Testosterone replacement therapy: Which is best?

Date: April 27, 2015
Source: American Physiological Society (APS)
Summary: Intramuscular injection of testerosterone replacement therapy confers greater health benefits and lower cardiovascular risks than transdermal administration by skin patch or gel, a new study concludes.

--FULL STORY--
Use of testosterone replacement therapy (TRT) to treat age-related testosterone deficiency has tripled over the past decade in the U.S., but its benefits remain controversial.

A new review article by testosterone researchers at the University of Florida compared the modes of delivery and concluded that intramuscular injection of TRT conferred greater health benefits and lower cardiovascular risks than transdermal administration by skin patch or gel.

The article "Injection of Testosterone May Be Safer and More Effective than Transdermal Administration for Combatting Loss of Muscle and Bone in Older Men" is published ahead of print in the American Journal of Physiology -- Endocrinology and Metabolism.

Story Source:
The above post is reprinted from materials provided by American Physiological Society (APS). Note: Materials may be edited for content and length.

Journal Reference:
Stephen E Borst, Joshua F Yarrow. Injection of Testosterone May be Safer and More effective than Transdermal Administration for combating Loss of Muscle and Bone in Older Men. American Journal of Physiology - Endocrinology And Metabolism, 2015; ajpendo.00111.2015 DOI: 10.1152/ajpendo.00111.2015

Cite This Page:
American Physiological Society (APS). "Testosterone replacement therapy: Which is best?." ScienceDaily. ScienceDaily, 27 April 2015. <www.sciencedaily.com/releases/2015/04/150427182730.htm>

Some folks are getting good results with sub-q protocol.

sub q is the way to go if you have the patience. the E related sides are vastly diministed.

The one problem is when you are sub 10% BF, it leaves a visible lump. You have to switch to the love handles.

yellow snow said:

sub q is the way to go if you have the patience. the E related sides are vastly diministed.

The one problem is when you are sub 10% BF, it leaves a visible lump. You have to switch to the love handles.

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Yeah, but how is someone going to do 3-6 cc a week in a slin pin?

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Stickler* said:

Yeah, but how is someone going to do 3-6 cc a week in a slin pin?

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This is for TRT purposes only 1/2cc 2xs a week.

On a side note there is some pip doing this route, but it seems to aliveate the spikes

not sure i would ever try this

Presser said:

not sure i would ever try this

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Put it this way, if you are usind TRT for real TRT not to get legal T and run it high. Sub q is the way to go.

yeah i run my own special kind of TRT lmao,

I tried shifting my TRT from IM to SubQ (saw some doctor who is also on TRT do it in a youtube vid). I did not like it as much. I gave it a few weeks, but I did not feel as good as I did with IM so I moved back. Cannot put my finger on exactly what I liked more about IM, though. I just feel better when I pin that way.

I don't think I'd ever do my TRT subQ.

Now that they've shown there are cardiovascular risks associated with the transdermal delivery methods, I'll never let my doc give me anything but injectable.

cybrsage said:

I tried shifting my TRT from IM to SubQ (saw some doctor who is also on TRT do it in a youtube vid). I did not like it as much. I gave it a few weeks, but I did not feel as good as I did with IM so I moved back. Cannot put my finger on exactly what I liked more about IM, though. I just feel better when I pin that way.

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You have to stay wiht this approach for al least 4 weeks. The first two weeks you try it, it feels like you are on nothing; because of the delay of the T getting into your system. IM curculates the product quickly sub q delays the curculation for some time. After 4 weeks it is great because of the lowered E responce. You could just do IM and nolv, but it seems to be a steadier stream sub q once you get to the 3-4 week mark.

For some reason, I cannot click Thanks or Like - I am sure it is this crappy PC I am temporarily on...

Anyway, thanks for the reply yellow. I am also taking proviron and deca - so since I need to inject the deca IM anyway (using it to aid with joint lubrication) I will just stick with it. The proviron does such a good job of preventing E2 creation that I do not need to take any AI while taking even 300mg a week, which is double my TRT dose.

You are most likely correct, I did not give it enough time.

ill just stick with im i have gotten lumps from sub-q b-12 and those are bad enough

Mountain_Man said:

ill just stick with im i have gotten lumps from sub-q b-12 and those are bad enough

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When you get really lean, I hate the lumps too. I switch to the love handles.

Once I am done with my cut (starts on Monday), I will give SubQ another try.

let us know how it goes cybrsage u are the man with all ur lab test going on brother

cybrsage said:

Once I am done with my cut (starts on Monday), I will give SubQ another try.

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remember that for 2-3 weeks it is going to feel like you are taking nothing.