Thread: Igf1

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    Currently on a cycle and added igf1 a month ago and I have noticed an increase in the size of my testicles. They where pretty small do to current cycle. Anyone else ever notice this happening to them?
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    Some others have said that here and on other sites I’ve read it , I think we might even have posted a study on this but not positive it’s posted here or if I read it but here it is


    effects of Insulin-like Growth Factor-I on testicular atrophy induced by hypoxia

    Fernando Diez-Caballero, Inma Castilla-Cortázar, [...], and Salvador Gonzalez-Barón
    Additional article information
    Abstract

    Background

    Insulin-like Growth Factor-I (IGF-I) supplementation restores testicular atrophy associated with advanced liver cirrhosis that is a condition of IGF-I deficiency. The aim of this work was to evaluate the effect of IGF-I in rats with ischemia-induced testicular atrophy (AT) without liver disease and consequently with normal serum level of IGF-I.

    Methods

    Testicular atrophy was induced by epinephrine (1, 2 mg/Kg intra-scrotal injection five times per week) during 11 weeks. Then, rats with testicular atrophy (AT) were divided into two groups (n = 10 each): untreated rats (AT) receiving saline sc, and AT+IGF, which were treated with IGF-I (2 μg.100 g b.w.-1.day-1, sc.) for 28d. Healthy controls (CO, n = 10) were studied in parallel. Animals were sacrificed on day 29th. Hypophyso-gonadal axis, IGF-I and IGFBPs levels, testicular morphometry and histopathology, immuno-histochemical studies and antioxidant enzyme activity phospholipid hydroperoxide glutathione peroxidase (PHGPx) were assessed.

    Results

    Compared to controls, AT rats displayed a reduction in testicular size and weight, with histological testicular atrophy, decreased cellular proliferation and transferrin expression, and all of these alterations were slightly improved by IGF-I at low doses. IGF-I therapy increased signifincantly steroidogenesis and PHGPx activity (p < 0.05). Interestingly, plasma IGF-I did not augment in rats with testicular atrophy treated with IGF-I, while IGFBP3 levels, that reduces IGF-I availability, was increased in this group (p < 0.05).

    Conclusion

    In testicular atrophy by hypoxia, condition without IGF-I deficiency, IGF-treatment induces only partial effects. These findings suggest that IGF-I therapy appears as an appropriate treatment in hypogonadism only when this is associated to conditions of IGF-I deficiency (such as Laron Syndrom or liver cirrhosis).



    Background

    Insulin-Like Growth Factor-I (IGF-I) is an anabolic hormone, produced mainly in the liver by GH stimulation [1]. In advanced liver cirrhosis plasma levels of IGF-I are reduced [1] because liver biosynthesis and GH receptor expression in hepatocytes are decreased. Testicular atrophy is a common complication in advanced cirrhosis. Previous results have shown that IGF-I supplementation recovers testicular atrophy associated to experimental cirrhosis [1]. Since advanced cirrhosis is a condition of "IGF-I deficiency" and IGF-I therapy was able to revert testicular atrophy in cirrhotic rats in only three weeks, a direct effect of IGF-I on testes seems to be the most important factor to explain our findings. This idea is supported by the existence of receptors for IGF-I in Sertoli cells, germ cells and Leydig cells [2,3]. Following treatment with exogenous IGF-I patients with Laron dwarfism, a condition of IGF-I deficiency due to the absence of receptors for growth hormone, show an increase in testicular size and serum testosterone levels [4]. Stopping IGF-I administration led to a return of both parameters to the pretreatment situation indicating a specific effect of IGF-I [4].
    On the other hand, since IGF-I therapy was also able to improve nutritional status, intestinal absorption and liver function tests [5-9], other factors could contribute to the gonadal improvement observed in these rats with cirrhosis treated with IGF-I.
    The aims of the present study were: 1) to go more into the beneficial effects of the mechanisms mediated by IGF-I; and 2) investigate if IGF-I therapy could be an adequate treatment to improve testicular function in other conditions without liver disorder and consequently with normal serum levels of IGF-I.
    With these objectives, the present work was carried out using an experimental model of hypoxia-induced testicular atrophy including three groups: healthy controls, untreated rats with testicular atrophy and rats with testicular atrophy treated with low doses of IGF-I during 28 days. Testes histopathology and function, pituitary-gonadal axis and IGF-I and IGFBPs plasma levels were assessed in the three experimental groups.

    Methods

    Induction of testicular atrophy

    Testicular atrophy was induced as previously described [10]. Briefly, male Wistar rats (4 weeks old, 150–160 g) were subjected to 1.2 mg/Kg b.w. five times/week intra-scrotal injections of epinephrine in sterile saline (Sigma), for 11 weeks. Rats were housed in cages placed in a room with 12-hour light-dark cycle and constant humidity and temperature (20°C). Both, food (standard semipurified diet for rodents; B.K. Universal, Sant Vicent del Horts, Spain) and water were given ad libitum. Healthy age-matched control rats were studied in parallel. All experimental procedures were performed in conformity with The Guiding Principles for Research Involving Animals.

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    There’s actually another study out there but I haven’t found it yet , but it shows that igf is effective in reversing raisin nuts
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