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Thread: Anabolic Steroid Use and Elevated Liver Enzyme Levels

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    MuscleChemistry Registered Member MdTNT's Avatar
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    Post Anabolic Steroid Use and Elevated Liver Enzyme Levels



    IGF-1 Sale!
    England posted this on another site and i thought every one might get a good bit of info out of it....:

    Fried Liver

    by Jerry Brainium

    Your liver is your life. That sounds like a grandiose statement, but it’s true. The human liver is located behind the lower ribs, right below the diaphragm on the right side of the abdomen. It averages slightly more than three pounds in weight and is six inches thick. Without a functioning liver, you’d die a miserable death. Common food elements like protein would put you into a coma, since the by-products of protein metabolism, such as ammonia, would increase in the blood. In fact, many common food elements and drugs would prove fatal if you didn’t have this organ around to render them innocuous.

    The liver is a potent chemical-processing plant. It quietly performs more than 500 vital functions, including the following:

    •Manufactures bile, which is needed for complete fat absorption.

    •Converts protein, carbohydrate and fat into other elements.

    •Metabolizes drugs, including alcohol.

    •Cleanses the blood of toxins.

    •Produces blood-clotting factors, without which a minor cut could prove fatal.

    •Stores nutrients—such as fat-soluble vitamins A,D, E, and K; vitamin B12 and carbohydrate—as glycogen.

    •Maintains blood glucose levels by way of liver glycogen breakdown and release into the blood as glucose.

    •Synthesizes cholesterol and protein carriers for cholesterol in the blood.

    •Produces immune factors that protect against disease.

    That’s just a partial list. Obviously, you want to maintain proper liver function for maximum health. Many things are known to harm the liver, including excessive alcohol intake and drug use. From an athletic standpoint, certain types of anabolic steroids are frequently mentioned as having bad effects on liver function. They’re usually oral drugs that are classified as 17-alpha ankylated drugs.

    The designation “17-alpha ankylated” refers to a change made on position 17 of the basic steroid structure. Scientists developed the testosterone derivatives after noticing that orally taken testosterone is degraded in the liver in a process called first-pass metabolism. Drug developers circumvented that formidable problem by making testosterone available in an injectable form, which bypasses initial first-pass liver metabolism, and by manipulating the basic steroid chemical structure, as is the case with oral 17-alpha ankylated anabolic steroids.

    While the structural change in oral anabolic steroids did result in a far slower rate of breakdown in the liver, it also led to an inordinate buildup of such drugs in the liver. Since the injectable versions of steroids don’t build up in the liver as much as oral versions, the injectables are considered less of a problem in terms of normal liver function.

    The oral drugs adversely affect the liver through several mechanisms. For example, they interfere with the function of certain liver enzymes. Anabolic steroids are known to increase the activity of some liver enzymes while downgrading that of others. One enzyme that’s increased with oral anabolic steroid use is hepatic triglyceride lipase, which degrades high-density lipoprotein (HDL), a beneficial cholesterol carrier in the blood. A lowered HDL level is considered a risk factor for cardiovascular disease. Athletes who use oral anabolic steroids nearly always show depressed HDL levels. The buildup of 17-alpha ankylated oral anabolic steroids in the liver leads to a type of toxic or chemical hepatitis. Hepatitis, by the way, is a general word for an inflammation of the liver and can be caused by various factors, such as drug use and viruses. Oral steroids cause liver inflammation by promoting an increase in the size of liver cells, which leads to a congestion of bile flow through ducts in the liver that empty into the gallbladder, where bile is stored.

    The interference with bile flow induced by the effects of anabolic steroids on liver cells is called cholestasis. It usually occurs only in people who use higher doses of oral steroids or who use such steroids for extended periods of time. Certain oral steroids are reputed to have more potent toxic effect in the liver and to promote the liver swelling that can lead to cholestasis. They include oxymetholone (Anadrol-50) and fluoxymesterone (Halotestin), although it may be that those drugs cause problems because they’re often used in higher doses than other oral steroids. Both drugs are 17-alpha ankylated, as are most oral steroids.

    According to existing medical research, most cases of serious liver ailments due to oral anabolic steroid use have involved hospitalized patients who were given oral steroids such as Anadrol-50 to combat rare blood anemias. Many stayed on oral steroids for three or more years. The consensus of medical reviews is that certain potentially adverse liver changes do occur with athletic use—with the extent of the changes again depending on the drugs used, the doses and the length of time—but the changes regress when the athletes stop using the steroids. The liver is known to have an amazing capacity for regeneration unless it’s irrevocably damaged, a scenario that rarely occurs with short-term steroid use.

    Physicians often warn about elevated liver enzyme levels due to oral anabolic steroid use. While that could indicate an inflammation of the liver, the problem is that some of the measured liver enzymes aren’t specific to the liver and exist in other tissues. For example, two enzymes found in liver, ALT and AST, also exist in muscle. Any type of injury to muscle—including the kind that occurs with intense weight training—causes an elevation of those enzymes in the blood. A physician who’s not looking at the big picture—or measuring levels of other liver and muscle enzymes—may wrongly conclude that such liver enzyme increases are indicative of liver problems.1 Measuring enzymes such as creatine kinase and GGT would provide a more definitive picture of existing liver function, as would liver imaging tests.

    One visible early sign of liver inflammation due to oral steroid use is jaundice, which is characterized by a retention of bile in the body, leading to a yellow discoloration in the skin and whites of the eyes. Anyone using oral anabolic steroids should stop using them immediately if such symptoms occur. If you ignore the symptoms, you’re at risk for a more serious liver complication.

    Peliosis hepatis, as it’s called, consists of blood-filled cysts in the liver. It’s thought to be due to cholestasis; that is, the elevated pressure in liver tissue brought about by lack of proper bile flow in the liver leads to a breakdown of liver cells followed by the appearance of the cysts. The blood-filled cysts can rupture, leading to death. Most cases of peliosis have occurred in hospitalized patients on long-term steroid therapy, although the occurrence of peliosis isn’t dependent on dosage.

    One published instance of peliosis involved a 27-year-old bodybuilder who was using a steroid stack consisting of oxandrolone (Anavar), methandrostenolone (Dianabol), nandrolone (Durabolin) and testosterone for five weeks.2 What he took before that time wasn’t disclosed in the published report. The interesting aspect is that the drug stack he used isn’t considered highly toxic to the liver. The bodybuilder may have used more toxic oral steroids over a longer period, however, or he may have taken a drug such as Nolvadex, an estrogen blocker that few bodybuilders know can also cause peliosis if used in too high a dose for too long.

    The other serious liver disease often linked to oral anabolic steroid use is liver cancer. Reviews of liver cancer in various medical journals indicate that it’s of a more benign nature than other cancers. Simply put, the liver tumors that develop with steroid use usually regress if the person stops using the drugs. That’s not always the case, however.
    What you can not achieve is only what you are not willing to try for.

    Support cancer research...it could save your life!!!

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    Guru jaywooly's Avatar
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    I must be a better host to my liver.

    Good read, thanks.
    As always, these posts are for entertainment purposes only. Not to be taken as medical advice, or even serious for that matter.

    "Aint nothin' left to do but to do it."

    "Procrastination is like masturbation, you're only fucking yourself."

    "Far better people have done worse things."

    "After 2 dozen Krispy Kreme's I decided to dedicate my life to never doing that again."

    Proud member of CMF. Ride or die you beezy!

  3. #3
    saudades
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    Great read, MdTNT.

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    MuscleChemistry Guru modizzle's Avatar
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    Good read MdTNT.....definitely need to take care of this great organ...
    “Failure is simply the opportunity to begin again, this time more intelligently." --Henry Ford

    Ability is what you're capable of doing.

    Motivation determines what you do.

    Attitude determines how well you do it.


    "All info, advice, given out by me are merely for entertainment purposes" So don't Ask/PM me for Source. I will have you Banned for Life....

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    Yep, buy your Synthergine and feel good knowing that your liver has the best protection possible.

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    MuscleChemistry Registered Member MdTNT's Avatar
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    ....perfect time for that plug BigA...LOL.
    What you can not achieve is only what you are not willing to try for.

    Support cancer research...it could save your life!!!

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    Of course.
    It's helped by the fact that it's impossible to knock Synthergine.

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    MuscleChemistry Registered Member irishpride's Avatar
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    i too once had a liver..i miss him..
    I am the irishman your mother warned you about.....

    I dont have a girlfreind but i know a girl who would get really mad at me if she heard me say that...

    Disclaimer - My comments in no way promote the use of androgenic/anabolic steroids and/or any prescription drug without a physician's prescription. All my comments, questions and referrals are striclty for entertainment purposes only!

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    MuscleChemistry Guru Glen Whitestone's Avatar
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    Milk thistle? Has anyone heard of it? Can it really add some protection? Feed me some thoughts here!

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    MuscleChemistry Guru Cannons's Avatar
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    Good article!
    Cannons

    "If you don't live for something, you'll die for nothing! Live for this!" HATEBREED

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    Guru jaywooly's Avatar
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    Yes milk thistle is readily available in any vitamin store. It's too cheap not to use.
    As always, these posts are for entertainment purposes only. Not to be taken as medical advice, or even serious for that matter.

    "Aint nothin' left to do but to do it."

    "Procrastination is like masturbation, you're only fucking yourself."

    "Far better people have done worse things."

    "After 2 dozen Krispy Kreme's I decided to dedicate my life to never doing that again."

    Proud member of CMF. Ride or die you beezy!

  12. #12
    MuscleChemistry Guru modizzle's Avatar
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    Milk thistle is good for your liver....gotta have it in your routine..
    “Failure is simply the opportunity to begin again, this time more intelligently." --Henry Ford

    Ability is what you're capable of doing.

    Motivation determines what you do.

    Attitude determines how well you do it.


    "All info, advice, given out by me are merely for entertainment purposes" So don't Ask/PM me for Source. I will have you Banned for Life....

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    MuscleChemistry Registered Member MdTNT's Avatar
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    Big A's really on the money with synthergine though...
    What you can not achieve is only what you are not willing to try for.

    Support cancer research...it could save your life!!!

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    IFBB PRO Big A's Avatar
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    Milk Thistle's research is iffy at best. Much better, proven compounds out there to use.

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    Member saturn1's Avatar
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    Synthergine bump!

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