MK 677 and prolactin

Ok heres my experience with effectiveness heres all my labs.
My current regimen is 75 mg test cyp mon fri. Anastrozole 0.50 mg on injection days. Mk 677 12.5 mg daily pm dosage. As you can see the mk worked igf levels rose quite a bit but negitavely prolactin doubled had to go get caber to help that at 25 mg the igf results would be great but not at the expense of my dick being jello. Dont know if caber at that doseage would be enough to counter prolactin problems which is, 0.50 mg 2 times per week
Any input guys thanks just sharing.

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My prolactin values befor and after mk 677

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HULK1972 said:

Ok heres my experience with effectiveness heres all my labs.
My current regimen is 75 mg test cyp mon fri. Anastrozole 0.50 mg on injection days. Mk 677 12.5 mg daily pm dosage. As you can see the mk worked igf levels rose quite a bit but negitavely prolactin doubled had to go get caber to help that at 25 mg the igf results would be great but not at the expense of my dick being jello. Dont know if caber at that doseage would be enough to counter prolactin problems which is, 0.50 mg 2 times per week
Any input guys thanks just sharing.

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Prolactin values before and after mk.

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HULK1972 said:

Ok heres my experience with effectiveness heres all my labs.
My current regimen is 75 mg test cyp mon fri. Anastrozole 0.50 mg on injection days. Mk 677 12.5 mg daily pm dosage. As you can see the mk worked igf levels rose quite a bit but negitavely prolactin doubled had to go get caber to help that at 25 mg the igf results would be great but not at the expense of my dick being jello. Dont know if caber at that doseage would be enough to counter prolactin problems which is, 0.50 mg 2 times per week
Any input guys thanks just sharing.

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Yikes

I would be concerned with the purity of your MK-677.

MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism.Randomized controlled trial

Murphy MG, et al. J Clin Endocrinol Metab. 1998.

Show full citation

Abstract

The reversal of diet-induced negative nitrogen balance by GH suggests a possible therapeutic role for GH treatment in catabolic patients. A double-blind, randomized, placebo-controlled, two-period cross-over study was designed to investigate whether MK-677, an orally active nonpeptide mimic of GH-releasing peptide, can reverse diet-induced protein catabolism. Eight healthy volunteers (ages 24-39 yr) were calorically restricted (18 kcal/kg.day) for two 14-day periods. During the last 7 days of each diet period, subjects received either oral MK-677 25 mg or placebo once daily. There was a 14- to 21-day washout interval between periods. During the first week of caloric restriction (i.e. diet alone), daily nitrogen losses were similar for both treatment groups (mean +/- SE; MK-677 group -2.67 +/- 0.40 g/day vs. placebo group -2.83 +/- 0.26 g/day). During the second week (diet and study drug), mean daily nitrogen balance was 0.31 +/- 0.21 g/day in the MK-677 treatment group compared with -1.48 +/- 0.21 g/day in the placebo group (P < 0.01). MK-677 improved nitrogen balance integrated over the 7 days of treatment; area under the curve day 8-14 nitrogen balance response was +2.69 +/- 5.0 (SE) for MK-677 and -8.97 +/- 5.26 g.day for placebo (P < 0.001). MK-677 produced a peak GH response of 55.9 +/- 31.7 micrograms/L after single dose (day 1 of treatment) and 22.6 +/- 9.3 micrograms/L after a week of dosing compared with placebo treatment peak GH values of approximately 9 (treatment day 1) and approximately 7 micrograms/L (treatment day 7). Following the initial 7-day caloric restriction, insulin-like growth factor-I (IGF-I) declined from 232 +/- 25 to 186 +/- 19 ng/mL in the MK-677 group and from 236 +/- 19 to 174 +/- 23 ng/mL in the placebo group. Mean IGF-I concentration increased significantly during MK-677 to 264 +/- 31 ng/mL (mean for the last 5 days of treatment) compared with 188 +/- 19 ng/mL with placebo (P < 0.01). No significant difference in IGF binding protein-2 was found between the MK-677 and placebo treatments. However, the mean in IGF binding protein-3 for the last 5 days of MK-677 treatment was also significantly increased to 3273 +/- 330 ng/mL (mean +/- SE) compared with placebo 2604 +/- 253 ng/mL (P < 0.01). Neither the serum cortisol nor the PRL response was significantly greater after 7 days of MK-677 dosing compared with 7 days of placebo. MK-677 (25 mg) was generally well tolerated and without clinically significant adverse experiences. In conclusion, MK-677 reverses diet-induced nitrogen wasting, suggesting that if these short-term anabolic effects are maintained in patients who are catabolic because of certain acute or chronic disease states, it may be useful in treating catabolic conditions.

PMID*9467534 [PubMed - indexed for MEDLINE]

Iron-game said:

I would be concerned with the purity of your MK-677.

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Ya I considered that as well, and It could be my system getting used to what mk does. All in all id have some caber on hand in case you respond like I did. I can tell you the caber did the trick as far as sides go it helped after the first dose.

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Keep us updated brother.

Hey guys with the caber im on is it possible to "crash" prolactin and get sides that way? Im on 0.5 mon fri. Any help is appreciated.

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