Thanks Thanks:  0
Recommend Recommend:  0
  1. #1
    Musclechemistry Board Certified Member Board Certified MD
    drtbear1967's Avatar
    Join Date
    Aug 2016
    Location
    Kentucky
    Posts
    5,663
    Rep Power
    2147489318

    Default Sobetirome AKA GC-1

    As most of you guys know, thyroid hormone regulates the metabolism of proteins, fats, and carbs and affects body composition. It determines how "lean" you stay year around(we all have that one friend that eats way more than you and still has abs 24/7.

    Sobetirome aka GC-1 is a thyroid hormone receptor(TRbeta) agonist "thyromimetic" (mimics thyroid hormone without being a hormone) that shows some very promising results in the way of fat loss, body comp, ect. Basically, GC-1 acts similarly as T3(thyroid hormone) in the body, but doesn't seem to cause suppression of TSH(thyroid stimulating hormone) levels, a side effect of supplementing with T3/T4/T2. What the studies have shown so far is that GC-1 can increase basal metabolic rate(and fat burning) without causing tachycardia, a side effect from T3. When compared head to head, T3 caused a slightly greater reduction in body weight vs GC-1, but both caused significant increases in energy expenditure and fat loss, while preventing fat mass accumulation. Another benefit noticed with GC-1 was the sparing of bone mineral density, something that is reduced when taking T3. GC-1 recently has been shown to help turn white fat into brown fat. Brown fat is high in UCP-1, a protein that upregulates fat burning via uncoupling. The latest study in mice showed a 50% loss in fat mass in just 2 weeks, as well as a 6-fold improvement in insulin sensitivity.

    GC-1 (Sobetirome) is currently in Phase 1a clinical trials for its cholesterol lowering effects. More research is needed, but this definitely looks promising and should hit the bodybuilding circuits soon, if it hasn't already.
    Get It Done!

  2. #2
    Presser's Avatar
    Join Date
    May 2002
    Posts
    41,683
    Rep Power
    2147525352

    Default

    GC-1 is new to me, but i do see it has gotten a lot more popular since this article was posted. Anyone seen or used it?
    Sobetirome AKA GC-1

  3. #3
    Musclechemistry Board Certified Member Board Certified MD
    drtbear1967's Avatar
    Join Date
    Aug 2016
    Location
    Kentucky
    Posts
    5,663
    Rep Power
    2147489318

    Default

    I would like to try it, if I could find it. Been busy and not able to do my research.
    Get It Done!

  4. #4
    MuscleChemistry Newbie Residency Training

    Join Date
    Oct 2003
    Age
    52
    Posts
    2
    Rep Power
    0

    Default

    Quote Originally Posted by drtbear1967 View Post
    I would like to try it, if I could find it. Been busy and not able to do my research.

    GC-1 (SOBETIROME) – AMINOASYLUM
    Likes drtbear1967 liked this post
     

Tags for this Thread

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  

Log in

Log in