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    Default Study shows Muscle Mass Gains with IGF1-1 Lr3 and Resistance Training

    IGF-1 and muscle mass in older adults--PubMed

    Insulin-Like Growth Factor-1 and Resistance Exercise Study shows Gains in Muscle Mass

    Arnarson A1, Gudny Geirsdottir O, Ramel A, Jonsson PV, Thorsdottir



    Abstract

    BACKGROUND:

    Insulin-like growth factor-1 (IGF-1) is related to the preservation of lean body mass. Its decline during ageing is thought to make old adults more susceptible to sarcopenia and functional dependency. The aim of the present study was to investigate circulating total IGF-1 in old adults who engaged in a 12-weeks of progressive resistance training.
    DESIGN:

    Intervention study.
    SETTING:

    Community.
    PARTICIPANTS:

    Old Icelandic adults (N = 235, 73.7 ± 5.7 years, 58.2% female).
    INTERVENTION:

    Twelve-week resistance exercise program (3 times/week; 3 sets, 6-8 repetitions at 75-80% of the 1-repetition maximum) designed to increase strength and muscle mass of major muscle groups.
    MEASUREMENTS:

    IGF-1.
    RESULTS:

    At baseline IGF-1 was significantly associated with lean body mass and appendicular muscle mass (also when corrected for age, gender and various covariates). After the training IGF-1 decreased significantly from 112.1 ± 35.6 to 106.1 ± 35.2 µg/L during the course of the study. On and individual level, IGF-1 decreased in 59% and increased in 39% of the participants. Changes in IGF-1 were inversely related to changes in lean body mass (rho = -0.176, P = 0.013 ) and appendicular muscle mass (rho = -0.162, P = 0.019) also when corrected for protein intake, age, gender, and other covariates.
    CONCLUSION:

    Serum total IGF-1 decreases after 12 weeks of resistance exercise in community dwelling old adults. When looked at IGF-1 changes for participants individually it becomes clear that IGF-1 response to resistances exercise is highly variable. Changes in IGF-1 are negatively related to changes in lean body mass during training, which supports the hypothesis that IGF-1 is redistributed from circulation into tissue during periods of active muscle building
     

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    Good study
    Study shows Muscle Mass Gains with IGF1-1 Lr3 and Resistance Training

  3. #3
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    good one.
    Get It Done!

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    Good read
    Likes drtbear1967 liked this post
     
    Study shows Muscle Mass Gains with IGF1-1 Lr3 and Resistance Training

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