Just compounded Spironolactone for topical hair loss solution... Any input?

[JonnyMie]

SAVE MY HAIR: Just compounded Spironolactone for topical hair loss solution

I'd welcome any input on my compounding and this protocol...

So a few days ago I compounded a Spironolactone Solution for part of my new "anti-shedding" hair loss protocal. I need to get a new hair trimmer so I can take photos with a consistant length. Right now all I have is too short to see the thinning or too long for my self esteem to handle lol.... but I intend to log the results fairly thoroughly especially if there's any interest. The purpose of this solution is to find something that worked as well as Finasteride (Propecia) but without the horrible side effects I refuse to ever risk again. Side effects aside, Propecia worked excellently in stopping and even restoring my hair loss. My hair loss is pretty mild right now and isolated to the back. It's unnoticable trimmed supper short but very noticable once it gets maybe 3/8" long

I should have called this thread "throwing the kitchen sink at my head" lol

My new protocol is, in this order every evening before bed and usually a lighter application in the morning:

1. micro-needling with a .05" roller
2. Retin-A 0.1% gel
3. Minoxidil (I'm using a 15% Minoxidil, 5% Azelaic Acid and .001% caffeine blend from Dualgen or my own 15% compounded blend)
4. My homemade Spiro Solution

I'll also be using Ketoconazole (Nizoral 2%) shampoo with this protocol

The solution I made is 80ml of solution made up of the following two active ingredients disolved first in about 4ml ethyl alcohol:

• 1800mg of Spironolactone (Aldactone) ground up in a mortar and pestle
• 30mg of Finasteride (See note below)

Then after the active ingredients dissolved in the alcohol, I added 75mL of a 50/50 blend of PPG and Emu oil, and then put it in an amber 4 oz dropper bottle.

The solution seperated some but the active ingredients look like they've held and are completely dissolved.

NOTE: The active ingredients seem to have held in the alcohol, but I'm going to work on finding a better compounding for the next batch
NOTE: The finasteride is a very tiny percentage of the solution, but I'll probably leave it out of the next batch I make since even applied topically finasteride can go systemic

I'll follow this post up with the research behind all of this.

 

[JonnyMie]

Still left to do is get some PH testing strips, because the stability of spironolactone is pH dependent. If I find out it's off from 4.5 it's easy to adjust with e.g. citric acid or lactic acid. I've heard of similar home brewed concoctions with Spiro starting to stink and this may be why, or maybe it quickly degrades in the drug store lotions most people mix it with ... Either way adjusting the PH should address that although it smells fine to me right now.


Reference:

Source: J Pharm Sci. 1991 Jun;80(6):551-3.
Preformulation studies of spironolactone: effect of pH, two buffer species, ionic strength, and temperature on stability.
Pramar Y, Gupta VD.
Department of Pharmaceutics, University of Houston, TX 77030.

"Using a stability-indicating HPLC assay method, the effect of pH, two buffer species (citrate and phosphate), ionic strength, and temperature on the stability of spironolactone in 20% solution of ethyl alcohol in water has been studied. The optimum pH of stability appears to be approximately 4.5. On increasing the buffer concentration, both species hastened the decomposition of spironolactone. The ionic strength did not affect the stability of the drug. The energy of activation has been estimated to be approximately 78.8 kJ/mol at pH 4.3. The un-ionized spironolactone is subject to general acid-base catalysis. The Kh and Koh values at 40 degrees C have been estimated to be 1.63 and 2.8 x 10(5) day-1, respectively. The HPO4(-2) ion had approximately 10 times more catalytic effect than the H2PO4(-1) ion. This data will be used to develop a stable oral liquid dosage form of the drug." PMID: 1941547

 

[JonnyMie]

About Spironolactone (Aldactone)

About Spironolactone (Aldactone):

Spironolactone taken orally is a "potassium sparing" diuretic (water pill) commonly used to remove surplus fluid from the body's bloodstream or tissues. It also acts as an aldosterone inhibitor (prevents salt retention) and can be used to treat high blood pressure, hypertension and in some cases advanced heart failure. As for its indications in hair, Spironolactone is known to be a well tolerated and effective antiandrogen. It is sometimes used to treat female pattern baldness and excessive facial hair (hirsutism) in women and occasionally men use it as an antiandrogen under close supervision by their doctors. Hirsutism is most often caused by increased production of male sex hormones also known as androgens. It is also affected by increased sensitivity to androgens in the hair follicles, and the secretory glands around the hair follicles, called sebaceous glands.

There are studies (See below) which suggest that topical spironolactone can act as an antiandrogen in human sebaceous glands, competing with DHT receptors and producing a decrease of labeled DHT. This means that topical spironolactone may slow down or stop hairloss by working as a DHT receptors blocker. Despite the fact that most doctors caution male patients against using Spironolactone orally for hairloss for fear of adverse reactions such as loss in sex drive, impotence, breast development., some have been experimenting with low dose Spironolactone with some success.

References:

• "Use of cyproterone acetate, finasteride, and spironolactone to treat idiopathic hirsutism." Lumachi F, Rondinone R., Department of Surgical and Gastroenterological Sciences, University of Padua, School of Medicine, Padova, Italy. [email protected] (Fertil Steril. 2003 Apr;79(4):942-6.)
  
  OBJECTIVE: To compare the effectiveness of cyproterone acetate, finasteride, and spironolactone in the treatment of idiopathic hirsutism. DESIGN: Prospective randomized clinical study. SETTING: University hospital. PATIENT(S): Forty-one women (median age, 21 years ) with idiopathic hirsutism who had requested to use an oral contraceptive. INTERVENTION(S): Patients were randomly assigned to receive cyproterone acetate (12.5 mg/d for the first 10 days of the cycle), finasteride (5 mg/d), or spironolactone (100 mg/d) for 12 months. Follow-up was done at the end of therapy. MAIN OUTCOME MEASURE(S): Ferriman-Gallwey score before treatment, at 6 and 12 months of treatment, and 1 year after the end of treatment, and androgenic profile before and after treatment. RESULT(S): At the end of therapy, the Ferriman-Gallwey score decreased by 38.9%, 38.6%, and 38.5% in patients who used cyproterone acetate, finasteride, and spironolactone, respectively. One year after therapy, the Ferriman-Gallwey score of patients who used spironolactone was significantly lower (6.74 +/- 1.41) than that of patients who used either cyproterone acetate (7.92 +/- 1.08), or finasteride (9.08 +/- 0.99). The androgenic profile did not change significantly during treatment. CONCLUSION(S): In patients with idiopathic hirsutism, the short-term results of treatment with cyproterone acetate, finasteride, and spironolactone are similar, but spironolactone is effective for a longer time.​
• "Efficacy and tolerability of finasteride 1 mg in men aged 41 to 60 years with male pattern hair loss." Whiting DA, Olsen EA, Savin R, Halper L, Rodgers A, Wang L, Hustad C, Palmisano J; Male Pattern Hair Loss Study Group. Dallas Associated Dermatologists, 3600 Gaston Avenue, #1051 LB76, TX 75246, USA. (Eur J Dermatol. 2003 Mar-Apr;13(2):150-60.)
  
  A 24-month double-blind, randomized, placebo-controlled, parallel-group, multicenter study of 424 men was conducted to determine the efficacy and tolerability of finasteride 1 mg on hair growth/loss in men aged 41 to 60 years with mild-to-moderate, predominantly vertex male pattern hair loss. Efficacy was evaluated by review of global photographs of the vertex scalp taken at baseline and at Months 6, 12, 18, and 24 and by patient self-assessments and investigator clinical assessments of change from baseline in hair growth/loss collected at Months 6, 12, 18, and 24. Safety analyses included assessment of clinical and laboratory adverse experiences, including sexual adverse experiences. Analysis of global photographic assessment data showed significant improvement in hair growth for men in the finasteride group compared with those taking placebo beginning at Month 6 (p < 0.001) and maintained through Month 24 (p < 0.001). Results of the patient self-assessment and investigator assessments were consistent with those from the global photographic assessment. Finasteride 1 mg improved scalp hair growth in men aged 41 to 60 years with predominantly vertex male pattern hair loss compared with results seen with placebo. Improvement was evident by 6 months of treatment and continued through 24 months. Treatment with finasteride 1 mg was generally well tolerated. PMID:12695131​
• http://www.hairsite.com/o-spironolactone.htm
• Berardesca E, Gabba P, Ucci G, Borroni G, Rabbiosi G., Department of Dermatology, University of Pavia, Italy.
  
  The interaction between spironolactone and dihydrotestosterone (DHT) receptors was evaluated with an autoradiographic technique. The inhibition of DHT receptors by spironolactone was found to be related to the decrease of tritiated DHT granules in the sebaceous glands of the treated site. 6 male patients affected by acne vulgaris entered the study. The acute study was performed by applying to 25 cm2 of the back a cream containing 5% spironolactone under occlusive dressing. The dosage of spironolactone applied was 4 mg/cm2 for 48 h. The long-term study was performed by applying the same amount to the entire back, without occlusion, twice daily for 1 month. Skin biopsies were taken at the end of the treatment, incubated with tritiated DHT and processed for autoradiography. Both the acute and the long-term study revealed a decrease of the autoradiographic granules in the treated site. This effect is related to the binding of spironolactone with dihydrotestosterone receptors in the sebaceous glands. Our study demonstrates that 5% topical spironolactone cream acts as an antiandrogen in human sebaceous glands, competing with DHT receptors and producing a decrease of labelled DHT. At the concentrations used the effect has been only local. No side-effects were recorded during both studies.​
• "Oral and Topical Spironolactone Therapies in Skin Androgenization", Messina et al, Panminerva Med 1990; 32:49-55.
  
  "The most important clinical studies using spironolactone as an antiandrogen drug either per os or topically are referred. Menstrual disturbances very often occur during SP treatments thus limiting its systemic use. As far as the topical use is concerned SP seems to be highly effective with absence of systemic effects. Local mild side effects were present in a small number of patients".​
• "Synergistic antiandrogenic effects of topical combinations of 5 alpha-reductase and androgen receptor inhibitors in the hamster sebaceous glands," Matias JR, Malloy VL, Orentreich N., Biomedical Research Station, Orentreich Foundation Inc., Cold Spring-on-Hudson, NY 10516 (J Invest Dermatol. 1988 Nov;91(5):429-33.)
  
  The androgenic action of dihydrotestosterone (DHT) is antagonized by agents that compete with testosterone for the 5 alpha-reductase enzyme and by agents that block the binding of DHT to its receptor. The topical synergistic effect of 5 alpha-reductase (5 alpha RI) and androgen receptor inhibitors (ARI) was determined by measurement of the sebaceous gland size (SGS) of the ventral ear skin of the intact, sexually mature male Syrian hamsters. Progesterone (P), a 5 alpha RI, and spironolactone (SL), an ARI, produced a dose responsive decrease in SGS at topical concentrations of 0.01% to 5.0%. At concentrations of 1, 3, and 5%, P and SL combinations produced neither an additive nor synergistic inhibition of SGS. At very low concentrations of up to 0.10%, neither P nor SL alone produced any effect on SGS. When combinations of these two steroids were applied at low concentrations, SGS decreased unilaterally to approximately 50%. This synergy occurred best at a P:SL ratio of 1:2. The lower effective concentrations of P may be explained by its greater percutaneous absorption. Synergy was also demonstrated at low concentrations with other antiandrogens: cyproterone acetate, canrenone, hydroxyflutamide, and N-N-diethyl-4-methyl-3-oxo-4-aza-5 alpha-androstane- 17 beta-carboxamide. The use of anti-androgen combinations at low concentrations is of value because of the decreased risk of systemic side effects while maintaining potent topical efficacy.​
• "Transdermal Penetration of Topical Drugs Used in the Treatment of Acne," Clinical Pharmacokinetics: 2003 - Volume 42 - Issue 14 - pp 1287-1304 (Transdermal Penetration of Topical Drugs Used in the Treatme... : Clinical Pharmacokinetics)
• "Topical Spironolactone Inhibits Dihydrotestosterone Receptors In Human Sebaceous Glands: An Autoradiographic Study In Subjects With Acne Vulgaris", Berardesca et al, Int J Tiss Reac X(2) 115-119 (1988).
• "Reversal of andro-genetic alopecia in a male. A spironolactone effect?" Bou-Abboud CF, Nemec F, Toffel F., Department of Internal Medicine, University Medical Center of Southern Nevada, University of Nevada School of Medicine.
• http://www.hairsite.com/hair-loss-info/spironolactone-aldactone.htm

 

[JonnyMie]

Emu Oil

Emu Oil:

Emu oil is derived from a bird found in Australia. Research has shown that emu oil can have positive effects on various kinds of skin disorders, including hair loss. According to clinical studies in Australia and the U.S, emu oil is an excellent anti-inflammatory agent that can rejuvenate skin cells and produce up to 80% in healthy hair growth. Specifically, emu oil can penetrate tissue cells faster and more effectively than most other mechanisms. The potential benefits of emu oil are numerous, it can be used to treat various kinds of hair conditions, arthritis, wrinkles, and other skin disorders such as Psoriasis and Eczema etc.

Emu oil is not commonly known in the U.S. While it has been used by many for combating hair loss in various parts of the world, FDA regulations in the U.S discourage anyone from marketing Emu oil for hair loss.

If you do a little searching you'll find a million Emu Oil studies, but here's some quick references:

• At Auburn University, clinical studies showed that Emu Oil can be used as a transdermal carier and is 20 times more effective at penetrating the stratum corneum, or "skin barrier," than mineral oil.
• At the Boston University Medical Center , Michael Holick and his research team confirmed numerous beneficial properties of Emu Oil, including the promotion and acceleration of skin cell regeneration and even the stimulation of hair growth.
• In 1994, Dr. Alexander Zemstov conducted a "double blind" study on the properties of Emu Oil and he concluded the following properties of Emu oil: highly penetrating, emulsifier, bacteriostatic, low irritation potential, and non-comedogenic.
• "Composition of Emu Oil: The Micro View (1997)" Dr. Leigh Hopkins, AEA Oil Standards Team (Research Leader).
  
  SUMMARY: When compared with human skin oil, the fatty acid composition of emu oil is found to be quite similar. In both types of oil, mono-unsaturated oleic acid is the most prevalent fatty acid, followed by palmitic acid, then linoleic acid, which is an EFA (essential fatty acid). This similarity may be one of the factors enabling emu oil to have such a positive action on human skin.​
• More and more companies are now conducting research using Emu oil, eg: Delta West Pharmaceuticals, Orion Laboratories, and even the American Cancer Institute where Emu Oil is being studied for its effects on the immune system and tumor biology at the cellular level.
• "Fatty Acid Analysis of Emu Oil. (AEA funded study, 1994)" Dr. Paul Smith, Dr. Margaret Craig-Schmidt, Amanda Brown at Auburn University.
  
  SUMMARY: Analysis of fatty acids in emu oil reveals that it contains approximately 70 % unsaturated fatty acids. The major fatty acid found in emu oil is oleic acid, which is mono- unsaturated and which comprises over 40 % of the total fatty acid content. Emu oil also contains both of the two essential fatty acids (EFA's) which are important to human health: 20 % linoleic, and 1 - 2 % alpha-linolenic acid.​
• Emu Oil: Comedogenicity Testing.] (Study done for E.R.I., 1993) Department of Dermatology, at University of Texas Medical School, Houston.
  
  SUMMARY: Testing using the rabbit ear histological assay, with emu oil in concentrations of 25 %, 75 % and 100 % shows that emu oil in concentrations of up to 100 % is non-comedogenic, i.e. it does not clog the pores of the skin.​
• "Moisturizing and Cosmetic Properties of Emu Oil: A Double Blind Study "(1994). Dr. Alexander Zemtsov, Indiana University School of Medicine: Dr. Monica Gaddis, Ball Memorial Hospital; and Dr. Victor Montalvo-Lugo, Ball Memorial Hospital.
  
  SUMMARY: Eleven human subjects took part in a double-blind clinical study which compared emu oil with mineral oil in texture, skin permeability and moisturizing properties, as well as comedogenicity and irritability to the skin. No irritation to the skin was observed with either oil. However, comedogenicity of emu oil was significantly lower than that of mineral oil, and all subjects stated a unanimous preference for emu oil.​
• "Experimental Study to Determine the Anti-Arthritic Activity of a New Emu Oil Formulation (EMMP)" (1993) Dr. Peter Ghosh at Royal North Shore Hospital of Sydney, Australia and Dr. Michael Whitehouse at University of Adelaide, Australia.
  
  SUMMARY: A combination of emu oil with a suitable transdermal transporter is found to show anti-inflammatory (anti-rheumatic) activity in various rat models.​
• Research conducted at the Occupational Dermatology Laboratory of the University of Texas Medical School at Houston concluded that emu oil consists mostly of oleic acid, a mono-unsaturated fatty acid. The oil is highly penetrating and won't clog pores. It can help people whose skin is parched, cracked and has lost its smooth, healthy look. Beauty professionals across the country are touting the benefits of emu oil. Found in numerous cosmetics, soaps and shampoos, it has been reported that the oil also thickens aged, mature skin, making it appear younger. One study reported that 100 percent emu oil rubbed into the skin twice daily would thicken the skin by 14 percent.

With its all natural healing properties, emu oil would make an essential adjunct to any topical hair loss regimen. Emu oil in combination with topical minoxidil (eg: Rogaine 5%) could be very benificial. First, emu oil's anti-inflammatory properties will eliminate many side effects related to long term use of topical minoxidil. Most topical minoxidil solutions are alcohol based. While alcohol is one of the most effective solvent in the world, it is known to be a very dehydrating agent and can cause tissue damage in some cases. Many people have complained about severe itch, flakes, dryness, and other scalp irritaions due to long term use of topical minoxidil. Some people called these minoxidil induced irritations "minoxidil burn". Using emu oil in combination with topical minoxidil would seem to be an excellent idea in combating minoxidil's side effects. Second, as mentioned in the clinical study conducted at Auburn University, emu oil is 20 times more effective as a transdermal carrier than mineral oil. If used in conjunction with topical minoxidil, emu oil is very likely to enhance the penetration of minoxidil into the follicles. This will probably be better than using Minoxidil-Retin-A treatment since emu oil will probably increase minoxidil absorption without producing the same side effects as Retin-A.

 

[JonnyMie]

Retin-A (Tretinoin)

Retin-A (Tretinoin):


Tretinoin is a kind of vitamin A derivatives. It is a kind of topical preparation commonly used to treat acne vulgaris, fine lines, age spots and other visible signs of ageing. Tretinoin when used in combination with topical minoxidil is also a well known treatment for hair loss in both men and women.

Tretinoin has been shown to enhance cell and vascular proliferation. It is commonly referred to as a great exfoliator for the skin. Technically speaking, it works by altering the follicular epithelium (the outer layer of skin) so that it doesn't keratinize (form a hard compact layer). Studies have shown that Retin-A alone can result in moderate hair growth in some patients. When used in conjunction with topical minoxidil, Retin-A seems to be able to enhance the penetration and absorption of minoxidil. This may have to do with the fact that by preventing keratinization, Retin-A decreases the protective barrier of the skin and makes it more able to absorb medications that are put in direct contact with the skin. According to Dr. Lewenberg, "Topical tretinoin appears to increase the beneficial effects of minoxidil, and it is thought that this is due to increased absorption of minoxidil through alteration of the stratum cornum barrier."

Also, one study showed a triple absorption of minoxidil with 0.05 Tretinoin as compared with the controlled group.

References:

• "Topical tretinoin for hair growth promotion." Bazzano GS, Terezakis N, and Galen W. J Am Acad Dermatol 15:880-883, 1986
  
  Topical all-trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia. After 1 year, the combination of topical tretinoin with 0.5% minoxidil resulted in terminal hair regrowth in 66% of the subjects studied. Tretinoin was shown to stimulate some hair regrowth in approximately 58% of the subjects studied. One female subject with pronounced alopecia for more than 20 years had regrowth of hair using only tretinoin for a period of 18 months. Tretinoin has been shown to promote and regulate cell proliferation and differentiation in the epithelium and may promote vascular proliferation. These factors are important for hair growth promotion. These preliminary results indicate that more work should be done on the role of retinoids in hair growth. The synergistic effect of retinoids in combination with a low concentration of minoxidil should also be further investigated.​
• "Influence of tretinoin on the percutaneous absorption of minoxidil from an aqueous topical solution." Ferry JJ, Forbes KK, LanderLugt JT and Szpunar GJ, Clin Pharmacol Ther 47:439-46, 1990
• "Treatment of alopecia with a minoxidil-tretinoin combination. Topical application: Use in conjunction with topical minoxidil simultaneously for hair indications." Lewenberg A. Adv Ther. 1991;8:190-198.
  
  Dr Adam Lewenberg treated 484 people with a mixture of topical minoxidil and tretinoin. After two years of treatment "cosmetically satisfying" results were obtained in about 90% of these people. In an article written by Dr Lewenberg about his studies, Dr Lewenberg noted the following: "Unlike Minoxidil which effects on the vertex of the scalp, the combination of Tretinoin and Minoxidil results in hair growth in all regions of the scalp."​
• Remox Study: The Author of this study wished to confirm the efficacy of ReMox(a combination Of Tretinoin and Minoxidil) as a stimulant for hair regrowth, increase in hair volume And tensile strength of individual hairs in cases of alopecia androgenetica(AGA).
  
  18 men between age of 20-45 with varying degrees of AGA participated in a double blinded study for a period of 12 months. Each subject was randomly assigned to either the ReMox group or to a newly developed over the counter medication.
  Neither the author Or the subjects knew the nature of the treatment they were receiving. Each client was seen monthly, the scalp was examined and hair counts were measured under 6 times magnification and photographs were taken .The results, after 12 months based on hair counts, objective reports by the participants and visual evaluation by both the author and subjects were consistent with expectations. There was an overall improvement of 96% in overall hair count, volume and tensile strength both in the temporal and vertex areas A surprising and unexpected result, was that, the new over the counter hair re growth medication was almost as effective as ReMox producing a 93% increase in hair count in both the temporal and vertex areas. .This may indicate a totally new approach to stimulation of hair re growth in individuals suffering from alopecia androgenetica.​
• "Retinoids: compounds important to hair growth." Terezakis NK, Bazzano GS. Dermatology Research Foundation, Los Angeles, California.
  
  Although the mechanisms of follicular regression in androgenetic alopecia are not fully understood, retinoids may be important in changing the status of regressing follicles. There are many reports documenting reversal of epithelial dysplastic changes with retinoids. Although none of the studies with retinoids have concentrated on the precise mechanisms of follicular growth (regression or regeneration), these limited observations, and our early studies suggest that further work should be done on the effect retinoids have on the hair follicle during the various growth and regression phases of the follicular life cycle in humans. We propose that certain retinoids increase the rate of hair growth, prolong the anagen phase of the hair cycle, play a role in converting vellus to terminal hairs, and act synergistically with minoxidil to produce more dense hair regrowth from regressing follicles than either compound alone. Larger controlled studies and better methods for assessing hair growth are necessary to support these early results. Other retinoids as well as certain minoxidil analogs should also be studied.​
• Treatments for androgenetic alopecia and alopecia areata: current options and future prospects. Meidan VM, Touitou E. Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
  
  Common disorders of the hair follicle which may heavily influence self esteem and self image. Androgenetic alopecia is caused by the heightened sensitivity of scalp follicles to dihydro- testosterone whereas alopecia areata is induced by an autoimmune reaction. Current drug treatment approaches include the use of regrowth stimulators such as topical minoxidil and oral finasteride for androgenetic alopecia, as well as topical minoxidil, dithranol (anthralin), corticosteroids, contact sensitisers, and psoralen plus ultraviolet A irradiation (PUVA) therapy for alopecia areata. Combination regimens are also proposed. However, extreme cases of either type of alopecia do not generally respond well to these existing treatments. For this reason, new therapeutic strategies are directed towards both improving the targeting of existing agents, as well as the development of novel hypertrichotic modalities.
  ​
• Retinol Produces Changes in Skin Similar to Those Produced By Retinoic Acid, But Without Irritation.
  
  Human skin increases the thickness of the epidermis, enhances expression of CRABP-II (cellular retinoic acid binding protein) and CRBP (cellular retinol binding protein), and causes accumulation of retinyl esters, but does not increase retinoic acid levels or cause erythema. ROL, vitamin A1, is the predominant retinoid in circulation. Clinically, topical application of RA has been used for many skin abnormalities, including acne and photodamaged skin, but its application produces mild erythema and stratum corneum peeling. A retinoid with activity similar to RA but without the local irritation would be of interest. In the U.S., ROL has been widely used in cosmetics and considered safe and is thought to be the prohormone of RA, in that RA is formed from ROL by a two-step enzymatic process. Thus, Kang and colleagues asked whether ROL could achieve RA-like effects in skin. They used a patch-test procedure that involved four days of occlusion after topical application of ROL and of RA. They found that ROL may be a good substitute for RA because it was much less erythemogenic than RA, produced epidermal hyperplasia, increased the expression of both cellular retinoic acid binding protein (CRABP-II) and cellular retinol binding protein (CRBP) mRNAs and proteins, and was actively metabolized and stored as retinyl ester, but did not result in significant accumulation of RA.​
• Retin-A is a prescription drug used for the treatment of several skin conditions.
  
  Retin-A is a prescription drug used for the treatment of several skin conditions. It is one of the most effective drugs in the treatment of acne. Clinical trials showed a side effect of some hair regrowth. Many doctors claim that when used in conjunction with Rogaine/Minoxidil, it increases the effectiveness over minoxidil alone 10% or more. One of the ways Retin-A works is by ensuring proper functioning of the sebaceous glands. The sebaceous glands produce sebum on the scalp. Sebum contains DHT which is then reabsorbed into the hair follicles to do further damage. Proper moderation of the sebaceous glands and their production of sebum can help control skin scalp DHT levels, preventing androgen related hair loss. Retin-A also functions to promote cell growth and ensure the proper functioning of other parts of skin cells.​

 

[JonnyMie]

Ketoconazole (Nizoral 2%)

I'll try to expound on this one more at some future date but for now:

HAIR LOSS KETOCONAZOLE, NIZORAL, ANTI FUNGAL http://www.hairsite.com/hair-loss-info/ketoconazole.htm

About Ketoconazole: Ketoconazole is used to treat fungal infections. It binds to the fungal p450 enzymes and stops the cells making ergosterol, the main component of the cell wall. With its high affinity for fungal cell membranes, Ketoconazole is currently the world's #1 prescribed ingredient for treating dandruff (an uninflamed form of seborrhoeic dermatitis) and is available under the brand name Nizoral. Ketoconazole is also used as a topical agent to treat other skin and scalp disorders such as ringworm, athlete's foot, fungal infections of the fingernails, toenails, etc.

Ketoconazole in pill form is used for systemic treatment of infection. Oral ketoconazole is less often prescribed than in past years, because the newer drugs, such as itraconazole and fluconazole that are less likely to upset liver function.

According to Science Daily, ketoconazole also function as a weak antiandrogen. This compound can reduce levels of androgen from both the testicles and adrenal glands.

Brand Name: Nizoral.

Side effects: Ketoconazole is well tolerated when used in the shampoo preparations in accordance to the instructions. Most commonly reported side effects associated with ketoconazole based shampoos are dryness of the scalp and mild irritations. However, when used internally as a pill, ketoconazole can suppress hormone production, including testosterone, especially at high doses over a long time. Ketoconazole must be used cautiously if you have a history of liver disease. Hepatitis is the most dangerous side effect of this drug. Additive liver toxicity can occur if this drug is not used properly and with caution under the supervision of your doctor. Some people may experience nausea, vomiting, diarrhea, and headache while using this drug internally. Ketoconazole should not be taken with the antihistimine Seldane (also known as terfenadine) as they may lead to irregular hearbeats that could be fatal.

Topical application: Use topically as directed. No more than twice weekly.

 

[JonnyMie]

I'll leave the details of these 3 things for another time (if there's interest):

• Micro-needling
• PPG
• Minoxidil (Rogain)

 

[mcgaret]

what sides did you get from finistride. I used it for years and didnt notice any sides. I use dutistride now with a minoxidel compound.
Any loss is definitly slowed down. been using for years. (dutistride is oral and dont notice any sides - read it was more efective then
finistride.

 

[JonnyMie]

It completely shut my libido down after 6 months of use. It was sudden and extreme. Not a good experience! After reading more I found that some people (I think statistically it was around 1% don't quote me) haven't recovered 10 years after stopping use of Finasteride!! Fortunately shortly after stopping I was working again, but it almost ruined a relationship I had really wanted to work .... although maybe I should've stayed on and saved myself some trouble in the long run lol bitches be crazy.

There's a bunch of info on the side effects and associated law suites on finasteride. Durasturide, while I never tried it, is purported to have the same risks. It's just not worth it to me even to risk a lower dose. I'm usually pretty careful to do anything I can to mitigate side effects or at least understand them and accept the possible consequenses, and honestly I've never experienced any side effects from anything I wasnt prepared to accept until using Finateride. But there's no denying that for me it did work to halt and even reverse hair loss, so if I can find something (hopefully this Spiro) that works by a similar mechanism but doesn't go systemic I'm golden.

 

[jehdesai]

hey is ur home made spiro solution working ?
I have bought 25mg spiro tabs,glycerin and diluted 25% ethanol can you help me with a homogenous solution

 

[Presser]

hey is ur home made spiro solution working ?
I have bought 25mg spiro tabs,glycerin and diluted 25% ethanol can you help me with a homogenous solution

you might wanna start a new thread for your question bro so people see it and you can get more answers, as this is an old thread and you may not get too many people seeing it nor reading and answering ur question

 

[sunnykmr123]

Many physicians are resorting to aldosterone receptor blocker, such as spironolactone. This has given many people good results. It is kind of a water pill that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. I would recommend something like minoxidil as a much safer way to go. There are many other treatments like low level laser therapy, PRP therapy or Meso therapy that has shown very good results. You must evaluate them as well.

 

[unzMankewve]

welcome to my blog

Have you ever thought about adding a little bit more than just your articles? I mean, what you say is important and all. However just imagine if you added some great photos or videos to give your posts more, "pop"! Your content is excellent but with images and clips, this blog could certainly be one of the most beneficial in its niche. Superb blog!

 

[unzMankewve]

welcome to my blog

I am curious to find out what blog system you happen to be using? I'm experiencing some small security issues with my latest website and I'd like to find something more secure. Do you have any recommendations?

 

[Presser]

pretty solid read, took me a bit to get through, but overall very good information, and ive never heard of people shutting down permanently like this, although the reversing hairloss to the point of new hair growth sounds fucking awsome, but not at the risk of my cock lol, i use finesteride many times, never had any issues