta-diol.*Even though in small amounts they can protect against high arterial cholesterol, they have*high affinity for the estrogen receptors. The more adipose tissue around the waist, the greater this conversion, more water retention and fat gain inssues.


    Anti-estrogens cant help with this because their mechanism for action do not prevent DHT's conversion into these hormones. Anavar has a unique way of reducing adipose tissue.


    Anavar up-regulates the AR (androgen receptor) and also antagonizes the catabolic actions of cortisol. Cortisol, as we saw in my last article, slows down lipolysis, and decreases free test. Coupled with an up-regulated androgen receptor, less estrogen is able to bind.


    Anavar does not easily convert to DHT and so it doesn't get affected the same way DHT does by adipose tissue, This allows Anavar to be able to take effect, unhindered by deactivation or conversion.


    Whats important here, is that the AR gene has different effects in every individual, The AR gene provides instructions for making a protein called an androgen receptor. The AR gene, a DNA segment known as CAG is repeated multiple times, In most people, the number of CAG repeats in the AR gene ranges from fewer than 10 to about 36.


    Everyone has varying degrees of what is called Androgen Insensitivity Syndrome,


    And there are over 600 different degrees of mutation, causing*a* weakness towards Androgenic alopecia, or even prostate cancer.


    Since Anavar upregulates the AR gene, and the Androgen receptor, if you are genetically predisposed towards Prostate cancers, or Androgenic Alopecia, your more likely to speed up that process, despite it being mildly androgenic itself. Along with that principle comes its unique effect on fat cells. The increased sensitivity of androgen receptors causes more nutrients to be directed towards muscle cells and away from fat cells. It cannot be deactivated by fat cells as we have already seen, and its able to cause lipolysis, the breakdown of triglycerides into Glycerol and Fatty acids. Anavar Activates a very important enzyme called Hormone Sensitive Lipase (HSL) and this triggers Noradrenalin and Cyclic Adenosine Monophosphate into action.


    After Anavar is taken, and its active in the system, its up regulation on the androgen receptor and its ability to cause Noradrenalin to bind to adrenoreceptors in fat cells, then*Guanine nucleotide proteins cause the enzyme Adenylate cyclase to convert ATP into cAMP. (This is why creatine and Anavar work so well together as creatine increases muscle ATP)


    cAMP then binds to the protein kinase A,*then protein kinase A release its*catalytic subunit, This subunit phosphorylates (HSL*) it then becomes an active enzyme, called HSL-P, Then finally a 3 step action catalytic action takes place wich causes the breakdown of tryglycerides, they are then released into the blood system and excreted.


    The body tries to prevent fat breakdown via the negative feedback loop. One way it does this with Anavar is to try and prevent the accumulation of cAMP within cells. Caffeine can be used to prevent this by inhibiting phosphodiesterases within the cell. It also can prevent the actions of adenosine, which make it very useful when used along side Anavar at a dose of 60mg-90 mg, pre workout.


    Anavar dosing is entirely dependent on the size of the individual and their goals. Anavar is a much stronger anabolic than many believe, and its affects on fat loss seem to last, as it seems to have the ability to re-set Homeostatis, and allow for much lower bodyfat levels. The reasoning for this is its molecules can be contained within the fat cell for long periods, preventing the re-uptake of fat, which causes noradrenalin to stay bound the the receptor.


    Why does anavar cause muscle hardening


    Even though it is mildly androgenic, Anavar causes up regulation of the androgen receptor, causing the muscle to take on a much harder appearance. The nitrogen retention that Anavar causes, makes it highly anti-catabolic, so muscle recovery is increased which not only increases its activation of certain enzymes that burns adipose tissue as well as targeting fat that is in and around muscle bellies. This can strip away fat, as well as reveal cuts and striations within the muscle. The increased vascularity it causes has to do with there being less fat, increased nitrogen retention, and increased blood cell count. This also causes dramatic increases in endurance as well as strength.


    Using Creatine with Anavar is important since Anavar causes ATP to be reduced in its method of burning fat. It also has the ability to store creatine to a much greater level so consuming creatine along with Anavar will cause far greater strength increases and fat loss.


    As fat is broken down, and nutrients are forced into the muscle, think of the Androgen receptor being like a vacuum. It causes nutrients to be sucked into the muscles, and away from estrogen receptors. Anavar is also a very potent nutrient repartioner.


    All in all Anavar is one of the safest, mildest, but most effective tools for getting that beautiful physique you have dreamed of. Coupled with the right nutrition and training, its results can be nothing short of dramatic. Just use caution and make sure you have the right PCT and liver protection on hand.


    www.TheSupplementOutlet.com has top quality creatine


    CREATINE MONOHYDRATE
    <---- HERE


    PRO MAKER™ PERFORMANCE - 5 CREATINE BLEND<---------HERE
    Last edited by Cyber-Suppz; 06-26-2017 at 10:54 PM.
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    cyber-suppz Board Certified Psy.D

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    Great information on anavar.

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    I knew this and forgot completely lmao. But my prewo had both caffeine and creatine haha so i did so regardless haha.
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    Quote Originally Posted by guardianactual View Post
    I knew this and forgot completely lmao. But my prewo had both caffeine and creatine haha so i did so regardless haha.
    caffeine is good to know, but come on creatine........... are you pulling my leg?? Creatine by itself is awesome, but what legit research has been done on Var and creatine.

    That is like saying Var and Tren are synergistic.................tren by itself is so powerfull who could even tell??
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    I have always used Var in my cutting cycle. My strength jumps are noticeable, I'm clearly harder, and it definitely helps in fat loss. I drink a cup of coffee and take a pre wkout which has caffeine so I must be getting a bump that I wasn't aware of. I'd be reluctant to add in Creatine for 2 reasons. The first is that it makes you retain water which is counter productive to cutting. The second is due to the added stress puts on your kidneys.


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    Great information.
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