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    Default IGF-1 New study further proves IGF-1s vital role in muscle regeneration and repair

    Abstract  Skeletal muscle is a highly dynamic tissue that responds to endogenous and external stimuli, including alterations in mechanical loading and growth factors. In particular, the antigravity soleus muscle experiences significant muscle atrophy during disuse and extensive muscle damage upon reloading. Since insulin-like growth factor-1 (IGF-1) has been implicated as a central regulator of muscle repair and modulation of muscle size, we examined the effect of viral mediated overexpression of IGF-1 on the soleus muscle following hindlimb cast immobilization and upon reloading. Recombinant IGF-1cDNA virus was injected into one of the posterior hindlimbs of the mice, while the contralateral limb was injected with saline (control). At 20 weeks of age, both hindlimbs were immobilized for two weeks to induce muscle atrophy in the soleus and ankle plantar flexor muscle group. Subsequently, the mice were allowed to reambulate and muscle damage and recovery was monitored over a period of 2 to 21 days. The primary finding of this study was that IGF-1 overexpression attenuated reloading-induced muscle damage in the soleus muscle, and accelerated muscle regeneration and force recovery. Muscle T2 assessed by MRI, a nonspecific marker of muscle damage, was significantly lower in IGF-1 injected, compared to contralateral soleus muscles at 2 and 5 days reambulation (P<0.05).


    The reduced prevalence of muscle damage in IGF-1 injected soleus muscles was confirmed on histology, with a lower fraction area of abnormal muscle tissue in IGF-I injected muscles at 2 days reambulation (33.2±3.3%vs 54.1±3.6%, P<0.05). Evidence of the effect of IGF-1 on muscle regeneration included timely increases in the number of central nuclei (21% at 5 days reambulation), paired-box transcription factor 7 (36% at 5 days), embryonic myosin (37% at 10 days), and elevated MyoD mRNA (7-fold at 2 days) in IGF-1 injected limbs (P<0.05). These findings demonstrate a potential role of IGF-1 in protecting unloaded skeletal muscles from damage and accelerating muscle repair and regeneration.
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    good find bro
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    bumping solid studies
    Author: Ben Presser
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    Pretty good read. It's cool to see real scientific studies like this. Makes it even harder to deny the benefits.
     

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    Double bump!!!!
     

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    solid info to float back up for potential igf-1 lr3 customers
    Author: Ben Presser
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    another good igf-1 lr3 read!
    Author: Ben Presser
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    great igf-1 information
    Author: Ben Presser
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    I am loading up on igf 1 lr3 as we speak to my torn bicep region ! I really fucked the pooch this time in terms of fucking my bicep up! So yeah IGF-1 lr3 has saved me from serious Nerve damage in quad years ago to a full recovery and well, I am hoping it does the same thing now for my bicep
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    Author: Ben Presser
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    Great IGF 1 lr3 info, and as for my torn bicep, well there was no repairing it with surgery. So time to try growing the fucker so it dangles down over the area it tore from lmao
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    I have a buddy who has a "dead" muscle and igf is bringing it back............he is so excited and is very thankful that I shared the info with him since nothing else was working.
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    Quote Originally Posted by yellow snow View Post
    I have a buddy who has a "dead" muscle and igf is bringing it back............he is so excited and is very thankful that I shared the info with him since nothing else was working.
    That's awesome to hear! Definitely keep us updated on his progress.

    Sent from my SM-N950U using Tapatalk
     

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