drtbear1967
Musclechemistry Board Certified Member
theguerillachemist
In light of getting so many questions about the difference between 1,3 vs 1,4-DMAA, I figured a post is needed to clarify the differences. Both molecules are naturally occurring and were detected in geranium extract in the nanogram level(10^-9g), and that's pretty much where the published data ends for 1,4-DMAA. Structurally, the only difference between the 2 compounds is the position of a methyl group(carbon 3 vs carbon 4). This change is a significant enough to change the euphoric effects and allows for a more lipophilic binding interaction, similar to adderall. 1,4 acts as a catecholamine releasing agent, increasing levels of dopamine and norepinephrine. As far as potency goes, the "sweet spot" for 1,4 seems to be 100-150mg vs 50-75mg of 1,3. However, the feeling you get from 1,4 is a cleaner, more euphoric, uplifting feeling compared to the "gritty" stim feeling from 1,3. This might be Bc of the structural change which may make it a stronger releasing agent and thus having higher dopamine and serotonin levels. I, personally love 1,4 as a stim and I was never a huge 1,3 but the positive affect it has on mood elevation and focus are unrivaled in an OTC supplement. At 150mg, you sweat a lot even when it's cold inside and some of my coworkers have likened it to a "mini roll." I'm not sure what products have it right now, as DMAA has been banned, but it is still being battled in court. I would stick up on anything you can get if you like DMAA as it might be gone forever. Worth noting- 1,4 is the correct structure to the ambiguously named "2-amino isoheptane" but most companies use a completely different molecule, DMHA. 1,4 is NOT DMHA! I guess most people aren't familiar with how to count carbons correctly.
In light of getting so many questions about the difference between 1,3 vs 1,4-DMAA, I figured a post is needed to clarify the differences. Both molecules are naturally occurring and were detected in geranium extract in the nanogram level(10^-9g), and that's pretty much where the published data ends for 1,4-DMAA. Structurally, the only difference between the 2 compounds is the position of a methyl group(carbon 3 vs carbon 4). This change is a significant enough to change the euphoric effects and allows for a more lipophilic binding interaction, similar to adderall. 1,4 acts as a catecholamine releasing agent, increasing levels of dopamine and norepinephrine. As far as potency goes, the "sweet spot" for 1,4 seems to be 100-150mg vs 50-75mg of 1,3. However, the feeling you get from 1,4 is a cleaner, more euphoric, uplifting feeling compared to the "gritty" stim feeling from 1,3. This might be Bc of the structural change which may make it a stronger releasing agent and thus having higher dopamine and serotonin levels. I, personally love 1,4 as a stim and I was never a huge 1,3 but the positive affect it has on mood elevation and focus are unrivaled in an OTC supplement. At 150mg, you sweat a lot even when it's cold inside and some of my coworkers have likened it to a "mini roll." I'm not sure what products have it right now, as DMAA has been banned, but it is still being battled in court. I would stick up on anything you can get if you like DMAA as it might be gone forever. Worth noting- 1,4 is the correct structure to the ambiguously named "2-amino isoheptane" but most companies use a completely different molecule, DMHA. 1,4 is NOT DMHA! I guess most people aren't familiar with how to count carbons correctly.
