1. #1
    Musclechemistry Board Certified Member Board Certified MD
    drtbear1967's Avatar
    Join Date
    Aug 2016
    Location
    Kentucky
    Posts
    5,663
    Rep Power
    2147489318

    Default Methylliberine - New Nootropic

    One of the newest nootropic supplements on the market is methylliberine, most commonly seen as the branded Dynamine. Methylliberine is known as a methylurate, which differs structurally from methylxanthines(caffeine, theobromine) by having an oxo group on the 5 membered ring, and is more similar to theacrine(TeaCrine). The “methyl” part of methylliberine is the methoxy group in the bottom left of the molecule, which makes the molecule more lipid soluble and can more easily cross the blood-brain barrier. It’s naturally found in green coffee beans, teas, and kola nuts, just like caffeine(mostly Coffee robusta).

    While there is not much on published studies yet, I speak to the owners of Dynamine quite often and they have some pharmacokinetic data showing it acts much more quickly than TeaCrine(which peaks in 2hr). They also say the mechanism of action is similar to caffeine by allosterically blocking the adenosine receptor, but claim it’s strictly neuro-active and doesn’t affect heart rate or blood pressure. Onset is about 15 min and peaks at about 60min. There are quite a few studies in the works, including combinations of Dynamine, TeaCrine and caffeine, as it’s been shown that TeaCrine can increase caffeine plasma levels. The suggested dosing is 100-200mg, with a lower dose needed if stacked with TeaCrine and caffeine.

    I will say that I do like the combo of all 3, as I recently tried it at the Arnold last week. I do think there is merit to methylliberine on its own, and I’m very interested to see what the new studies show when they are published. Worth noting, in a powdered form, methylliberine is a 40% material like TeaCrine, but in capsules it is 100% pure. It’s extremely bitter!! I also suggest stacking with a choline source like alpha GPC, CDP-choline or DMAE.
    Likes yellow snow liked this post
     
    Get It Done!

  2. #2
    Presser's Avatar
    Join Date
    May 2002
    Posts
    41,686
    Rep Power
    2147525355

    Default

    WHAT IS DYNAMINE METHYLLIBERINE?

    Dynamine™ is methylliberine, a purine alkaloid found in the kucha tea leaf. Its molecular structure is similar to theacrine (aka TeaCrine) and is believed to behave in similar ways in the body. Like theacrine, methylliberine may amplify feelings of energy, mood and focus by activating dopamine receptors and other key neurotransmitters, and inhibiting adenosine receptors.
    DYNAMINE METHYLLIBERINE QUICK FACTS

    1. From the developers & innovators of TeaCrine comes Dynamine, the newest in fast-acting, high-impact energy, mood, motivation and focus (E-M-M-F).
    2. Dynamine is a purine alkaloid fround in the kucha tea leaf.
    3. Early observations show Dynamine, while structurally very similar to TeaCrine, improves feelings of energy, mood, motivation and focus (E-M-M-F) with much faster onset of action.
    4. Dynamine is safe for athletes. Have confidence adding DynamineTM into your regimen. It is now Informed-Choice, Informed-Sport certified.

    COMPARING DYNAMINE METHYLLIBERINE AND THEACRINE


    So what are the differences of Dynamine Methylliberine vs. Theacrine? Compared to Theacrine, Dynamine Methylliberine is faster acting and higher impacting on energy, mood, motivation and focus. People taking Dynamine Methylliberine for energy report feeling the effects sooner than they would with Theacrine. Another one of Dynamine Methylliberine benefits is that it appears to behave as a negative allosteric modulator of adenosine receptors. Caffeine acts as a direct antagonist on the adenosine receptors, which is mostly responsible for creating feelings of alertness and wakefulness. Since Dynamine Methylliberine acts as an allosteric modulator, it reduces the sensitivity of adenosine receptors which should lead to reduced tolerance build up, compared to caffeine, a direct antagonist. Anecdotal reports show that Dynamine Methylliberine benefits may include activation of dopamine receptors and other neurotransmitters without an impact on the cardiovascular system.

    DYNAMINE METHYLLIBERINE BENEFITS

    • Promotes Fast-Acting Energy
    • Support Mood
    • Heighten Focus

    DYNAMINE METHYLLIBERINE DOSAGE

    As a dietary supplement, take 100mg of Dynamine Methylliberine 1-2 times daily.
    Likes drtbear1967 liked this post
     
    Methylliberine - New Nootropic

  3. #3
    Musclechemistry Board Certified Member Board Certified MD
    drtbear1967's Avatar
    Join Date
    Aug 2016
    Location
    Kentucky
    Posts
    5,663
    Rep Power
    2147489318

    Default

    Good Stuff
    Get It Done!

Similar Threads

  1. L-Tyrosine - Nootropic to start the day.
    By drtbear1967 in forum Supplements Discussion
    Replies: 0
    Last Post: 09-18-2018, 08:18 AM
  2. IDRA-21 is a NOOTROPIC that Improves Attention and Overall Cognition.
    By Presser in forum General Conversation Forum
    Replies: 1
    Last Post: 04-25-2018, 01:53 PM
  3. Nootropic Alpha-GPC
    By drtbear1967 in forum Diet & Nutrition Forum
    Replies: 0
    Last Post: 03-28-2018, 08:09 AM
  4. Coluracetam For Anxiety and as a Nootropic
    By Iron Game in forum Peptide HGH IGF 1 Discussion
    Replies: 2
    Last Post: 08-11-2017, 12:24 AM
  5. Nootropic: Noopept studies and experience
    By guardianactual in forum Bodybuilding Steroid & Training Articles
    Replies: 0
    Last Post: 02-22-2015, 03:41 PM

Tags for this Thread

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  

Log in

Log in