drtbear1967
Musclechemistry Board Certified Member
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As you may know, testosterone and many other androgens can be converted in the body to DHT via the enzyme 5alpha reductase(5aR). This enzyme adds 2 hydrogen atoms across the double bond between carbons 4 and 5. However, trenbolone cannot be reduced by 5aR. Why not? It has a 4-5 double bond so in theory it should. The answer lies in the energy of the trenbolone. If you look at the structure(bottom) tren has 3 alternating double bonds, which in chemistry is called conjugation. Essentially the electrons in these bonds are all connected and it lowers the overall energy of the molecule, which is very important for stability. To break this conjugation by reducing one of the double bonds costs more energy than the cost of staying conjugated. In other words, there is an energy barrier that 5aR cannot overcome bc of the electron system. If fact, the electrons on both oxygen atoms in the molecule also contribute to the conjugation and lower the overall energy of tren even more. This also creates a large dipole(direction of electron density) in the molecule which is why it binds so tightly to the AR and is very effective at low doses. This conjugation also prevents conversion to estrogen. I know this is science heavy, but this is how chemists go about understanding and synthesizing new androgens, like THG by Patrick Arnold.
As you may know, testosterone and many other androgens can be converted in the body to DHT via the enzyme 5alpha reductase(5aR). This enzyme adds 2 hydrogen atoms across the double bond between carbons 4 and 5. However, trenbolone cannot be reduced by 5aR. Why not? It has a 4-5 double bond so in theory it should. The answer lies in the energy of the trenbolone. If you look at the structure(bottom) tren has 3 alternating double bonds, which in chemistry is called conjugation. Essentially the electrons in these bonds are all connected and it lowers the overall energy of the molecule, which is very important for stability. To break this conjugation by reducing one of the double bonds costs more energy than the cost of staying conjugated. In other words, there is an energy barrier that 5aR cannot overcome bc of the electron system. If fact, the electrons on both oxygen atoms in the molecule also contribute to the conjugation and lower the overall energy of tren even more. This also creates a large dipole(direction of electron density) in the molecule which is why it binds so tightly to the AR and is very effective at low doses. This conjugation also prevents conversion to estrogen. I know this is science heavy, but this is how chemists go about understanding and synthesizing new androgens, like THG by Patrick Arnold.
