TB-500(Thymosin Beta 4)2mg
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</tbody>[h=1][/h]TB-500 offers many benefits to the equine world in performance racing. Recent trials by some of the world’s leading trainers on their prize winning equine members of both genders, have been credited by a huge boost in their race-day results, something long desired in the racing world.
These trials along with clinical trials have indicated the following benefits associated with the use of TB-500 on mares and stallions*:
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| What is TB500? |
TB-500 is a synthetic version of the naturally occurring peptide present in virtually all human and animal cells, Thymosin Beta 4 (TB500). It is a first-in-class drug candidate that promotes the following*:
This potent peptide is a member of a ubiquitous family of 16 related molecules with a high conservation of sequence and localization in most tissues and circulating cells in the body. TB500 not only binds to actin, but also blocks actin polymerization and is the actin-sequestering molecule in eukaryotic cells. TB500 was identified as a gene that was up-regulated four-to-six fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels. This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells. An additional key factor of TB500 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeleton. It has been demonstrated that a central small amino acid long-actin binding domain has both blood cell reproduction and wound healing characteristics. These characteristics are uncovered by accelerating the migration of endothelial cells and keratinocytes. It also increases the production of extracellular matrix-degrading enzymes. Research confirms that TB500 is a potent, naturally occurring wound repair factor with anti-inflammatory properties. TB500 is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight meaning it can travel relatively long distances through tissues. |
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These trials along with clinical trials have indicated the following benefits associated with the use of TB-500 on mares and stallions*:
- Increased muscle growth with huge increases in endurance and strength noted
- Relaxed muscle spasm
- Improved muscle tone
- Increases the exchange of substance between cells
- Encourages tissue repair
- Stretches connective tissue
- Helps maintain flexibility
- Reduces inflammation of tissue in joint
- Enhances nutritional components in the animal
- Prevents the formation of adhesions and fibrous bands in muscles, tendons and ligaments.
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