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06-22-2005, 12:50 PM #1
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what are the side effect of IGF-1
i just wanted to know what the side effects of IGF-1 are from everything that i have read on this site it seems that everyone has had a good experience with it. and Im assuming that it is to be injected into the muscles your looking to improve is this correct because the whole powder thing kind threw me off. and does it have to be refrigerated? and one more question sorry to ask so many, is it legal ? Im asking because some where I read it was experimental.
thanks for your time
and by the way all the advice you guys have given has resulted in a loss of 7% body fat and a gain of 10 lbs over all. thankscybrsage liked this post
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06-23-2005, 12:47 PM #2
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06-23-2005, 01:38 PM #3
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Dude,
There are some bad side effects to almost everyhting people use in BBing. IGF-1 is no different, it's not as hard on the liver/kidneys as AAS but there are plenty of sides to worry about. Here's some info as an example (from https://www.pdrhealth.com/drug_info/n...s_0303.shtml):
Insulin-Like Growth Factor 1
(IGF-1)
DESCRIPTION
Insulin-like growth factor-1 (IGF-1) is a single-chain polypeptide of 70 amino acids. It is a trophic factor that circulates at high levels in the blood-stream and mediates many, if not most, of the effects of growth hormone. Although the main source of IGF-1 in the serum is the liver, many other tissues synthesize it and are sensitive to its trophic action. IGF-1 was called somatomedin in the older literature. IGF-1 and insulin have similar three-dimensional structures.
IGF-1 appears to influence neuronal structure and functions throughout the life span. It has been shown to have the ability to preserve nerve cell function and promote nerve growth in experimental studies. Because of these properties, recombinant human IGF-1 is in clinical trials for the treatment of amyotrophic lateral sclerosis (ALS).
Recently, recombinant human IGF-1 has entered the dietary supplement marketplace, as have recombinant human growth hormone and several so-called growth hormone secretagogues or releasers.
ACTIONS AND PHARMACOLOGY
ACTIONS
Supplemental IGF-1 has putative anabolic and lipolytic activities.
MECHANISM OF ACTION
The mechanism of the putative actions of supplemental IGF-1 is unknown.
PHARMACOKINETICS
Orally administered IGF-1 has very poor bioavailability. There is no credible evidence that IGF-1 is absorbed from the oral mucosa if administered as a spray. It is likely that orally administered IGF-1 is digested in the small intestine to the amino acids that comprise the molecule.
INDICATIONS AND USAGE
Claims for supplemental IGF-1 are sweeping and include antiaging, promotion of lean muscle mass, enhanced athletic and sexual performance, joint protection, antidiabetic and antiatherosclerotic effects, sleep aid, immune enhancer, neuroprotector and much more. There is no credible evidence to support these claims for oral IGF-1. High levels of IGF-1 have been associated with elevated risk of several cancers, especially prostate cancer.
RESEARCH SUMMARY
There is no research to support the use of IGF-1 as a nutritional supplement, whether in oral or injected form. There is research showing associations between high levels of circulating IGF-1 and several cancers.
Claims that IGF-1 supplements significantly increase lean muscle mass are unsubstantiated. Use of IGF-1 in doses far higher than those used by most bodybuilders failed to produce more than very modest anabolic effects in AIDS patients. It is possible that some clinical indications, but not supplemental indications, will emerge from experimental work currently underway with IGF-1. There is a hint in some of this work that IGF-1 might, for example, have some neuroprotective and neurorestorative effects in some conditions.
CONTRAINDICATIONS, PRECAUTIONS, ADVERSE REACTIONS
CONTRAINDICATIONS
Supplemental IGF-1 is contraindicated in those with any evidence of active malignancy. It is also contraindicated in those who are hypersensitive to any component of an IGF-1-containing product.
PRECAUTIONS
Pregnant women and nursing mothers should avoid the use of supplemental IGF-1-containing products.
Adolescents should avoid the use of supplemental IGF-1-containing products.
Supplemental IGF-1 is not meant to be used parenterally and should never be used in such a manner.
ADVERSE REACTIONS
None known for supplemental IGF-1-containing supplements.
INTERACTIONS
There are no known interactions for supplemental IGF-1-containing supplements.
OVERDOSAGE
No reports for supplemental IGF-1-containing supplements.
DOSAGE AND ADMINISTRATION
Supplemental IGF-1 is available and marketed as a dietary supplement, typically in the form of an oral spray. There are no recommended doses.
LITERATURE
Carro E, Nuņez A, Busiguina S, Torres-Aleman I. Circulating insulin-like growth factor 1 mediates effects of exercise on the brain. J Neurosci. 2000; 20:2926-2933.
Chan JM, Stampfer MJ, Giovanucci E, et al. Plasma insulin-like growth factor 1 and prostate cancer risk: a prospective study. Science. 1998; 279:563-566.
Giovannucci E, Pollak MN, Platz EA, et al. A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women. Cancer Epidemiol Biomarkers Prev. 2000; 9:345-349.
Hankinson SE, Willett WC, Colditz GA, et al. Circulating concentrations of insulin-like growth factor-1 and risk of breast cancer. Lancet. 1998; 351:1393-1396.
Le Roith D. Insulin-like growth factors. N Engl J Med. 1997; 336:633-640.
Lewis ME, Neff NT, Contreras PC, et al. Insulin-like growth factor-1: potential for treatment of motor neuronal disorders. Exp Neurol. 1993; 124:73-88.
Magee BA, Shooter GK, Wallace JC, Francis GL. Insulin-like growth factor 1 and its binding proteins: a study of the binding interface using B-domain analogues. Biochem. 1999; 38:15863-15870.
Mantzoros CS, Tzonou A, Signorello LB, et al. Insulin-like growth factor 1 in relation to prostate cancer and benign prostate hyperplasia. Brit J Cancer. 1997; 76:1115-1118.
Niblock MM, Brunso-Bechtold J, Riddle DR. Insulin-like growth factor 1 stimulates dendritic growth in primary somatosensory cortex. J Neurosci. 2000; 20:4165-4176.
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06-24-2005, 11:23 AM #4
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03-18-2016, 09:26 AM #5
IGF-1 Reported Side Effects are Enhanced Strength, Quality Lean Muscle Gains, That are your to keep! Anti-aging! Better Skin Elasticity! Collagen Synthesis which correlates directly to stronger tendons, and tendon healing as tendons are comprised of collagen , Better Steroid uptake by way of more receptors for say testosterone to attach to or whatever steroid your using at the time. Localized muscle growth where the igf-1 lr3 is applied.
and this one is from me, through my personal experience, and the reason i found igf-1 lr3 to begin with and first time i ever used it was for nerve damage, and it made a dead or damaged nerve start firing again after i had nerve damage in my quad, and the muscle was flacid for close to a year, until i found igf-1 lr3, before it was popular, and before it was being used for bodybuilding for the most part. Used in close proximity to the nerve damage my quad started to fire/flex again after doctors said it would never flex again, and it finally did after igf-1 usage! Though the quad muscle was small as hell as atrophy had set in from it being dead for a year, but today it is 100% normal, and the same size as my other quad!
IGF-1 Lr3 is simply amazing product! Period!
I know this post is old that i am updating, however it popped up on a google search and i wanted to update it since a lot of searchers are finding this thread on google!
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03-18-2016, 11:30 AM #6
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This one post has a lot of good info in it. Nice bump presser.
cybrsage liked this post
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03-19-2016, 10:07 AM #7
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Iv'e just started it for the first time and I've had no bad side effects to this point. My rats have reported that as soon as they are injected they feel really good and want to lift shit.
crackerd liked this post
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03-19-2016, 10:43 AM #8
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The sides aren't like the ones you'll experience from AAS such as mood swings, acne etc it's more of an internal issue. The problem is that we don't have long term research as of yet in the way of bodybuilding doses (50-200mcg a day) may effect organ growth etc. we know that if you have cancerous cells in your body they will grow faster but it certainly doesn't cause cancer. By all means use it as long as your wary of what it could potentially do. I love the stuff, as much as its great for muscle building purposes and pump etc I use it most for well being mainly sleep quality. If you use it be sure to buy from MC !
crackerd thanked for this postyellow snow liked this post
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03-19-2016, 11:19 AM #9
that is why is should go without saying (yet it does all the time). Get your blood work done on a regular basis; if you are getting your bloods done every 10-12 weeks the doctors will catch most things that we worry about in a very quick time frame. Most things, including cancer, can be treated in this day and age if caught quickly.
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11-25-2016, 09:15 AM #10
IGF-1 lr3 is no more cancer causing than steroids, HGH, and hell half the crazy designer steroids out there today!
I been on IGF-1 lr3 for about 15 or so years, rarely without a break, and can tell you first hand im healthy as a horse, lol
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12-04-2016, 11:37 AM #11
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12-04-2016, 12:50 PM #12
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12-04-2016, 01:58 PM #13
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12-04-2016, 03:32 PM #14
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Presser liked this post
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12-04-2016, 04:45 PM #15
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12-04-2016, 05:41 PM #16
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Iron Game liked this post
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12-04-2016, 11:29 PM #17
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12-04-2016, 11:32 PM #18
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12-05-2016, 07:43 AM #19
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12-05-2016, 04:55 PM #20
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Presser liked this post
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12-09-2016, 09:48 AM #21
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12-18-2016, 11:47 AM #22
SORRY , I just now seen this question, and Yes, although its systemic and will help build muscle and shuttle nutrients throughout the body, It has been my experience that Site Specific Muscles Will grow faster than everything else when used this way. I have also noticed that when I have used it SubCutaneously on my abs, that fat loss was more prevalent!
And yes that me in my avatar, thank you
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07-22-2020, 05:46 AM #23
Some solid igf-1 lr3 information to bump back to the top!
Hypertrophy
systemic
nutrient shuttling (hence insulin-like)
Burn fat for energy
IGF 1 lr3 Growth Factor Peptide Store