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    Default Flex Wheeler and the Myostatin Gene - rarest form of myostatin mutation

    Originally Posted by BALCO Laboratories, Inc.
    October 1, 1998

    Re: Flex Wheeler

    To whom it may concern:

    I am writing this letter per the request of Flex Wheeler.

    I would first like to briefly provide you with some background information regarding BALCO Laboratories. BALCO has been working with elite Olympic and professional athletes for over fifteen years. BALCO has provided testing and consultation for over 250 NFL players including the entire 1998 Super Bowl Champion Denver Broncos team and the entire Miami Dolphins team. BALCO works with professional athletes in many sports including teenis (Michael Chang, Jim Courier, etc.), hockey, bodybuilding (10 of the 16 1998 Mr. Olympia contestants), track and field, soccer and basketball (Seattle SuperSonics).

    BALCO Laboratories has been testing and monitoring Flex on a routine basis during the last year. We have performed tests including blood chemistry (SMAC), complete blood count (CBC), PSA, anabolic hormone levels, genotyping as well as comprehensive testing for nutritional elements. Flex's test results have been compared to twenty-four other professional bodybuilders and overall he has one of the healthiest profiles. Basically, Flex is in excellent health and has demonstrated the discipline necessary to maintain a peak level of conditioning.

    Flex was a participant in a study we recently conducted in collaboration with the Department of Human Genetics at the University of Pittsburgh involving 62 men who made unusually large gains in muscle mass in response to strength training (extreme responders). Flex was one of only nine extreme responders that had the very rare "myostatin mutation." Myostatin is the gene that "limits muscle growth." Specifically, Flex had the rarest form of myostatin mutation at the "exon 2" position on the gene. This simply means Flex has a much larger number of muscle fibers compared to the other subjects or the normal population. We believe that these are the very first myostatin mutation findings in humans and the results of this landmark study have already been submitted for publication. Flex was also found to have a very unusual type of the IGF-1 gene. In fact, Flex was the only participant in the study that did not have a "match." All of the other extreme responders had at least three other subjects with a matching IGF-1 gene. Based upon Flex's very unique genetic profile, we plan to expeditiously publish a scientific paper that reveals his complete genotype in specific detail. The publication of his remarkable genetic data should generate an enormous amount of media exposure.

    Hope this information will be helpful and please call if I can be of assistance.

    Sincerely,

    /s/ Victor Conte
    Victor Conte
    President
    BALCO Laboratories, Inc.

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    I found this pretty interesting...

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    I remember reading that a few years ago. Frankly, given the source and the subject, I don't buy it. Now if we were talking Ronnie Coleman.... OK, but Flex never blew me away. I also met Flex and spoke with at length at the 2006 Olympia. I was bigger than he was.... doesn't sound like muscle mutant of the century to me.
    The Dude Abides

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    pretty interesting none the less
    Author: Ben Presser
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    saudades
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    I remember hearing about that before. Lucky bastard.
     

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    I see a door for some type of "flex" supps. LOL. Explains alot. I bet several other pros would show the same genetic tendancies however. Its just like mma guys like Randy Couture who has been shown to have lower lactic acid after strenous exercise. In my opinion it just shows they are doing what they were created to do.
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    Is a fictitious character who talks about interesting topics just for fun. If your arms are 12 inches...don't shave them.

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    ...
    Last edited by Chris-Winfield; 12-07-2009 at 08:36 PM.
     

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    Stands out pretty good to me. I always thought Flex made bodybuilding look easy and NEVER tried as hard as the other guys. He looks amazing to me, very small joints and a small waist. He never had the huge gut Ronnie had. He always impressed me.

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    Wish I could look like that...
     

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    He was always one of my favorites. Very aesthetic looks.
    Bigger, Faster, Stronger

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    ...
    Last edited by Chris-Winfield; 12-07-2009 at 08:36 PM.
     

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    Forget a bout Flex.....Where can we get the myostatin???? lol
    There is no space for the littles!!!!!!!
    Bigheinz
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    Quote Originally Posted by bigheinz View Post
    Forget a bout Flex.....Where can we get the myostatin???? lol
    AAApeptides.com thats where!
    Last edited by Presser; 02-11-2016 at 11:20 AM.
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    very interesting, sure wish i had a myostatin mutation problem lmao
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    One hellof problem
     

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    yeah i want this rare myostatin gene problem lol, please !!

    gotta love BALCO labs and victor conte though lol,
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    does anyone know of any other gifted athletes who also have this Myostatin gene mutation that allows them to grow past normal shut off ranges?

    Its pretty amazing and i would venture to guess some professional bodybuilders and some other athletes likely have their myostatin gene mutated
    Author: Ben Presser
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    Damn Flex looks good in that photo above.
     

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    This might be the Best Bodybuilding Physique Of All Time! I mean just look at the perfection, minus the missing nut sack, lol, but hey mine is long gone to lol


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    Double allele mutation that causes natural inhibition of myostatin. I have seen it in bulls.
     

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    Lee Priest Talking about Flex Wheeler, but forward to 1:17 mark of the video Tell me what you think lol, Lee Says he took 2ml of winstrol eod , some clenbuterol and cytomel for his show and thats it lmao, curious, if what he meant was like just the last couple weeks out or month out, as i could see that, considering he always had to lose a lot of bulk to get into show shape, so i am wondering if meant just to prep precontest he used those 3 things, winstrol to spare muscle while dieting hard with clen and t3. Your thoughts?

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    Quote Originally Posted by Dean Destructo View Post
    Double allele mutation that causes natural inhibition of myostatin. I have seen it in bulls.
    Author: Ben Presser
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    They have problems though. Myostatin plays a big role in tendon repair IIRC. Also bulls like that are never healthy, it is not something you particularly want.
    I remember a huge forum about myostatin inhibitors on MM forum a decade ago and the final conclusion was it is not a good idea to take a myostatin inhibitor.

    I would theorize that Flex only has a ONE allele mutation, with just one myostatin gene shut off it would still be a major advantage.

    I know for myself I have a gene combination that makes me predominately fast twitch, and also I clear blood sugar very quickly. Downside is it can clear too quickly.
     

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    I have the R577X variant in the ACTN3 gene.

    The gene variant we looked at, called R577X, leads to a lack of functional alpha-actinin-3 protein. People with one copy of the variant only make some of this protein, while people with two copies don't make any.

    The alpha-actinin-3 protein is only found in certain types of fast-twitch muscle fibers. Less of this protein is associated with lower power output, which may help explain why few elite sprinters and power athletes lack this protein.

    The variant is rare in people of African ancestry, and is most common in people of Native American ancestry. Some researchers think that lacking alpha-actinin-3 was actually an advantage to early peoples in the Americas.
    ----------------------------------------------------------------------------------------------------------
    This makes sense since I am 1/16 Cherokee and also Choctaw (officially by blood record)
    Last edited by Dean Destructo; 08-17-2016 at 01:41 PM.
     

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    interesting, wish i had some gene mutations lmao
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    Quote Originally Posted by Presser View Post
    interesting, wish i had some gene mutations lmao
    You do, it is just a matter of which variant. When it all comes down to it we are just animals.
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