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    Default FOLLISTATIN and BODYBUILDING

    FOLLISTATIN and BODYBUILDING


    With new products entering the market all the time, nothing has hit like the recent storm about Follistatin. But the problem is; no one knows anything about this compound and its true power! So I’m here to break some things down for you.
    Follistatin, simply put, it a protein that is a myostatin antagonist (or myostatin-binding protein). Myostatin, as we know, regulates our body’s muscle growth, kind of like a governor in cars. Myostatin is produced by our bodies naturally to limit our skeletal muscle growth, so that our muscles grow “in proportion” to our body. Thus, we have circulating in our blood stream, a gene that will literally inhibit our growth naturally. Not something we want right? Also, myostatin levels have been seen to be dramatically higher in later weeks of anabolic cycles. This is believed to be the reason as to why most gains are usually seen in the first 10 weeks of a cycle, because after that, myostatin levels peak and really limit your muscle growth. But what if that could be changed? If we could block myostatin, we could potentially see these 12 to 15 weeks cycles making constant gains, which would be something that is rarely to never seen. “In men treated with graded doses of testosterone, myostatin levels were significantly higher on day 56 than baseline in both young and older men; changes in myostatin levels were significantly correlated with changes in total and free testosterone in young men.”This is where follistatin comes in. Follistatin is used to inhibit myostatin activity in vitro resulting in skeletal muscle growth in vivo. Simply, when follistatin is introduced, a shortage in myostatin is seen which results muscle growth. Studies have backed up this, and research on monkeys and other mammals began after rodent trials were shown successful. The result of follistatin treatment was a significant increase in muscle mass and strength. In one study I paid particular attention to, Follistatin over expression increased the muscle weight by about 37% in control animals! Another study looked at, showed not only an increase in skeletal muscle, but a decrease in fat accumulation! What we also found interesting is that our bodies already produce an increased amount of follistatin with exercise! I see this as another one of the ways our body is kind of “turned=on” to muscle growth in retaliation of exercise. After many trials, it was conclusive that follistatin seems to be quite successful in inhibiting myostatin, which results in these muscle and strength gains.
    So what we have here is, a protein that binds with another which limits our muscle growth, that is naturally released with exercise, which induces an increase in muscle mass and a decrease in fat storage. A way for us to take our longer cycles to full potential, and see gains past week 10, while off cycle still pushing our bodies to produce gains that have normally been inhibited. This amazing compound is new to the market, and at a price as it is quite an expensive compound to produce. But with its potential to be a staple in long cycles, and off-cycle growth, it may just be gold. Dosing for follistatin is pretty high, usually around 100mcg a day as a 1mg bottle will only be good in the fridge for about a week before some serious degradation happens, and at the price we are paying for it, it is best to make sure we use it fast and at its full potential. Recent logs have shown gains of a little more then 1 pound per day in small 7 to 10 day cycles.
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    I am hoping to have an opportunity to try this in the future. I'll see if I can find the link about about it, but I'm going to do the whole bottle at once. Hopefully 1mg a week for 2 or 3 weeks or what ever I can afford.

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    Sounds nasty!! Lovin the sound of it Brother
     

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    This definitely has me interested....what would the difference be in, for example, to take it 100mcg daily or just to take the whole bottle at once? Just preference or by taking it all at once you avoid the risk of it going to waste before used or what?
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    Very good info and tempting too -Follastatin , I know it'snew but wat r the sides associated with it? Thanks
     

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    Quote Originally Posted by THASHIZ View Post
    This definitely has me interested....what would the difference be in, for example, to take it 100mcg daily or just to take the whole bottle at once? Just preference or by taking it all at once you avoid the risk of it going to waste before used or what?
    Good question. Simple answer is both. Of the logs I've seen that were successful, all started with a blast dose of 1mg. I think of it like Nolvadex or an Anti E. It takes X amount to bind up all the receptors or X amount to bind up all the aromatase. Short of that and you really don't get too much in the way of effects.
    In addition there exists the opinion that Folli degrades quickly in solution. Folli also has a decent half life in the body. For me it just makes sense to blast it in. I'm really planning this out. A friend of Silk's is turning 30 next weekend and wants us to go to the strip club with her and her boyfriend. If it looks like a possibility I'm going to hold off on this. I want to be 100% on board with this as I feel that's the only way to get an honest eval.
    I think this stuff might be a big thing in bodybuilding, but right now.not alot of people have $450 to drop on 3 bottles....
    I'll tell you what.... Should I gain 3lbs off 3mg of Folli, my next run will be with 5mg of Folli.
    I know you guys are interested, but I'm chomping at the bit

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    Last edited by The Dude; 10-26-2014 at 08:32 AM.
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    I would love to give Folli a try, but my wife, who handles the household finances, would shit at the expense it would take to run a decent cycle of Folli.
     

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    Quote Originally Posted by BEASTZ6 View Post
    I would love to give Folli a try, but my wife, who handles the household finances, would shit at the expense it would take to run a decent cycle of Folli.
    It's expensive, but from what I've seen it is comparable to using a decent dose of GH, but produces more effects and much faster...

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    Figure a good price for generic GH is $1.25 per iu... so $265 a month and most don't see shit for 6 months. With a bulk deal you could probably get 3mg of Folli for close to that and feel and see results after the first dose... It's expensive, but it works and you are going to get legit stuff where as GH even from well known suppliers is still a big risk... so close to 3mg of legit Folli or 210 iu of maybe decent GH (maybe fake or severely under dosed). This is just my perspective
    Last edited by The Dude; 11-11-2014 at 10:23 PM.
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    I wouldnt mind running some Ace-031 or any Anti-Myostatin that I knew for certain was real, just way too many fakes out there now days to trust just buying from any old Peptide or research chemical store

    But yeah i wouldnt mind giving this a solid run
    FOLLISTATIN and BODYBUILDING

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    not sure how true it is, and i just found our own article on google search so lol, so thought i would mention, or ask how true it is, that now i read that you would need to attach the follistatin to somehting so it wasnt killed right away by anti-bodies, or i know i read that in studies they gave the subjects somehting that would first lower their entire bodies immune system before administering the follistatin, or whatever anti myostatin drug it was,

    anyhow, from all i have read, all of the more popular ones foll, ace 031 etc all would be useless and destroyed right away, anyone know more?
    FOLLISTATIN and BODYBUILDING

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    Quote Originally Posted by Presser View Post
    not sure how true it is, and i just found our own article on google search so lol, so thought i would mention, or ask how true it is, that now i read that you would need to attach the follistatin to somehting so it wasnt killed right away by anti-bodies, or i know i read that in studies they gave the subjects somehting that would first lower their entire bodies immune system before administering the follistatin, or whatever anti myostatin drug it was,

    anyhow, from all i have read, all of the more popular ones foll, ace 031 etc all would be useless and destroyed right away, anyone know more?
    Nothing...but I will bump.
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    Quote Originally Posted by Presser View Post
    I wouldnt mind running some Ace-031 or any Anti-Myostatin that I knew for certain was real, just way too many fakes out there now days to trust just buying from any old Peptide or research chemical store

    But yeah i wouldnt mind giving this a solid run
    I was going to mention that. From what I have heard it is hard to find the real deal. I think it is too expensive of a gamble. Although, people could be spreading that rumour because it rocks and they want to keep the edge. Who knows...
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    For it to work you need to attach it to or delive r it within adeno-associated virus/AAV , or take immune suppressing drugs, and I accidently deleted last post here where he said Follistatin is like any other peptide and if antibodies would eat up follistatin they would also eat up igf-1 lr3, and thats actually not the case, they arent even closely related (follistatin and IGF-1lr3) follistatin works to bind to another form of growth factor called Tranforming Growth Factor or Tgf , which regulates growth, and it works by Inhibiting this growth factor.

    Everything i have read suggests you can NOT just inject follistatin and think it will work, every study ive read says they need to gut out a virus of everything but the shell (cell walls) and deliver the follistatin this way for it to work effectiviely.

    Lastly all those dramatic photos you guys see of the cows with giant muscles on top of muscles and giant might mice lol, those are all geneticaly engineered to not have the myostatin gene that limits muscle growth, those are NOT from injecting a myostatin inhibitor like folli or ace et ..




    Im up for some science though on the issue? if anyone has a study they want to share that shows you can just inject follistatin and it works, please share it.


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    Quote Originally Posted by Dean Destructo View Post
    I was going to mention that. From what I have heard it is hard to find the real deal. I think it is too expensive of a gamble. Although, people could be spreading that rumour because it rocks and they want to keep the edge. Who knows...

    Ya know, as retarded as that might sound at first, i wouldnt doubt it brutha! I do know other real bio/cell cutlture type companies like Cell Sciences will put out information on how their products arent for human use, which we expect, but will also go the extra distance and say shit like certain products they carry can cause great bodily harm etc.. and this on shit that we already know works well, so i wouldnt doubt it, However with this particular subject on Myostatin Inhibitors , i have read actual studies stating they needed to be attached to viruses, or we would need to take an Imune System suppression drug first, which i say NO THANKS!
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    myostatin inhibitors used by bodybuilders information. Just a bump tot he top on follistatin
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    This follistatin and ace 031 I think it was called, anyhow point is, none of these Myostatin Inhibitors really took off did they? Or am I living under a rock out in east bumble fuck-all? lmao


    Anything new out there in the works by big Pharma on myostatin blocking / inhibiting ???
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    Quote Originally Posted by Presser View Post
    For it to work you need to attach it to or delive r it within adeno-associated virus/AAV , or take immune suppressing drugs, and I accidently deleted last post here where he said Follistatin is like any other peptide and if antibodies would eat up follistatin they would also eat up igf-1 lr3, and thats actually not the case, they arent even closely related (follistatin and IGF-1lr3) follistatin works to bind to another form of growth factor called Tranforming Growth Factor or Tgf , which regulates growth, and it works by Inhibiting this growth factor.

    Everything i have read suggests you can NOT just inject follistatin and think it will work, every study ive read says they need to gut out a virus of everything but the shell (cell walls) and deliver the follistatin this way for it to work effectiviely.

    Lastly all those dramatic photos you guys see of the cows with giant muscles on top of muscles and giant might mice lol, those are all geneticaly engineered to not have the myostatin gene that limits muscle growth, those are NOT from injecting a myostatin inhibitor like folli or ace et ..




    Im up for some science though on the issue? if anyone has a study they want to share that shows you can just inject follistatin and it works, please share it.


    Anyone ever had any notible gains running any type of myostatin inhibitor?
    FOLLISTATIN and BODYBUILDING

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    myostatin inhibitor read
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