1. #1
    Musclechemistry Board Certified Member Board Certified MD
    drtbear1967's Avatar
    Join Date
    Aug 2016
    Location
    Kentucky
    Posts
    5,663
    Rep Power
    2147489318

    Default Cardarine - Profile

    Cardarine (GW-501516) is drug that binds to the PPAR receptor. It was first created by Glaxo Smith Kline and Ligand Pharmaceuticals in 1992. It was discovered that Cardarine, when binding to the PPAR receptor, recruits what is called the coactivator PGC-1α enzyme, which then increases the expression of genes involved in the expenditure of energy. Rats treated with Cardarine were shown to have increased fatty acid metabolism and increased protection against obesity from eating a bad diet, as well as an increased protection from type-2 diabetes. In another study on Rhesus monkeys, cardarine was shown to increase HDL (good cholesterol) and decrease LDL (bad cholesterol). Reasons for this effect appeared to be caused by an increased expression of the cholesterol transporter ABCA1. In other words, cardarine activates the same genetic pathways that are involved in exercise. In addition, cardarine was studied for use in treating cardio disease before its development was halted in 2007.

    What is Cardarine Used for?

    Cardarine is great for pretty much everything! Incredible endurance benefits from it are probably the most prominent reason to use this product. Not only has it proven to increase endurance in scientific studies, but when you use it for yourself you'd see that the results are nothing short of amazing! If you're a cardio junkie or just like getting lean, it increase your run times. Your weight lifting sessions will be extended further, you'll feel energized longer and ultimately get a lot more work done before you walk out of the gym every day.Of course, fat loss is at the top of the list of reasons why many people love Cardarine so much. Striations and veins get more noticeable and your journey to fat loss becomes a lot easier, without the catabolic effects that most fat burners and drugs can have while trimming down. Fat loss from cardarine is a result of increased glucose uptake in skeletal muscle. Essentially, you're making better use of the nutrients you consume every day and decreasing the amount of carbohydrates or fat stored as adipose tissue. As a result, cardarine is not only fat burning and anti-catabolic, but it's also a little bit anabolic as well.Cardarine can be stacked with pretty much anything, and it will enhance the results of the cycle. For anabolic-androgenic steroid users who like the drug trenbolone, cardarine is fantastic at combating the negative side effects of “tren” and even enhancing the positive effects.

    Dosages

    Cardarine will give benefits in both endurance and fat oxidation at 10-15mgs per day for an ideal 8 week cycle; however, 20mg per day for 8-12 weeks is the recommended dose to get you the absolute optimum results in and out of the gym. Cardarine is a banned substance in certain sports, so it's recommended you are careful with its use if you're a tested athlete.


    Everyone always asks, where's the proof that Cardarine help my health? Let's review the studies guy.
    Study #1: https://www.ncbi.nlm.nih.gov/pubmed/24767130
    Done by: International Journal of Cardiology
    CONCLUSION: Our data indicate that PPARβ/δ activation might be useful to prevent the harmful effects of ER stress induced by saturated fatty acids in the heart by inducing autophagy.
    Explanation: In simple terms, this study shows Cardarine was shown to be useful in preventing heart attacks.

    Study #2: https://www.ncbi.nlm.nih.gov/pubmed/25063273
    Done by: Diabetologia Journal of Medicine
    CONCLUSIONS: Overall, these findings indicate that PPARβ/δ prevents ER stress, inflammation and insulin resistance in skeletal muscle cells by activating AMPK.





    Side Effects

    Cardarine is virtually side effect free. Although some studies have appeared to show a small increase in some cancer rate in mice (not humans), they were done for a very long time with outrageous doses no where near recommended human doses. In some cases giving up to 1000 times (thousand!) the recommended dose. Obviously, if you take 1000 pills of anything, it's dangerous. Imagine, if you took 1000 pills of Aspirin! You'd be dead after the first 50. So, always take things in perspective. Ultimately there is not enough evidence of this to be conclusive. However, other studies have shown no significant connection to cancer at all, and further studies even showed cardarine to decrease tumor size. Meaning, it helped cure some cancers.Conclusion

    Cardarine is an all around amazing performance enhancer that will give anyone an edge in the gym and “in the kitchen,” no matter what their short or long term goals are. Whether you need it as cycle support to combat side effects of trenbolone, or you want to fully utilize cardarine's potential to help you reach your goals in building lean muscle and fat loss, it stands above the rest as one of the most helpful fitness and health tools to date.
    Thanks Presser thanked for this post
    Likes Presser liked this post
     
    Get It Done!

  2. #2
    Presser's Avatar
    Join Date
    May 2002
    Posts
    41,686
    Rep Power
    2147525355

    Default

    Very good read and worth a bump and social share
    Thanks drtbear1967 thanked for this post
    Likes Maj7900 liked this post
     
    Cardarine - Profile

  3. #3
    MuscleChemistry Guru Board Certified DMD
    Maj7900's Avatar
    Join Date
    Feb 2018
    Posts
    659
    Rep Power
    2147484313

    Default

    Cardio in a bottle is a great name for it. Good breakdown and I especially like how you even mentioned it’s connection to cancer cells with mice. I’ve read and heard about this a few times but the rate is low in mice so the effect are proven. I like to get it and use it as a pre when I’m off cycle


    Team MeccaGear!
     

Similar Threads

  1. Fat loss power of GW501516 aka Cardarine profile Endurobol.
    By guardianactual in forum MuscleChemistry Discussion
    Replies: 118
    Last Post: 02-04-2024, 09:36 AM
  2. What is CARDARINE??
    By drtbear1967 in forum Peptide HGH IGF 1 Discussion
    Replies: 21
    Last Post: 08-05-2018, 01:19 PM
  3. Cardarine
    By blacktail in forum MuscleChemistry Discussion
    Replies: 2
    Last Post: 09-29-2017, 01:09 PM
  4. GW-50 (Cardarine) Profile
    By drtbear1967 in forum Peptide HGH IGF 1 Discussion
    Replies: 9
    Last Post: 05-25-2017, 12:31 PM
  5. cardarine
    By warlord in forum MuscleChemistry Discussion
    Replies: 3
    Last Post: 03-14-2016, 08:59 PM

Tags for this Thread

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  

Log in

Log in