drtbear1967
Musclechemistry Board Certified Member
For general health purposes, few supplements appear more effective than berberine. Berberine has been shown several times over to reduce cholesterol and improve insulin sensitivity in both rodent and human studies. However, when considering bodybuilding application, berberine has been shown to impair protein synthesis, meaning that bodybuilders might want to stick to the lower end of the dosage spectrum and avoid taking berberine around their workouts.
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Based on:
Wang, Y., & Zidichouski, J. A. (2018). Update on the benefits and mechanisms of action of the bioactive vegetal alkaloid berberine on lipid metabolism and homeostasis. Cholesterol, 2018.
Wang, H., Liu, D., Cao, P., Lecker, S., & Hu, Z. (2010). Atrogin-1 affects muscle protein synthesis and degradation when energy metabolism is impaired by the antidiabetes drug berberine. Diabetes, 59(8), 1879-1889
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Based on: Wang, Y., & Zidichouski, J. A. (2018). Update on the benefits and mechanisms of action of the bioactive vegetal alkaloid berberine on lipid metabolism and homeostasis. Cholesterol, 2018. Wang, H., Liu, D., Cao, P., Lecker, S., & Hu, Z. (2010). Atrogin-1 affects muscle protein synthesis and degradation when energy metabolism is impaired by the antidiabetes drug berberine. Diabetes, 59(8), 1879-1889
