1. #1
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    Default What is CARDARINE??

    What is CARDARINE?
    CARDARINE is the PUREST form of GW-501516 on the market today. Sarms is THE ONLY place that offers this brand. Many other companies attempt to market a product they claim is GW-501516 and while it may possess partial GW-501516, it is not the pure form. Sarms provides everyone with the pure form of GW-501516 and the most potent formula on the market today. As soon as you open your sealed bottle of CARDARINE, the difference from any other brand is apparent. The thickness and quality of CARDARINE is far different than any other form of GW-501516 that you will find. REAL and PURE GW is a much thicker molecule than actual SARMS are. GW often gets grouped with SARMS however it is technically a PPAR Modulator. This is quite different and should be apparent in appearance and texture. Being that it is a thicker molecule, the texture should be significantly different yet so many other companies offer GW that is just as liquified as other SARMS are. This can show a user immediately that they are not getting the pure form they should be getting. If this is not enough, many companies purposely underdose their research products. At sarms, each batch and bottle is carefully formulated and measured with precision and approximation to ensure that all research done with each bottle will be accurate and allow for precise results.
    The qualities and results that come along with CARDARINE use are simply described in one word, "AMAZING." There are several extreme benefits that come along with CARDAROINE use but the two most apparent and popular are that of EXTREME ENDURANCE INCREASES as well as EXTREME FAT MELTING WHILE STILL PRESERVING MUSCLES.
    The amount of endurance that can be built with GW use is astounding… A user will start to build their vo2 max within days of initial use and can continue to build it throughout the entire cycle. Once the vo2 max is built, a user can continue to hold on to their increase as long as they continue to train as they were. The beauty of all of this is that not only will GW increase your endurance with cardio, it will also maximize your lifting capabilities. The recovery time in between sets is unreal and the output will increase every workout. This is very significant because it allows a lifter to put forth maximal effort each workout. A lifter can lift more at a much more efficient rate and truly get the most out of every time they are in the gym or doing cardio.
    GW will MELT fat at a rapid pace, yet it is non catabolic. This makes GW ideal for EVERYONE. Many people are scared of dropping weight because of the possibility of muscle loss. GW allows for fat loss while preserving muscle. This is all diet dependent but this makes GW extremely desirable for anyone and everyone.
    Another huge benefit that is associated with GW is the effect it has on cholesterol. GW has shown to increase good cholesterol and lower bad cholesterol. Clearly, this is extremely important and appealing to everyone
    Last edited by Iron Game; 12-13-2016 at 11:10 AM. Reason: Ads, links
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    Hello, since i need to loose fat, i am taking hgh 4ui split
    and t4, i would like to know of this cardarine is really effective
    and if it is the case to add it
    thanks
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    It would be worth a try, especially with the stack you are running.
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    Quote Originally Posted by drtbear1967 View Post
    It would be worth a try, especially with the stack you are running.
    yes,but is there anybody that has tried it and obtained good results?
    thanks
     

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    Looks worth trying. I'd be willing to be a test mule and report back. I'll see about buying some and then I'll start a log.
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    I think that if no one had never reported usage and results is not good to have a so high risk, i read that can cause cancer, so i think is better to avoid its use.
    SO it is better everybody keep away from it
     

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    Quote Originally Posted by James115 View Post
    I think that if no one had never reported usage and results is not good to have a so high risk, i read that can cause cancer, so i think is better to avoid its use.
    SO it is better everybody keep away from it
    Hello @James115 The study that suggested GW-501516 (GW or Cardarine) caused cancer has been determined by most to be very flawed. It was done on mice using MANY, MANY times the maximum recommended research dose. In fact if you take that many times the recommended dose of aspirin or tylenol you wouldn't have to wait for cancer you would be dead. It was also not done in a controlled manner, meaning there were too many other factors to make that conclusion. In fact that study has been discredited time and time again. I will post some studies below but have to dig them up.
    I will always agree with the fact you should error on the side of caution. I just want you to be fully informed.
    Last edited by Iron Game; 01-14-2017 at 01:07 AM.
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    Quote Originally Posted by LeatherHead View Post
    Looks worth trying. I'd be willing to be a test mule and report back. I'll see about buying some and then I'll start a log.
    @LeatherHead TheSupplementOutlet.com is going to start carrying GW-501516 (GW or Cardarine) any day. It took me a while to find a good, quality product but we got it. As a respected member here it would be great if you would log it. I will PM you.
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    Default PPARb/d ligands do not potentiate growth of human cancer cell lines---PUBMED ARTICLE

    Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines.

    Hollingshead HE1, Killins RL, Borland MG, Girroir EE, Billin AN, Willson TM, Sharma AK, Amin S, Gonzalez FJ, Peters JM.
    Author information


    Abstract

    Ligands for peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) increase skeletal muscle fatty acid catabolism, improve insulin sensitivity, increase serum high-density lipoprotein cholesterol, elicit anti-inflammatory activity and induce terminal differentiation. Contradictory findings are also reported suggesting that PPARbeta/delta ligands potentiate tumorigenesis by increasing cell proliferation, by inhibiting apoptosis through phosphorylation of Akt and by increasing cyclooxygenase-2 (COX2) and vascular endothelial growth factor (VEGF) expression. The contradictory findings could be due to differences in the model system (cancer cell line versus in vivo), differences in cell culture conditions (with and without serum) or differences in ligands. The present study examined the effect of two different PPARbeta/delta ligands (GW0742 and GW501516) in human cancer cell lines (HT29, HCT116, LS-174T, HepG2 and HuH7) cultured in the presence or absence of serum and compared in vitro analysis with in vivo analysis. Neither PPARbeta/delta ligand increased cell growth or phosphorylation of Akt and no increase in the expression of VEGF or COX2 were detected in any cancer cell line in the presence or absence of serum. Similarly, liver, colon and colon polyps from mice administered these PPARbeta/delta ligands in vivo did not exhibit changes in these markers. Results from these studies demonstrate that serum withdrawal and/or differences in ligands do not underlie the disparity in responses reported in the literature. The quantitative nature of the present findings are inconsistent with the hypothesis that cancer cell lines respond differentially as compared with normal cells, and provide further evidence that PPARbeta/delta ligands do not potentiate tumorigenesis.


    PMID:
    17693664
    DOI:
    10.1093/carcin/bgm183



    The full article can be found at-https://www.ncbi.nlm.nih.gov/pubmed/17693664
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    Quote Originally Posted by T.S.O. View Post
    Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines.

    Hollingshead HE1, Killins RL, Borland MG, Girroir EE, Billin AN, Willson TM, Sharma AK, Amin S, Gonzalez FJ, Peters JM.
    Author information


    Abstract

    Ligands for peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) increase skeletal muscle fatty acid catabolism, improve insulin sensitivity, increase serum high-density lipoprotein cholesterol, elicit anti-inflammatory activity and induce terminal differentiation. Contradictory findings are also reported suggesting that PPARbeta/delta ligands potentiate tumorigenesis by increasing cell proliferation, by inhibiting apoptosis through phosphorylation of Akt and by increasing cyclooxygenase-2 (COX2) and vascular endothelial growth factor (VEGF) expression. The contradictory findings could be due to differences in the model system (cancer cell line versus in vivo), differences in cell culture conditions (with and without serum) or differences in ligands. The present study examined the effect of two different PPARbeta/delta ligands (GW0742 and GW501516) in human cancer cell lines (HT29, HCT116, LS-174T, HepG2 and HuH7) cultured in the presence or absence of serum and compared in vitro analysis with in vivo analysis. Neither PPARbeta/delta ligand increased cell growth or phosphorylation of Akt and no increase in the expression of VEGF or COX2 were detected in any cancer cell line in the presence or absence of serum. Similarly, liver, colon and colon polyps from mice administered these PPARbeta/delta ligands in vivo did not exhibit changes in these markers. Results from these studies demonstrate that serum withdrawal and/or differences in ligands do not underlie the disparity in responses reported in the literature. The quantitative nature of the present findings are inconsistent with the hypothesis that cancer cell lines respond differentially as compared with normal cells, and provide further evidence that PPARbeta/delta ligands do not potentiate tumorigenesis.


    PMID:
    17693664
    DOI:
    10.1093/carcin/bgm183



    The full article can be found at-https://www.ncbi.nlm.nih.gov/pubmed/17693664
    Good additional information
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    I think there is a big need for the best SARM info to come out on melting fat. We have things out there that are either extremely dangerous (DNP) or will make 85% or more cramp like crazy (such as clen) other things can mess with your thyroid and once that's out of whack good fucking luck. We def have a need for a lot of info on fat burning safer products in this market!
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    Quote Originally Posted by Metal85 View Post
    I think there is a big need for the best SARM info to come out on melting fat. We have things out there that are either extremely dangerous (DNP) or will make 85% or more cramp like crazy (such as clen) other things can mess with your thyroid and once that's out of whack good fucking luck. We def have a need for a lot of info on fat burning safer products in this market!
    I have used clen and it's nothing. I have also used speed in my past coke, amphetamines, ecstacy. With my history clen is nothing. I was using it way too high and everyone corrected me so I looked it up. I went down from 240 to 160. Lol!
    I have put so much into my body but besides that would like to say that Tren is supposed to stimulate central nervous system and in me it does. I don't recommend tren with clen blood pressure issue can cause problems.
    I am on 40 mg adderall a day and tren gives me hell

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    I have a gram or so of gw and some caps left over from Hardcore back in the day. I also have some T-var and Dienolone Base. The T-var is good have used alot among alot of their powders. Everything I got from them was good. The gw caps where from them too

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    Quote Originally Posted by Metal85 View Post
    I think there is a big need for the best SARM info to come out on melting fat. We have things out there that are either extremely dangerous (DNP) or will make 85% or more cramp like crazy (such as clen) other things can mess with your thyroid and once that's out of whack good fucking luck. We def have a need for a lot of info on fat burning safer products in this market!

    Perhaps this will be my next article. Thank you
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    As promised CARDARINE is now available here - - CARDARINE
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    Quote Originally Posted by T.S.O. View Post
    Hello @James115 The study that suggested GW-501516 (GW or Cardarine) caused cancer has been determined by most to be very flawed. It was done on mice using MANY, MANY times the maximum recommended research dose. In fact if you take that many times the recommended dose of aspirin or tylenol you wouldn't have to wait for cancer you would be dead. It was also not done in a controlled manner, meaning there were too many other factors to make that conclusion. In fact that study has been discredited time and time again. I will post some studies below but have to dig them up.
    I will always agree with the fact you should error on the side of caution. I just want you to be fully informed.
    That is right, the study that suggest that was rats. Rats taking the human equivalent to prolly 1000 mg a day.
    Plus it was inconclusive some rats at that does didn't get cell change. Some with cancer got better. Some got worse.


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    Quote Originally Posted by T.S.O. View Post
    Hello @James115 The study that suggested GW-501516 (GW or Cardarine) caused cancer has been determined by most to be very flawed. It was done on mice using MANY, MANY times the maximum recommended research dose. In fact if you take that many times the recommended dose of aspirin or tylenol you wouldn't have to wait for cancer you would be dead. It was also not done in a controlled manner, meaning there were too many other factors to make that conclusion. In fact that study has been discredited time and time again. I will post some studies below but have to dig them up.
    I will always agree with the fact you should error on the side of caution. I just want you to be fully informed.
    There was a simular study about aspartame years ago. People overweight still bring it up to avoid diet products!!! Lol

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    bump
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    bump.. waiting on some feedback from members.
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    I've been posting about it in another thread... But this cardarine is awesome. No more night sweats, no insomnia, mood swings are down, and fat is going away without adding in cardio or changing my diet. I'm still eating like I'm bulking, but the fat is going away. After this bottle, I'm going to to buy another bottle and see how awesome it is when I eat better and add in cardio.
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    Awesome, I cannot wait to see how you do.
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    CARDARINE & Best Suited SARMs Stacks





    SARM Guide:
    • About
    • Reaction
    • Scholarly Articles, and Uses In medicine
    • Who Uses SARM
    • Negative and Posotive Sides
    • Dosage and Duration
    • Stacking & Synergies
    • Recommended products





    About Cardarine

    Cardarine (GW-501516, GW1516, GSK-516 or endurobol) is a substance that acts as a modulator of hormone receptors. GW-501516 AMP activates protein kinase, the activation stimulates glucose uptake in skeletal muscles. The formulation has been proposed as a potential treatment of obesity and related with it conditions, particularly when used in combination with a synergistic compound AICAR.



    Reaction

    Cardarine is a selective PPARδ receptor activator. It displays a high affinity (K i = 1 Nm) and capacity (EC 50 = 1 Nm) of the PPARδ with a > 1000 times selectivity over PPARa and PPARy.


    In mammals, the aplication of GW-501516, involves the activator PGC-1a by acting on PPARδ. The PPARδ coactivator increases the expression of proteins involved in energy costs. In addition, in rats treated with cardarine recognised an increased metabolism of fatty acid in skeletal muscles and protection against diet leading to obesity and type II diabetes! In obese rhesus monkeys, GW-501516 increased the level of high density lipoprotein (HDL) and lowered the level of lipoproteins of very low density (VLDL). Mechanisms of action of PPARδ agonists slightly increase HDL. It seems to be due to increased expression of ABCA1 – the transporter of cholesterol.


    Scholarly Articles, and Uses In medicine

    When administered cardarine, it was shown that it reverses metabolic disorders in obese people with a pre-diabetes metabolic syndrome, probably by stimulating the oxidation of fatty acids. Cardarine was proposed as a potential preparation for the treatment of obesity and related with it conditions. With AICAR you can greatly improve the efficiency of GW-501516.



    Who uses SARM Enduro GW (Cardarine)

    There are two main uses Endurobol GW-501516 in sport.


    • The first and most common in use is the effect of increased endurance. Cardarine was banned for professional athletes, because of the unfair advantage in terms of endurance. The formulation causes a strong increase of endurance. Users of cardarine will find that it is a key preparation in this aspect. A typical dose showing effects on muscle endurance increase is only 10 mg per day.
    • The second advantage of using GW-501516 is the loss of body fat. Many users applying the measure confirms the increased loss of fat tissue, as well as the anti-catabolic effect. Thanks to cardarine you'll find that you can burn fat without losing muscles. This phenomenon occurs especially when you use it in combination with Ostarine and S4 to keep as much muscle as possible. A dose of 10 mg per day shows efficacy in a loss of fat, but an increase to 20 mg per day will allow you to achieve much better results.



    Effects Positive & Negative

    Cardarine is not a hormone, so it does not block the HPTA. Despite its oral form, it does not contain a harmful methyl group.



    How Much & How LONG


    Dosage and Duration of enduro gw
    A recommended dose for cardarine is 10-20 mg, and the cyclicality of application is 8 weeks. Thanks to the half-life of approximately 20-24 hours, you can use the preparation once a day. In the case of larger doses you can take two portions every 8-10 hours.



    Stacking and Synergistic Effects When Combined


    • Recomposition: Cardarine (Enduro GW) + S4 Andarine + IGF-1 Lr3 (20 mg + 60 mg + 50mcg)
    • Increase lean muscle mass and fat loss: Cardarine + IGF-1 lr3 + Andarine (20 mg + 60 mcg + 75 mg)
    • Increase in endurance: Cardarine + Stenabolic SR9009



    Recommended products


    • RND Solution
    • SARM Sciences
    • Liquid Labs IGF-1 lr3




    What is CARDARINE??

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