drtbear1967

Musclechemistry Board Certified Member
What is CARDARINE?
CARDARINE is the PUREST form of GW-501516 on the market today. Sarms is THE ONLY place that offers this brand. Many other companies attempt to market a product they claim is GW-501516 and while it may possess partial GW-501516, it is not the pure form. Sarms provides everyone with the pure form of GW-501516 and the most potent formula on the market today. As soon as you open your sealed bottle of CARDARINE, the difference from any other brand is apparent. The thickness and quality of CARDARINE is far different than any other form of GW-501516 that you will find. REAL and PURE GW is a much thicker molecule than actual SARMS are. GW often gets grouped with SARMS however it is technically a PPAR Modulator. This is quite different and should be apparent in appearance and texture. Being that it is a thicker molecule, the texture should be significantly different yet so many other companies offer GW that is just as liquified as other SARMS are. This can show a user immediately that they are not getting the pure form they should be getting. If this is not enough, many companies purposely underdose their research products. At sarms, each batch and bottle is carefully formulated and measured with precision and approximation to ensure that all research done with each bottle will be accurate and allow for precise results.
The qualities and results that come along with CARDARINE use are simply described in one word, "AMAZING." There are several extreme benefits that come along with CARDAROINE use but the two most apparent and popular are that of EXTREME ENDURANCE INCREASES as well as EXTREME FAT MELTING WHILE STILL PRESERVING MUSCLES.
The amount of endurance that can be built with GW use is astounding… A user will start to build their vo2 max within days of initial use and can continue to build it throughout the entire cycle. Once the vo2 max is built, a user can continue to hold on to their increase as long as they continue to train as they were. The beauty of all of this is that not only will GW increase your endurance with cardio, it will also maximize your lifting capabilities. The recovery time in between sets is unreal and the output will increase every workout. This is very significant because it allows a lifter to put forth maximal effort each workout. A lifter can lift more at a much more efficient rate and truly get the most out of every time they are in the gym or doing cardio.
GW will MELT fat at a rapid pace, yet it is non catabolic. This makes GW ideal for EVERYONE. Many people are scared of dropping weight because of the possibility of muscle loss. GW allows for fat loss while preserving muscle. This is all diet dependent but this makes GW extremely desirable for anyone and everyone.
Another huge benefit that is associated with GW is the effect it has on cholesterol. GW has shown to increase good cholesterol and lower bad cholesterol. Clearly, this is extremely important and appealing to everyone
 
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Hello, since i need to loose fat, i am taking hgh 4ui split
and t4, i would like to know of this cardarine is really effective
and if it is the case to add it
thanks
 
Looks worth trying. I'd be willing to be a test mule and report back. I'll see about buying some and then I'll start a log.
 
I think that if no one had never reported usage and results is not good to have a so high risk, i read that can cause cancer, so i think is better to avoid its use.
SO it is better everybody keep away from it
 
I think that if no one had never reported usage and results is not good to have a so high risk, i read that can cause cancer, so i think is better to avoid its use.
SO it is better everybody keep away from it

Hello @James115 The study that suggested GW-501516 (GW or Cardarine) caused cancer has been determined by most to be very flawed. It was done on mice using MANY, MANY times the maximum recommended research dose. In fact if you take that many times the recommended dose of aspirin or tylenol you wouldn't have to wait for cancer you would be dead. It was also not done in a controlled manner, meaning there were too many other factors to make that conclusion. In fact that study has been discredited time and time again. I will post some studies below but have to dig them up.
I will always agree with the fact you should error on the side of caution. I just want you to be fully informed.
 
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Looks worth trying. I'd be willing to be a test mule and report back. I'll see about buying some and then I'll start a log.

@LeatherHead TheSupplementOutlet.com is going to start carrying GW-501516 (GW or Cardarine) any day. It took me a while to find a good, quality product but we got it. As a respected member here it would be great if you would log it. I will PM you.
 
PPARb/d ligands do not potentiate growth of human cancer cell lines---PUBMED ARTICLE

[h=1]Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines.[/h]Hollingshead HE1, Killins RL, Borland MG, Girroir EE, Billin AN, Willson TM, Sharma AK, Amin S, Gonzalez FJ, Peters JM.
[h=3]Author information[/h]

[h=3]Abstract[/h]<abstracttext>Ligands for peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) increase skeletal muscle fatty acid catabolism, improve insulin sensitivity, increase serum high-density lipoprotein cholesterol, elicit anti-inflammatory activity and induce terminal differentiation. Contradictory findings are also reported suggesting that PPARbeta/delta ligands potentiate tumorigenesis by increasing cell proliferation, by inhibiting apoptosis through phosphorylation of Akt and by increasing cyclooxygenase-2 (COX2) and vascular endothelial growth factor (VEGF) expression. The contradictory findings could be due to differences in the model system (cancer cell line versus in vivo), differences in cell culture conditions (with and without serum) or differences in ligands. The present study examined the effect of two different PPARbeta/delta ligands (GW0742 and GW501516) in human cancer cell lines (HT29, HCT116, LS-174T, HepG2 and HuH7) cultured in the presence or absence of serum and compared in vitro analysis with in vivo analysis. Neither PPARbeta/delta ligand increased cell growth or phosphorylation of Akt and no increase in the expression of VEGF or COX2 were detected in any cancer cell line in the presence or absence of serum. Similarly, liver, colon and colon polyps from mice administered these PPARbeta/delta ligands in vivo did not exhibit changes in these markers. Results from these studies demonstrate that serum withdrawal and/or differences in ligands do not underlie the disparity in responses reported in the literature. The quantitative nature of the present findings are inconsistent with the hypothesis that cancer cell lines respond differentially as compared with normal cells, and provide further evidence that PPARbeta/delta ligands do not potentiate tumorigenesis.</abstracttext>


<dl class="rprtid" style="margin-right: 15px; margin-left: 0px; font-size: 0.8465em; line-height: 1.4em; display: inline;"><dt style="display: inline; padding: 0px; margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px !important; white-space: nowrap;">PMID:</dt> <dd style="margin: 0px; display: inline; padding: 0px; white-space: nowrap;">17693664</dd> <dt style="display: inline; padding: 0px; margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 10px !important; white-space: nowrap;">DOI:</dt> <dd style="margin: 0px; display: inline; padding: 0px; white-space: nowrap;">10.1093/carcin/bgm183</dd></dl>


The full article can be found at-https://www.ncbi.nlm.nih.gov/pubmed/17693664
 
[h=1]Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines.[/h]Hollingshead HE1, Killins RL, Borland MG, Girroir EE, Billin AN, Willson TM, Sharma AK, Amin S, Gonzalez FJ, Peters JM.
[h=3]Author information[/h]

[h=3]Abstract[/h]<abstracttext>Ligands for peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) increase skeletal muscle fatty acid catabolism, improve insulin sensitivity, increase serum high-density lipoprotein cholesterol, elicit anti-inflammatory activity and induce terminal differentiation. Contradictory findings are also reported suggesting that PPARbeta/delta ligands potentiate tumorigenesis by increasing cell proliferation, by inhibiting apoptosis through phosphorylation of Akt and by increasing cyclooxygenase-2 (COX2) and vascular endothelial growth factor (VEGF) expression. The contradictory findings could be due to differences in the model system (cancer cell line versus in vivo), differences in cell culture conditions (with and without serum) or differences in ligands. The present study examined the effect of two different PPARbeta/delta ligands (GW0742 and GW501516) in human cancer cell lines (HT29, HCT116, LS-174T, HepG2 and HuH7) cultured in the presence or absence of serum and compared in vitro analysis with in vivo analysis. Neither PPARbeta/delta ligand increased cell growth or phosphorylation of Akt and no increase in the expression of VEGF or COX2 were detected in any cancer cell line in the presence or absence of serum. Similarly, liver, colon and colon polyps from mice administered these PPARbeta/delta ligands in vivo did not exhibit changes in these markers. Results from these studies demonstrate that serum withdrawal and/or differences in ligands do not underlie the disparity in responses reported in the literature. The quantitative nature of the present findings are inconsistent with the hypothesis that cancer cell lines respond differentially as compared with normal cells, and provide further evidence that PPARbeta/delta ligands do not potentiate tumorigenesis.</abstracttext>


<dl class="rprtid" style="margin-right: 15px; margin-left: 0px; font-size: 0.8465em; line-height: 1.4em; display: inline;"><dt style="display: inline; padding: 0px; margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px !important; white-space: nowrap;">PMID:</dt> <dd style="margin: 0px; display: inline; padding: 0px; white-space: nowrap;">17693664</dd> <dt style="display: inline; padding: 0px; margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 10px !important; white-space: nowrap;">DOI:</dt> <dd style="margin: 0px; display: inline; padding: 0px; white-space: nowrap;">10.1093/carcin/bgm183</dd></dl>


The full article can be found at-https://www.ncbi.nlm.nih.gov/pubmed/17693664
Good additional information
 
I think there is a big need for the best SARM info to come out on melting fat. We have things out there that are either extremely dangerous (DNP) or will make 85% or more cramp like crazy (such as clen) other things can mess with your thyroid and once that's out of whack good fucking luck. We def have a need for a lot of info on fat burning safer products in this market! :D
 
I think there is a big need for the best SARM info to come out on melting fat. We have things out there that are either extremely dangerous (DNP) or will make 85% or more cramp like crazy (such as clen) other things can mess with your thyroid and once that's out of whack good fucking luck. We def have a need for a lot of info on fat burning safer products in this market! :D
I have used clen and it's nothing. I have also used speed in my past coke, amphetamines, ecstacy. With my history clen is nothing. I was using it way too high and everyone corrected me so I looked it up. I went down from 240 to 160. Lol!
I have put so much into my body but besides that would like to say that Tren is supposed to stimulate central nervous system and in me it does. I don't recommend tren with clen blood pressure issue can cause problems.
I am on 40 mg adderall a day and tren gives me hell

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I have a gram or so of gw and some caps left over from Hardcore back in the day. I also have some T-var and Dienolone Base. The T-var is good have used alot among alot of their powders. Everything I got from them was good. The gw caps where from them too

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I think there is a big need for the best SARM info to come out on melting fat. We have things out there that are either extremely dangerous (DNP) or will make 85% or more cramp like crazy (such as clen) other things can mess with your thyroid and once that's out of whack good fucking luck. We def have a need for a lot of info on fat burning safer products in this market! :D


Perhaps this will be my next article. Thank you
 
Hello @James115 The study that suggested GW-501516 (GW or Cardarine) caused cancer has been determined by most to be very flawed. It was done on mice using MANY, MANY times the maximum recommended research dose. In fact if you take that many times the recommended dose of aspirin or tylenol you wouldn't have to wait for cancer you would be dead. It was also not done in a controlled manner, meaning there were too many other factors to make that conclusion. In fact that study has been discredited time and time again. I will post some studies below but have to dig them up.
I will always agree with the fact you should error on the side of caution. I just want you to be fully informed.
That is right, the study that suggest that was rats. Rats taking the human equivalent to prolly 1000 mg a day.
Plus it was inconclusive some rats at that does didn't get cell change. Some with cancer got better. Some got worse.


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Hello @James115 The study that suggested GW-501516 (GW or Cardarine) caused cancer has been determined by most to be very flawed. It was done on mice using MANY, MANY times the maximum recommended research dose. In fact if you take that many times the recommended dose of aspirin or tylenol you wouldn't have to wait for cancer you would be dead. It was also not done in a controlled manner, meaning there were too many other factors to make that conclusion. In fact that study has been discredited time and time again. I will post some studies below but have to dig them up.
I will always agree with the fact you should error on the side of caution. I just want you to be fully informed.
There was a simular study about aspartame years ago. People overweight still bring it up to avoid diet products!!! Lol

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I've been posting about it in another thread... But this cardarine is awesome. No more night sweats, no insomnia, mood swings are down, and fat is going away without adding in cardio or changing my diet. I'm still eating like I'm bulking, but the fat is going away. After this bottle, I'm going to to buy another bottle and see how awesome it is when I eat better and add in cardio.
 
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