1. #1
    Iron Game's Avatar
    Join Date
    Apr 2008
    Location
    MD
    Age
    51
    Posts
    5,060
    Rep Power
    2147488723

    Default ORAL GH ON THE WAY!! PED BREAKTHROUGH

    DRUGS IN SPORT BREAKTHROUGH - ORAL GH MAY BE COMING!

    Written by William Llewellyn






    Human growth hormone (somatropin) is among the more common non-steroid drugs used in bodybuilding and sport. It is a powerful growth mediator, essentially identical to the growth hormone circulating in our bodies at especially high levels when we are young. Pharmaceutical human growth hormone (hGH) is expensive, though, and not the most comfortable drug to use on top of it. It traditionally requires daily subcutaneous injections. Though some progress has been made with reducing injection frequency, we haven’t seen any major breakthroughs with novel delivery methods as of yet. That may soon change, however. According to a recent study in the Journal of Biomaterials Applications, researchers have succeeded in creating the first orally viable form of hGH.1 Oral hGH would, of course, be a game-changing technology.





    For a long time, many scientists were skeptical that such a route of administration would ever be possible. The reason is simple. Human growth hormone is a complex and fragile peptide (protein) made of 191 amino acids. These amino acids are present in a very particular sequence and arrangement (fold). The digestive process can be harsh, and very destructive to fragile proteins like this. Normally, you cannot expect to receive an appreciable amount of hGH in the blood by giving it to someone orally. The body will destroy it first. Overcoming this barrier is an exceedingly difficult challenge. If this research holds true, it would represent the single greatest achievement in this field since the development of recombinant technology, which is used to reproduce the hGH protein.





    How It Works


    The method the researchers used to produce an orally effective hGH, in this case, is twofold. First, they applied enteric coating on their hGH capsules. This is a fairly common technology these days, where the capsule will not open in the high-acid environment of the stomach. They only break open after they pass through to the small intestines (the ileum, specifically), where there is a significant increase in pH (reduced acidity). This alone would likely not yield an effective product, however. They also tried that for comparison, in fact. The digesting process continues to be destructive. In this case, the researchers also placed the fragile proteins into tiny nanoparticles. These nanoparticles were made of monomethoxyl poly(ethylene glycol)-b-poly(L-lactide-co-glycolide), also know as PEG-PLA. This is a nontoxic polymer increasingly used to aid drug delivery. These particles serve to further protect the protein from degradation, carrying it into circulation and onward to tissues.





    How Well It Works


    These experiments were conducted on animals, so we don’t have human data to draw from. Still, the results were quite encouraging. Subcutaneous hGH was administered to some animals to produce a baseline of comparison. When given by injection, of course, the entire digestive process is bypassed, and bioavailability nears 100 percent. The animals given the oral growth hormone capsules noticed about 11 percent bioavailability in comparison. While not necessarily close, these numbers are remarkable, given the challenge at hand. If they hold true in humans, the raw numbers at least suggest the concept could work. Further, the distribution pattern of the oral hGH might even be considered improved. Though the peak was lower, hormone levels remained elevated for a longer time. In this case, the subcutaneous injection lasted roughly five hours, with most of the hormone lost by hour four. The oral medication produced a slower rising and lowering pattern in serum hGH, but the total distribution lasted for nearly 12 hours.





    What’s Next?


    These experiments are very exciting. But we mustn’t get too far ahead of ourselves. They first need to be replicated in human subjects, of course. The approval to even test this in humans would require several more stages of investigation, and significant financial support (I am not sure if that is there right now). Further, the high cost of somatropin may still preclude the use of this technology in pharmaceuticals. It could still require as much as nine times more hormone for an equivalent (total) delivery to the patient. That is, if the 11 percent bioavailability numbers even hold up. While hGH processing costs have plummeted in recent years, we’re not quite at a place where nine times greater raw materials costs don’t seem daunting. Still, we’re on the right track. For certain, this is a subject I’m going to keep an eye on. I am starting to believe we could see an oral hGH in the not too distant future.





    Reference:


    1. Yanan Shi, Keke Li, et al. Oral delivery of human growth hormone: Preparation, characterization, and pharmacokinetics. J Biomater Appl 2016;Oct 14.
     
    Your Character Is In Your DEEDS. Not Your Dreams!

    Follow Me twitter Iron-Game

  2. #2

    Join Date
    Mar 2015
    Location
    nc mountains
    Posts
    3,210
    Rep Power
    0

    Default

    It would be very cool but I don't mind the sub- q
    Likes Cyber-Suppz liked this post
     

  3. #3
    MuscleChemistry Newbie Board Certified Psy.D

    Join Date
    Sep 2016
    Posts
    76
    Rep Power
    155

    Default

    probably cost 3 times what HGH costs now...i'll stick to subq
    Thanks Cyber-Suppz thanked for this post
    Likes Cyber-Suppz liked this post
     

  4. #4
    MuscleChemistry Member Board Certified Psy.D

    Join Date
    Aug 2013
    Posts
    375
    Rep Power
    0

    Default

    Mk677 is way more efficient and affordable. Seems a pointless waste of study for such a small bioavailability rate


    Sent from my iPhone using Tapatalk
    Likes Cyber-Suppz liked this post
     

  5. #5
    MuscleChemistry Newbie Residency Training

    Join Date
    Feb 2017
    Posts
    9
    Rep Power
    0

    Default

    Where there's a will there's a way

    Sent from my SM-G935P using Tapatalk
     

  6. #6
    MuscleChemistry Registered Member Board Certified MD
    Masher59's Avatar
    Join Date
    May 2014
    Posts
    2,229
    Rep Power
    2147485885

    Default

    So take 10 pills lol.
    Likes Cyber-Suppz liked this post
     

  7. #7
    MuscleChemistry Guru Board Certified MD
    LeatherHead's Avatar
    Join Date
    Aug 2009
    Location
    FLORIDA
    Posts
    6,061
    Rep Power
    2147489723

    Default

    Before the kidney transplant, my son had to take somatropin 6 days a week. By time he was 5, he was administering it to himself in his thighs sub-q. He was on it from 1-12 years old, and once the transplant was done, they took him off of it. Well, there was still a nice little supply in the fridge, and at $500 per vial, I wasn't going to let it go to waste. It was pretty amazing how quickly I grew.
    Likes Cyber-Suppz, Toast_Eater liked this post
     
    Fear No Man In This World... Nor the Next

Similar Threads

  1. GHRP - The Breakthrough HGH Releaser
    By Iron Game in forum Peptide HGH IGF 1 Discussion
    Replies: 1
    Last Post: 06-19-2016, 10:22 AM
  2. GHRP - The Breakthrough HGH Releaser
    By Iron Game in forum Bodybuilding Steroid & Training Articles
    Replies: 0
    Last Post: 06-18-2016, 10:40 PM
  3. Anyone make oral suspensions as opposed to oral solutions?
    By 1ntense in forum Steroid Powder Recipe Discussion
    Replies: 5
    Last Post: 01-02-2016, 11:00 AM
  4. Oral Steroid Doses, Anabolic Cycle Stacks, Beginner and Advanced Female Oral Dosages
    By Presser in forum Bodybuilding Steroid & Training Articles
    Replies: 1
    Last Post: 11-09-2015, 09:05 AM
  5. UFC 88: Breakthrough
    By teedubgee in forum "MMA" Forum
    Replies: 6
    Last Post: 09-08-2008, 10:05 AM

Tags for this Thread

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  

Log in

Log in