Fructose-containing sugars are known to be a target target for their putative role in causing obesity and cardiometabolic disease. However, current studies to support this claim are limited.
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Evidence from systematic reviews and meta-analyses of controlled trials has not shown that fructose-containing sugars behave any differently from other forms of digestible carbohydrates

Results show an association between fructose-containing sugars and cardiometabolic risk including weight gain, cardiovascular disease outcomes and diabetes only when restricted to sugar-sweetened beverages and not for sugars from other sources.
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The harmful effect from sugar-sweetened beverages is likely driven by a collinearity with an unhealthy lifestyle.

In summary fructose-containing sugars can only lead to weight gain and other unintended harms on cardiometabolic risk factors insofar as the excess calories they provide.
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This study has not found a that fructose-containing sugars behave any differently from other forms of digestible carbohydrates.