1. #1
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    Default YK-11 is a myostatin inhibitor that actually works.

    YK11 stimulates the creation of follistatin. When YK11 is in the presence of follistatin, it causes a large sudden production of myogenic differentiation factor (MyoD), myogenic factor 5 (Myf5) and myogenin. The three myogenic items are what causes the body to create new muscle cells. Testosterone and DHT compounds also do this, but without the creation or need for follistatin. Well, not quite correct, testosterone does induce the creation of follistatin, just not nearly at the same level as YK11. Normally, the body produces myostatin as a counter to mygenin (it competes for the same receptors and then encourages the body to destroy the newly created muscle cells), to help keep the body from just making more and more muscle (which is normally what we want). Follistatin aids in the reducing the effect of myostatin in a few ways, but that is outside the scope of what I am talking about. It is this follistatin that makes YK11 so powerful compared to testosterone or DHT compounds (and why testosterone is still a better choice for muscle creation than other AAS - it is a perfect item to use in synergy with other items).


    The human body, being an insanely amazing thing, is not powerless against follistatin. As follistatin levels rise, it creates an anti-follistatin antibody. This anti-body helps restore the body back to its normal state so there is not run-away muscle creation (again, that would be a bad thing).


    YK11 is only partially androgenic and it has the same effects on FKBP51 as DHT compounds do, in other words, it increases it quite a bit. This is only a problem if you currently have cancer, as FKBP51 is instrumental in cell survival and it will also greatly aid cancer cells in their survival. If you have cancer, do not take YK11...and also do not take any compound that turns into DHT in the body. Yeah, that is just about every good AAS out there. Remember, cancer is no joke, so if you have it, getting rid of it should be your number one priority...not gaining muscle. Don't be a loser about it and die just to look good at your funeral. For the vast majority of people without cancer, there is no problem with having an increased FKBP51 level. Increased FKBP51 levels does NOT cause cancer.


    I have found no side effects at all for YK11 (other than the increase in FKBP51, which you also find in most AAS), but it is still a very new SARM so only time will tell. There is also no suggested dosing by the medical community, again due to it being so new. As far as I can tell, it has yet to be used on a live creature by the medical community - it has only been used on cell cultures. At least they were human cell cultures. Welcome to the bleeding edge here folks! Myostatin encourages muscle atrophy, follistatin encourages muscle creation (more or less correct for both) and they both compete for the same receptors. EDIT: Side effects have started to be reported - a weakening of the tendons.


    YK11 also does not appear to cause the creation of Estrogen - it appears to do the same thing as Tamoxifen (though through a completely different method) but to a far lesser degree. YK11 cannot be used as a SERM replacement so please do not try.


    What we need to keep an eye out for is nosebleeds. ACE31 was a myostatin inhibitor with great promise, made it into phase 2 human trials where they tested it on both people with muscular dystrophy and healthy people. It caused bad nosebleeds that stopped when the drug was no longer taken. It has been shelved until someone can figure out how to stop the bleeding. Since YK11 also appears to inhibit myostatin (though through completely different mechanisms), there is always the chance it will cause nosebleeds as well. They have no idea why ACE31 causes nosebleeds, but it did it with enough power and frequency to kill what looked like a huge money maker for the big pharma developing it. I doubt YK11 will cause nosebleeds, due to the way it works, but it is better to keep an eye out for it and it never happen than it to happen and you think it is caused by the change in seasons.




    For me, YK11 looks like something I would like to try out. I think it, combined with a good AAS regimen, could help push me to greater heights
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    good read, and all the reading ive done suggests that most myostatin inhibitors out there are useless due to our bodies creating anti-bodies to the inhibitor, and i also read some studies stating it had to be package in a custom virus to help prevent it from being eaten up and even then they had to administer something to help reduce the immunue system(fuck that) lol.

    So all these guys saying how great follistatin or ace-031 is, i think are placebo effects, or trying to promote the myo inhibitor for sale.

    Basically the studies stated you cant just take an anti myostatin and it work, it had to be packed in another virus and the subject also needed their immune system supressed,
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    I really like this article. The original writer must be amazing! I wonder who that might be?
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    Quote Originally Posted by cybrsage View Post
    I really like this article. The original writer must be amazing! I wonder who that might be?
    I think it was basskiller. Not sure where really, lol.
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    It was me, but no problem. I thought I had already posted it here but obviously had not. Thanks for posting the info, people need it.
    Last edited by cybrsage; 02-11-2016 at 06:11 PM.
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    Quote Originally Posted by cybrsage View Post
    It was me, but no problem. I thought I had already posted it here but obviously had not. Thanks for posting the info, people need it.
    Damn brutha, good article. Thanks for not caring I repost it. I'm excited about giving this stuff a try.
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    I am too, after a long run of low level HGH to help build tendon strength. Since tendon weakness appears to be the only side effect (so far), I am being proactive about it. I already have a bottle waiting for me to use.
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    Quote Originally Posted by cybrsage View Post
    I am too, after a long run of low level HGH to help build tendon strength. Since tendon weakness appears to be the only side effect (so far), I am being proactive about it. I already have a bottle waiting for me to use.
    Great idea!
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    Thanks to sharing the informations Iron-game ;-)

    Anyone have test the Yk-11 ?
    I give maybe a try for one month, some people report nice pump and great gains with it.

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    Quote Originally Posted by cybrsage View Post
    I really like this article. The original writer must be amazing! I wonder who that might be?
    Do you have anything else that is Original and that you would like to share here with MuscleChemistry.com ? Or do you have any up coming articles ? We would be happy have them, maybe even work out a pay per article deal.

    I have a bunch of high traffic keyword articles i would like here that would be of great interest to our readers here. Even some old articles here teetering on top 3 positions of googles 1st page that couls use a rewrite up, or addon to origanl threads article.

    Anyhow, thanks for sharing your myostatin inhibiter aka yk11 article, or at least for letting us steal it from you lmao

    "er" was on purpose BTW
    Last edited by Presser; 09-02-2017 at 02:07 PM.
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    We could use some new myostatin inhibitor articles here at MuscleChemistry.com if anyone wants to share
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    YK-11 is a myostatin inhibitor that actually works.

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    Where can I Buy Myostatin? Do Myostatin products work?

    These are pretty popular questions on many forums, i did search muscle chemistry for this topic to see how many had it wrong, but the topic was covered well, or the members here at least knew that if you are trying to build muscle, Myostatin is not your friend. hahaha

    So i thought i would share some useful basic knowledge on the MSTN gene that Limits and Controlls growth of the muscle, not build muscle. The only way this gene will produce muscle hypertrophy is through a mutation of this gene.

    Other names for this Gene are as follow:


    • GDF-8
    • GDF8
    • GDF8_HUMAN
    • growth differentiation factor 8



    The MSTN gene provides instructions for making a protein called myostatin. This protein is part of the transforming growth factor beta (TGFβ) superfamily, which is a group of proteins that help control the growth and development of tissues throughout the body. Myostatin is found almost exclusively in muscles used for movement (skeletal muscles), where it is active both before and after birth. This protein normally restrains muscle growth, ensuring that muscles do not grow too large. Myostatin has been studied extensively in mice, cows, and other animals, and it appears to have a similar function in humans.

    Researchers are studying myostatin as a potential treatment for various muscular dystrophies that cause muscle weakness and wasting (atrophy).



    Cybersage that was a well written article in initial post. Thank you
     

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    I achieved fairly decent results with it. Still got a few unopened bottles here! Won't kick into them though until next cycle.

    - - - Updated - - -

    And I guess you could argue anybody including them in a cycle would confound the results a little bit lol!
    Area-1255;"the last of the honest bloggers".
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