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    Default AAA Peptides MK-2866 (Ostarine) info

    As a research chemical,*Ostarine*belongs to a class of chemicals known as*SARMs*or*Selective Androgen Receptor Modulators.*SARMS*create selective anabolic activity at certain androgen receptors and not others, hence their name. Compared to*testosterone*and other anabolic steroids and pro hormones, the advantage ofSARMS*such as (Ostarine) MK-2688 is that they do not have androgenic activity in non-skeletal-muscle tissues.
    Ostarine*is effective in not only maintaining*lean body mass*(LBM) but actually increasing it.

    It is often described or named S1 on various interenet sources, however this is actually incorrect as S1 was aSARM*that was develped quite early and is no longer undergoing any further development.

    How does it work?

    Selective androgen receptor modulators*(SARMs) bind to the androgen receptor and demonstrate osteo (bone) and myo (muscular) anabolic activity.
    Androgen receptor activation

    Binding and activation of the Androgen receptor alters the expression of genes and increases protein synthesis, hence builds muscle.

    So in essence,*SARMS*such as*Ostarine*causes muscle growth in the same manner as steroids, however unliketestosterone*and other anabolic steroids andprohormones,*SARMS*(as nonsteroidal agents) don’t produce the growth effect on prostate and other secondary sexual organs.

    Ostarine*in particular exerts its anabolic effects on muscle tissue almost exclusively. So not only does it represent a new potential treatment option for a wide spectrum of conditions from*muscle wasting*diseases (from age-related to AIDS or cancer-related), but is also has immense potential for muscle building for Bodybuilders, fitness, athletes and an agent to minimize atrophy during recovery periods from serious surgery or similar situations.



    Evidence of*Ostarine’s Abilities?

    To date, GTx has evaluated*Ostarine*in eight clinical trials involving approximately 600 subjects including three efficacy studies. A four month Phase IIb clinical trial enrolled 159 patients with the study meeting its primary objective of an*absolute increase in total*lean body mass(muscle)*compared to placebo and the secondary objective of*muscle function (increase in strength).

    In particular application to bodybuilding, there have been many logs of users on various forums using*Ostarine*as an aid to increase lean body mass and strength levels.




    Uses of*Ostarine

    Lean muscle gains (bulking)



    As*Ostarine*is the most anabolic of the available*SARMS, its first and formost use must be when trying to gain lean muscle.
    Now the gains in absolute weight won’t be comparable to steroids such as diannabol, however what will be gained will almost exclusivley be lean mass. Due to the lack of shutdown in comparison to steroids/prohormones, a*PCTperiod is not needed and almost all the mass that is gained on*Ostarine*is kept once the*cycle*is finished.
    Doses of*25mg*for*4-6 weeks*are the most common protocol for such goals. Over this 4-6 week period will typically produce 6lbs or 3kg of lean, keepable gains. However the abundant side effects of steroids/ProHormones*will not be present.

    Users have as high as 36mg [only recommended for those who weigh in at 210lbs (95kg)+] for periods as long as 8 weeks. However the potential for suppression from such doses is higher and users would have to look into a*PCTprotocol after undergoing such a*cycle.
    As the majority of*Ostarine*supplies come in 30ml bottles at 25mg/ml, a dose of*17.5mg*per day will give the user a6 week*cycle*from one bottle, a very good compromise between an anabolic dose and cost.

    Losing Bodyfat (cutting)



    Ostarine*would primarily fit into a cutting protocol for the maintainance of muscle mass whilst reducing calories.
    One of the most disheartening outcomes of cutting is the loss hard earned muscle mass.
    The drop in metabolic rate and hormone levels (T3, IGF,Testosterone*etc) with the lack of calories is a perfect catabolic enviroment for loss of muscle tissue.
    As*Ostarine*has anabolic effects, the dieter can cut calories without having to worry about muscle or strength loss.
    Ostarine*has also shown noticeable nutrient partioining effects among users, another reason why it can be of great help when cutting.

    A*12.5-15mg*dosing protocol for 4-6 weeks is good for cutting with*Ostarine*without undergoing any side effects or suppression.
    However it must be stated that due to the lack of androgenicity, muscle hardness and overall results are not as prominenant as with the*SARM*S-4.

    Recomping (gaining muscle and losing bodyfat at the same time)


    Recomping*is where*Ostarine*really shines.
    The recomping effect of losing fat and gaining muscle at the same time is what the majority of users are looking for. Trying to achieve this when you are not absolutely new to training is extremely difficult.
    Where*Ostarine*shines for recomping is in its nutrient partioning benefits. Calories are taken from fat stores and calorie intake is fed to the muscle tissue. In fact many users report that*Ostarine*consumed at maintainace calories produces weight loss, whilst still getting increases in strength and muscle mass!

    One of the most important factors of recomping is TIME. As you are trying to achieve multiple objectives, it requires a longer time period to notice good recomp effects so even when running steroids, these would have to be longer run injectible compounds as oppose to the short used liver toxic oral steroids/ProHormones.

    Although*Ostarine*is taken orally, as it is not methylated it is not as liver toxic as other oral steroids/ProHormones. Therefore it can be run for longer than the standard 4 week period with the aforementioned compounds.

    The dosing protocol of*12.5-25mg for*4-8 weeks*will give excellent recomp effects.
    Diet must also be optimized to where calories are just above maintaninance with at least 30% coming from lean sources of protein to get the best recomp effect.

    Injury Prevention



    As mentioned by Furuya, the effects of MK-2688 translate to*anabolism*in bone as well as skeletal muscle tissue, which means it could be used in the future for a wide variety of uses such as*osteoporosis*and as a concurrent treatment with drugs that reduce bone density.
    Therefore it has great application as a compound to use for rehabilitation of injuries, in particular bone and tendon related injuries.

    Doses of 12.5mg per day is recommend for such purposes and improvement in joint movement that can be seen after just 6-8 days.
    Timing of Doses

    As*Ostarine*has a half life of around 24 hours, each of these doeses only has to be taken orally once a day, therefore its also offers an extremely convientinet supplementation intake.
    Ostarine*and estrogen concern

    SARMS*cannot be aromatized, conferring all their effects to AR binding and not to metabolic conversion to active androgens/estrogens.
    However blood work from users has shown a slight elevation in serum*estradiol*levels (which may be one of the factors in its high effectiveness for treating tendon, ligament, and bone injuries or illnesses.
    This elevation is extremely small and is no case for concern. If however you are absolutely concerned about slight increases in Estrogen, you can always opt for low doses of OTC aromatase inhibitor’s such as 6bromo or very very low doses of prescription aromatase inhibitor’s like*adex*or*aromasin.

    Advantages Of*Ostarine*when compared to Steroids/ProHormones

    There is no need for pre*cycle*supports such as Hawthorn berry.There is no need for on*cycle*supports such as milk thistle for the liver,*policosanol*or RYR for cholesterol etc.Some suppression may be present at doses of 25mg+ run for longer than 4 weeks, however a stringent*PCT*of prescription SERMs like*nolva*orClomid*is not necessary.High oral biovailabilty without significant damage to your liver as with oral steroids/ProHormonesGreat sense of well being while on, (without the aggression which can often detrimentally impact users daily lifes).No need for a long time period off between cycles; the recommended time of period for normal cycles would be Time on +PCT, so for a typical 6 weekcycle*and 4 week*PCT, a user would have to wait another 10 weeks after*PCT*to start another*cycleOstarine*(MK-2866) also resulted in a dose-dependent decrease in LDL and HDL cholesterol levels, with the average LDL/HDL ratio for all doses remaining in the low cardiovascular risk category – hence there is little impact on cholesterol values.
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