mechanism

Insulin-like Growth Factor 1 (IGF-1) is a hormone that plays a crucial role in childhood growth and continues to have anabolic effects in adults. The anabolic mechanism of IGF-1, especially in the context of muscle growth and repair, involves several key processes: 1. **Muscle Protein...

HOW DOES MUSCLE GROW, EXACTLY? ⁣ I mean, we know that eventually, if we train with weights we end up gaining some muscle mass.. but how ? Short answer: we don't know yet, exactly. And that's because we don't have a 100% clear answer. However, we have many pieces of the puzzle that can help us...

Metabolic Stress & Hypertrophy: do metabolites create muscle growth ? In the current model of hypertrophy, and the mechanisms behind it, 3 are the "main" ways through which hypertrophy occurs: ⁣ ⁣ 1) Mechanical Tension⁣ 2) Metabolic Stress⁣ 3) Muscle Damage (which we've already seen it actually...

Yohimbine is an alpha-2 adrenergic antagonist that can release fatty acids(increase lipolysis)from cells via increased noradrenaline levels. It seems to be in almost every “fat burner” on the market, but does it really help with fat loss?? Surprisingly there are not a lot human studies but the...

Only a handful of studies have shown potential evidence of hyperplasia in humans – this is partly due to the fact that the most popular mechanism to induce hyperplasia is very difficult to study in humans. This mechanism involves using very heavy loads in stretched positions for long amounts of...

theguerillachemist This preliminary study was just released showing the effects of 8 healthy trained males ingesting a ketone monoester(KE) or a placebo along with a protein/glucose mixture post workout. The KE is the monoester beta-hydroxybutyrate, 1,3-butandiol. The protocol was listed as...

Letrozole and nolvadex cannot be used together! Nolvadex lowers the effectiveness of letrozole by 38% through an unknown mechanism. However, I know several competitors who have told me they take both concurrently Bc their "coaches" don't have a clue about drug interactions. Be smart and do your...

There has always been a lot of anecdotal evidence by gym rats saying that the anabolic steroid nandrolone decanoate(Deca) can help alleviate joint point, but is there any science to back this claim up? It turns out that there may in fact be a mechanism that could explain this phenomena. This...

For all my brotha's getting ready to put together those winter bulking regimens,thought this might come in handy for you... Anabolic Steroids achieve their effects on hypertrophy through different mechanisms,and as such are classified into two different categories,class-I and class-II...