1. #1
    Musclechemistry Board Certified Member Board Certified MD
    drtbear1967's Avatar
    Join Date
    Aug 2016
    Location
    Kentucky
    Posts
    5,663
    Rep Power
    2147489318

    Default SR9009 - More Research

    theguerillachemist

    Bodybuilders know the compound SR9009, improperly called a SARM, for its potential to help burn fat. I’ve written my opinion about this in several posts, but this 2018 paper in Nature(the prestigious journal) caught my attention.

    SR9009 is an REV-ERB agonist that affects certain nuclear hormone receptors that are essential to your body’s natural circadian rhythm. These researchers have shown IN VIVO(mice) that SR9009 has a lethal effect on cancer cells, but has no effect on normal healthy cells. This study shows SR9009 affects certain drivers for oncogenic activity such as HRAS, PIK3CA and BRAF, and triggers apoptosis, which is programmed cell death(in malignant tumor cells only). This study showed that SR9009 inhibited glioblastoma(brain cancer) growth in mice “without causing overt toxicity.” This is very exciting, although further research is needed. There are other papers that have shown REV-ERB agonists to be toxic to breast cancer in vitro(cells), as well as quite a few papers on a link between disruption of the circadian clock in mammals and cancer.

    This is early stage research but hopefully the affecting the circadian rhythm can be an effective anti-cancer treatment. The main downfall for SR9009 is its low oral bioavailability, some papers cite as low as 2.9%. A topical or injectable version might be a more viable option.
    Thanks Presser thanked for this post
    Likes guardianactual liked this post
     
    Get It Done!

  2. #2
    MuscleChemistry Registered Member Board Certified MD
    guardianactual's Avatar
    Join Date
    Mar 2014
    Posts
    2,150
    Rep Power
    2147485808

    Default

    Interesting stuff. I wanted to buy this stuff and give it a go, but between the brands to choose from and the fact they are all oral, I wasn't feeling it.

    Maybe someone well known and respected as a company will make a topical or injectable version soon.
    Thanks drtbear1967 thanked for this post
    Likes Presser liked this post
     
    WICKR name:
    User12701978

    You must believe in yourself enough now, to become the person, others will remember you for later

    Our greatest fear is not that we are inadequate, Our greatest fear is that we are powerful beyond measure.

  3. #3
    Musclechemistry Board Certified Member Board Certified MD
    drtbear1967's Avatar
    Join Date
    Aug 2016
    Location
    Kentucky
    Posts
    5,663
    Rep Power
    2147489318

    Default

    With all the positive aspects of this compound, you would think an injectable is forthcoming.
    Likes Presser liked this post
     
    Get It Done!

  4. #4
    Presser's Avatar
    Join Date
    May 2002
    Posts
    41,688
    Rep Power
    2147525357

    Default

    I havent tried it yet for the record, but plan to, and only for one reason whch is what guardianactual posted. I would like to know if you can still feel the effects orally. And i thought it was a popular injection years agao no? For some reason i thought it was.
    SR9009 - More Research

Similar Threads

  1. Where to buy sr9009?
    By reallywt in forum Peptide HGH IGF 1 Discussion
    Replies: 11
    Last Post: 08-09-2018, 03:44 PM
  2. Stenabolic Sr9009
    By Presser in forum Bodybuilding Steroid & Training Articles
    Replies: 1
    Last Post: 07-20-2018, 01:37 PM
  3. SARM Stenabolic - SR9009
    By drtbear1967 in forum Peptide HGH IGF 1 Discussion
    Replies: 5
    Last Post: 06-25-2018, 05:15 PM
  4. SR9009 Andarine powder stocked
    By Bulkraws in forum MuscleChemistry Discussion
    Replies: 0
    Last Post: 10-29-2017, 11:33 PM

Tags for this Thread

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  

Log in

Log in