1. #1
    Musclechemistry Member Board Certified CPH
    akn's Avatar
    Join Date
    Aug 2013
    here n there
    Rep Power

    Default Testopel® Pellets ( testosterone replacement therapy) TRT profile

    Testopel® is a testosterone delivery system comprised of

    small cylindrical pellets of pressed testosterone. The pellets
    are sterile, and are comprised almost purely of testosterone,

    barring a small amount of added binders for stability. These

    pellets are implanted subcutaneously, and provide the patient
    a continuous and very even release of hormone for several
    months. Testosterone pellets have the advantage of allowing
    the patient to not think about their hormone replacement
    therapy on a daily, weekly, or monthly basis as with many
    other hormone delivery systems, and provide a much more
    even release of hormone (less highs and lows) than popular
    injections. Testosterone implant pellets, however, have the
    disadvantage of requiring that the patient undergo minor
    office surgery twice to several times per year.
    Soon after the oral delivery of testosterone was deemed
    impractical due to rapid first pass metabolism, it was
    realized that pressed pellets of surgically implanted sterile
    testosterone could provide physiological androgen levels for
    extended periods of time to patients in need of such therapy.
    Implanted testosterone pellets were accepted very early as
    viable options for delivering testosterone, and various such
    commercial preparations have been introduced and
    prescribed over the years (although historically injectable
    esters and suspensions of testosterone have been the norm in
    this field of medicine).
    Currently, Bartor Pharmacal produces the only commercially
    available brand of testosterone pellet in the U.S., sold as
    Testopel. Each pellet contains 75 mg of (free) testosterone. It
    is FDA-approved for use in adult males with conditions
    associated with a deficiency or absence of endogenous
    testosterone. This includes cases of primary hypogonadism
    caused by cryptorchidism, bilateral torsion, orchitis,
    vanishing testis syndrome, orchiectomy, Kline
    syndrome, chemotherapy, or alcohol/heavy metal toxicity. It
    is also prescribed to treat hypogonadotrophic hypogonadism
    caused by tumors, injury, or radiation. FDA laws also allow
    certain private compounding pharmacies to manufacture
    generic testosterone implant pellet preparations.
    Testosterone implant pellets are not commonly made outside
    the U.S., but can be located in certain markets.
    How Supplied:
    Testosterone implant pellets are available in select human
    drug markets. Composition and dosage may vary by country
    or manufacturer, but generally contain approximately 98.5%
    pure testosterone (along with some inert binders) in a small
    cylindrical pressed pellet.
    Structural Characteristics:
    Sterile testosterone pellets for implantation contain (free)
    testosterone in a pressed pellet. The pellets are implanted
    subcutaneously with a minor surgical procedure, and slowly
    dissolve over time, releasing testosterone into the blood.
    Testosterone pellets are designed to provide testosterone for
    approximately 4-6 months following implantation.
    Side Effects (Estrogenic):
    Testosterone is readily aromatized in the body to estradiol
    (estrogen). The aromatase (estrogen synthetase) enzyme is
    responsible for this metabolism of testosterone. Elevated
    estrogen levels can cause side effects such as increased
    water retention, body fat gain, and gynecomastia.
    Testosterone is considered a moderately estrogenic steroid.
    Exceeding therapeutic doses will increase the likelihood of
    estrogenic side effects. In such cases, an anti-estrogen such
    as clomiphene citrate or tamoxifen citrate is commonly
    applied to prevent estrogenic side effects. One may
    alternately use an aromatase inhibitor like Arimidex®
    (anastrozole), which more efficiently controls estrogen by
    preventing its synthesis. Aromatase inhibitors can be quite
    expensive in comparison to anti-estrogens, however, and
    may also have negative effects on blood lipids.
    Side Effects (Androgenic):
    Testosterone is the primary male androgen, responsible for
    maintaining secondary male sexual characteristics.
    Exceeding normal therapeutic doses is likely to produce
    androgenic side effects including oily skin, acne, and
    body/facial hair growth. Men with a genetic predisposition
    for hair loss (androgenetic alopecia) may notice accelerated
    male pattern balding. Women are warned of the potential
    virilizing effects of anabolic/androgenic steroids, especially
    with a strong androgen such as testosterone. These may
    include deepening of the voice, menstrual irregularities,
    changes in skin texture, facial hair growth, and clitoral
    In androgen-responsive target tissues such as the skin, scalp,
    and prostate, the high relative androgenicity of testosterone is
    dependant on its reduction to dihydrotestosterone (DHT).
    The 5-alpha reductase enzyme is responsible for this
    metabolism of testosterone. The concurrent use of a 5-alpha
    reductase inhibitor such as finasteride or dutasteride will
    interfere with site-specific potentiation of testosterone
    action, lowering the tendency of testosterone drugs to
    produce androgenic side effects. It is important to remember
    that anabolic and androgenic effects are both mediated via
    the cytosolic androgen receptor. Complete separation of
    testosterone’s anabolic and androgenic properties is not
    possible, even with total 5-alpha reductase inhibition.
    Side Effects (Hepatotoxicity):
    Testosterone does not have hepatotoxic effects; liver toxicity
    is unlikely. One study examined the potential for
    hepatotoxicity with high doses of testosterone by
    administering 400 mg of the hormone per day (2,800 mg per
    week) to a group of male subjects. The steroid was taken
    orally so that higher peak concentrations would be reached in
    hepatic tissues compared to intramuscular injections. The
    hormone was given daily for 20 days, and produced no
    significant changes in liver enzyme values including serum
    albumin, bilirubin, alanine-amino-transferase, and alkaline
    Side Effects (Cardiovascular):
    Anabolic/androgenic steroids can have deleterious effects on
    serum cholesterol. This includes a tendency to reduce HDL
    (good) cholesterol values and increase LDL (bad)
    cholesterol values, which may shift the HDL to LDL balance
    in a direction that favors greater risk of arteriosclerosis. The
    relative impact of an anabolic/androgenic steroid on serum
    lipids is dependant on the dose, route of administration (oral
    vs. injectable), type of steroid (aromatizable or nonaromatizable),
    and level of resistance to hepatic metabolism.
    Anabolic/androgenic steroids may also adversely affect
    blood pressure and triglycerides, reduce endothelial
    relaxation, and support left ventricular hypertrophy, all
    potentially increasing the risk of cardiovascular disease and
    myocardial infarction. Therapeutic doses of testosterone
    used to correct insufficient androgen production in otherwise
    healthy aging men are unlikely to increase atherogenic risk,
    and may actually reduce the risk of cardiovascular
    To help reduce cardiovascular strain it is advised to
    maintain an active cardiovascular exercise program and
    minimize the intake of saturated fats, cholesterol, and simple
    carbohydrates at all times during active AAS administration.
    Supplementing with fish oils (4 grams per day) and a natural
    cholesterol/antioxidant formula such as Lipid Stabil or a
    product with comparable ingredients is also recommended.
    Side Effects (Testosterone Suppression):
    All anabolic/androgenic steroids when taken in doses
    sufficient to promote muscle gain are expected to suppress
    endogenous testosterone production. Testosterone is the
    primary male androgen, and offers strong negative feedback
    on endogenous testosterone production. Testosterone-based
    drugs will, likewise, have a strong effect on the hypothalamic
    regulation of natural steroid hormones. Without the
    intervention of testosterone-stimulating substances,
    testosterone levels should return to normal within 1-4 months
    of the drug leaving the body. Note that prolonged
    hypogonadotrophic hypogonadism can develop secondary to
    steroid abuse, necessitating medical intervention.
    Administration (General):
    Sterile testosterone pellets are implanted subdermally in the
    lower abdominal wall. Prior to insertion, the skin is cleaned
    with alcohol and draped with a 2% xylocaine solution. A 2-
    cm incision is made through anaesthetized skin, and the
    pellets administered with the aid of a cannula. The incision
    site is covered with a sterile Band-Aid and a waterproof
    dressing for 1 week, and should not require stitching.
    Administration (Men):
    To treat androgen insufficiency, the prescribing guidelines
    for Testopel recommend implanting a row of 4-6 pellets
    (300-450 mg of testosterone) once every 4-6 months. For
    physique- or performance-enhancing purposes, higher doses
    would be necessary to achieve supraphysiological levels of
    testosterone. This would be in the range of 12-18 pellets per
    application, which is not highly practical given the higher
    volume and surgical requirements for implantation.
    Administration (Women):
    Testopel is not FDA-approved for use in women.
    Testosterone implant pellets are not recommended for
    women for physique- or performance-enhancing purposes
    due to their strong androgenic nature, tendency to produce
    virilizing side effects, and very slow-acting characteristics.
    Due to the relative impracticality of general private use,
    Testopel is not commonly traded on the black market

    By WL
    Thanks Presser thanked for this post
    Likes Presser, teeg liked this post

  2. #2
    MuscleChemistry Guru Board Certified MD
    freakinthegym's Avatar
    Join Date
    Jan 2008
    in the south
    Rep Power


    yeah not something i'l ever do. but nice post bro
    Likes akn liked this post
    All information discussed on these forums is purely for entertainment purposes

  3. #3
    Presser's Avatar
    Join Date
    May 2002
    Rep Power


    I would do it if the pellets were stronger in strength/dosage! Fuck yeah I would do it, hell i was gonna use a Fina Pellet gun once upon a time and shoot myself with finaplix pellets like they do to cattle lol, ok , i never really was going to do that, but i really would take an implant if i knew it was strong and evenly dosed!

    Fuck yeah I would do it!
    Likes akn, freakinthegym liked this post
    Author: Ben Presser
    Ph.D. P.E.D. Kinesiology
    Intramuscular Injection Certified

    MuscleChemistry Store

  4. #4
    Musclechemistry Member Board Certified CPH
    akn's Avatar
    Join Date
    Aug 2013
    here n there
    Rep Power


    Fina pallet that's insane bro lol

  5. #5
    MuscleChemistry Guru Board Certified MD
    freakinthegym's Avatar
    Join Date
    Jan 2008
    in the south
    Rep Power


    i have a freind that did implant, he hated it, now only oil,plus he has a bunch or 1 inch lines on his ass,lol
    Last edited by freakinthegym; 06-16-2014 at 04:50 PM.
    All information discussed on these forums is purely for entertainment purposes

Similar Threads

  1. Hrt/trt hormone replacement therapy. Testosterone Therapy
    By RagingWhoreMoan in forum Testosterone Replacement Therapy
    Replies: 1
    Last Post: 02-09-2019, 05:35 PM
  2. Hormone Replacement Therapy or Testosterone Replacement Therapy
    By big in vegas in forum MuscleChemistry Discussion
    Replies: 17
    Last Post: 04-08-2014, 05:27 PM
  3. Replies: 3
    Last Post: 10-22-2013, 01:08 AM
  4. Testosterone Replacement Therapy...
    By big in vegas in forum MuscleChemistry Discussion
    Replies: 24
    Last Post: 07-04-2013, 01:19 PM
  5. Testopel. Testosterone Hormone Replacement Pellets. Anti-Aging Medicine
    By gandhisays in forum Bodybuilding Steroid & Training Articles
    Replies: 0
    Last Post: 01-17-2013, 08:01 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts

Log in

Log in