drtbear1967
Musclechemistry Board Certified Member
A study just came out and yields some interesting data in mice about America’s favorite sugar additive: high-fructose corn syrup. Essentially, they used mice genetically predisposed to grow tumors in the intestines(and colon) and then either had them drink water with low concentration of HFCS or a high concentration.
The high HFCS group yielded significantly higher tumors >3mm, as well as high grade tumors(>40% grade). These results are independent of obesity or metabolic syndrome. HFCS is a mix of 55:45 glucose:fructose and can interfere with normal glucose and fructose uptake in the small intestine, in as little as 5g. The researchers cited that using radio labeled 14Carbon, the fructose was indeed taken up by the tumors in the colon.
Fructose also is converted into fructose-1-phosphate, which can cause a decrease in ATP production. Fructose also needs an enzyme fructokinase(HFK) to convert to glucose, which was upregualted in all the tumors. This is an extremely long and thorough study and some is out of the scope of this post, but the takeaway is to stay away from HFCS as much as possible, as it can interfere with normal glucose and fructose metabolism, ATP synthesis and has been linked to intestinal tumor growth via increasing glycolysis and de novo lipogenesis in mice. More research is needed in humans.
The high HFCS group yielded significantly higher tumors >3mm, as well as high grade tumors(>40% grade). These results are independent of obesity or metabolic syndrome. HFCS is a mix of 55:45 glucose:fructose and can interfere with normal glucose and fructose uptake in the small intestine, in as little as 5g. The researchers cited that using radio labeled 14Carbon, the fructose was indeed taken up by the tumors in the colon.
Fructose also is converted into fructose-1-phosphate, which can cause a decrease in ATP production. Fructose also needs an enzyme fructokinase(HFK) to convert to glucose, which was upregualted in all the tumors. This is an extremely long and thorough study and some is out of the scope of this post, but the takeaway is to stay away from HFCS as much as possible, as it can interfere with normal glucose and fructose metabolism, ATP synthesis and has been linked to intestinal tumor growth via increasing glycolysis and de novo lipogenesis in mice. More research is needed in humans.
